SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4knw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A 178
LEU A 179
GLN A 182
TYR A 174
PHE A  12
 None
 1.27A 3gwuA-4knwA:
undetectable		 3gwuA-4knwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 11 TYR A  41
LEU A  37
ILE A  50
THR A  75
ALA A  81
 None
 1.13A 3mdtB-4knwA:
undetectable		 3mdtB-4knwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 109
ARG A  28
GLU A  32
 None
 1.05A 3qf1A-4knwA:
undetectable		 3qf1A-4knwA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 12 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.05A 4x1iD-4knwA:
3.9		 4x1iD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 12 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.02A 4x1kD-4knwA:
3.8		 4x1kD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 12 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.00A 4x1yD-4knwA:
3.9		 4x1yD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A  22
CYH A 149
CYH A 147
LEU A  15
 None
None
None
VO4  A 301 (-4.2A)
 1.31A 5kxiA-4knwA:
undetectable
5kxiB-4knwA:
undetectable		 5kxiA-4knwA:
20.78
5kxiB-4knwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A  22
CYH A 149
CYH A 147
LEU A  15
 None
None
None
VO4  A 301 (-4.2A)
 1.30A 5kxiD-4knwA:
undetectable
5kxiE-4knwA:
undetectable		 5kxiD-4knwA:
20.78
5kxiE-4knwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		5 / 12 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 0.90A 5mioB-4knwA:
4.2		 5mioB-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A  18
CYH A 149
CYH A 147
LEU A 131
 None
 1.47A 6cnjD-4knwA:
undetectable
6cnjE-4knwA:
undetectable		 6cnjD-4knwA:
15.08
6cnjE-4knwA:
14.40