SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4knt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.24A 1oe1A-4kntA:
31.4		 1oe1A-4kntA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 ASP A  86
HIS A  88
HIS A 122
 CU  A 407 ( 4.1A)
CU  A 407 (-3.2A)
CU  A 407 (-3.2A)
 0.22A 1oe1A-4kntA:
31.4		 1oe1A-4kntA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 5 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.24A 1oe2A-4kntA:
31.5		 1oe2A-4kntA:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.24A 1oe3A-4kntA:
31.2		 1oe3A-4kntA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 ASP A  86
HIS A  88
HIS A 122
 CU  A 407 ( 4.1A)
CU  A 407 (-3.2A)
CU  A 407 (-3.2A)
 0.23A 1oe3A-4kntA:
31.2		 1oe3A-4kntA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 VAL A 289
ALA A 273
HIS A 227
 None
 0.76A 1q23C-4kntA:
undetectable		 1q23C-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 LEU A 226
PHE A 184
VAL A 289
ALA A 273
HIS A 227
 None
 1.21A 1q23H-4kntA:
undetectable
1q23I-4kntA:
undetectable		 1q23H-4kntA:
21.50
1q23I-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 VAL A 289
ALA A 273
HIS A 227
 None
 0.76A 1q23G-4kntA:
undetectable		 1q23G-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 VAL A 289
ALA A 273
HIS A 227
 None
 0.71A 1q23L-4kntA:
undetectable		 1q23L-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 GLY A 257
ASP A  86
GLY A 138
ILE A 160
ALA A 133
 None
CU  A 407 ( 4.1A)
None
None
None
 1.04A 1sguB-4kntA:
undetectable		 1sguB-4kntA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.73A 2fqdA-4kntA:
22.0		 2fqdA-4kntA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.71A 2fqeA-4kntA:
22.1		 2fqeA-4kntA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.71A 2fqfA-4kntA:
22.1		 2fqfA-4kntA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.72A 2fqgA-4kntA:
22.1		 2fqgA-4kntA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 7 TYR A  47
GLU A 163
TYR A 137
GLY A 219
 None
 1.25A 2ha4B-4kntA:
undetectable		 2ha4B-4kntA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 ARG A 134
GLU A  35
GLN A 130
 None
 1.02A 2p16A-4kntA:
undetectable		 2p16A-4kntA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.29A 2xxgA-4kntA:
31.5		 2xxgA-4kntA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 ASP A  86
HIS A  88
HIS A 122
 CU  A 407 ( 4.1A)
CU  A 407 (-3.2A)
CU  A 407 (-3.2A)
 0.19A 2xxgA-4kntA:
31.5		 2xxgA-4kntA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 5 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.27A 2xxgC-4kntA:
31.5		 2xxgC-4kntA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		3 / 3 ASP A  86
HIS A  88
HIS A 122
 CU  A 407 ( 4.1A)
CU  A 407 (-3.2A)
CU  A 407 (-3.2A)
 0.16A 2xxgC-4kntA:
31.5		 2xxgC-4kntA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 ASP A 263
TYR A 214
ILE A 308
ASN A 185
LEU A 226
 None
None
GOL  A 405 ( 4.6A)
None
None
 1.31A 4a84A-4kntA:
undetectable		 4a84A-4kntA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.71A 4ef3A-4kntA:
22.0		 4ef3A-4kntA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 7 PHE A  98
PHE A  87
TYR A 121
HIS A 122
 None
None
None
CU  A 407 (-3.2A)
 1.35A 4uciB-4kntA:
undetectable		 4uciB-4kntA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		4 / 8 PHE A 120
GLY A 257
ALA A 256
GLY A 219
 CU  A 407 ( 4.9A)
None
None
None
 0.68A 4zjzA-4kntA:
undetectable		 4zjzA-4kntA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 ARG A 309
LEU A 307
VAL A 183
TYR A  47
GLY A 135
 None
 1.13A 5i8fA-4kntA:
undetectable		 5i8fA-4kntA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 ARG A 309
VAL A 216
VAL A 183
TYR A  47
GLY A 135
 None
 1.35A 5i8fA-4kntA:
undetectable		 5i8fA-4kntA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 12 PHE A 120
ASN A 185
VAL A 158
VAL A  60
GLY A  58
 CU  A 407 ( 4.9A)
None
None
None
None
 0.94A 5x24A-4kntA:
undetectable		 5x24A-4kntA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4knt MULTICOPPER OXIDASE
TYPE 1
(Nitrosomonas
europaea) 		5 / 10 VAL A 118
GLY A 117
ASP A 258
ALA A 259
ASN A 244
 None
 1.06A 5x6yB-4kntA:
undetectable		 5x6yB-4kntA:
17.16