SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ko2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		4 / 5 ARG S 146
ALA S 128
ASP S 147
GLY S 130
 None
 1.11A 1e7bA-4ko2S:
0.3		 1e7bA-4ko2S:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 9 GLY S 266
PRO S 162
GLY S 163
GLY S 131
GLY S 130
 SF4  S 302 ( 4.5A)
None
None
None
None
 0.99A 1mxdA-4ko2S:
undetectable		 1mxdA-4ko2S:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 11 GLY S 266
PRO S 162
GLY S 163
GLY S 131
GLY S 130
 SF4  S 302 ( 4.5A)
None
None
None
None
 1.02A 1mxgA-4ko2S:
undetectable		 1mxgA-4ko2S:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 12 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.19A 2g70A-4ko2S:
undetectable		 2g70A-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 12 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.19A 2g70B-4ko2S:
undetectable		 2g70B-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 12 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.20A 2g72A-4ko2S:
undetectable		 2g72A-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 12 ILE S  36
LEU S  37
VAL S 123
VAL S 161
PRO S 165
 None
None
None
None
SF4  S 303 (-4.0A)
 1.11A 2ygpA-4ko2S:
undetectable		 2ygpA-4ko2S:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 9 LEU S 175
ALA S 119
VAL S 182
GLY S  70
PRO S   9
 None
 1.29A 3spkA-4ko2S:
undetectable		 3spkA-4ko2S:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 12 VAL S 121
ILE S  41
LEU S  43
PHE S  45
VAL S  49
 None
 1.10A 3w68B-4ko2S:
undetectable		 3w68B-4ko2S:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 9 GLU S 221
GLY S 230
PRO S 240
GLU S 283
GLY S 236
 None
None
SF4  S 301 ( 4.5A)
None
None
 1.10A 4fimA-4ko2S:
undetectable		 4fimA-4ko2S:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 9 MET S  50
SER S  52
ALA S  59
LEU S  58
PHE S 149
 None
 1.44A 4y28A-4ko2S:
undetectable
4y28J-4ko2S:
undetectable		 4y28A-4ko2S:
17.68
4y28J-4ko2S:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 9 SER S  52
ALA S  59
LEU S  58
GLY S  54
PHE S 149
 None
 1.31A 4y28A-4ko2S:
undetectable
4y28J-4ko2S:
undetectable		 4y28A-4ko2S:
17.68
4y28J-4ko2S:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		3 / 3 ARG S 198
ASP S 194
TYR S 243
 None
 0.90A 4yo9B-4ko2S:
undetectable		 4yo9B-4ko2S:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		4 / 6 GLY S  20
THR S  19
VAL S  23
HIS S  46
 SF4  S 303 ( 3.8A)
None
None
None
 1.06A 5ewuA-4ko2S:
undetectable		 5ewuA-4ko2S:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		4 / 8 HIS S  46
GLN S  14
LEU S  43
MET S 171
 None
 1.14A 5hs6A-4ko2S:
3.3		 5hs6A-4ko2S:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		4 / 6 THR S 242
GLY S 266
GLU S 269
ILE S 132
 SF4  S 302 (-4.4A)
SF4  S 302 ( 4.5A)
None
None
 0.89A 5kmfA-4ko2S:
undetectable
5kmfC-4ko2S:
undetectable		 5kmfA-4ko2S:
22.36
5kmfC-4ko2S:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 10 MET S  50
SER S  52
ALA S  59
LEU S  58
PHE S 149
 None
 1.43A 5zjiA-4ko2S:
undetectable
5zjiJ-4ko2S:
undetectable		 5zjiA-4ko2S:
12.95
5zjiJ-4ko2S:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT
(Desulfomicrobium
baculatum) 		5 / 10 ARG S 146
VAL S 145
LEU S 109
GLY S 130
VAL S  76
 None
 1.22A 6eu9B-4ko2S:
undetectable		 6eu9B-4ko2S:
15.05