SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A29_A_TFPA154_1 (CALMODULIN)	4kop	SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL (Arabidopsis thaliana)	5 / 10	GLU A 133 LEU A 167 MET A 94 LEU A 115 GLU A 119	None	1.40A	1a29A-4kopA: undetectable	1a29A-4kopA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LIN_A_TFPA154_1 (CALMODULIN)	4kop	SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL (Arabidopsis thaliana)	4 / 7	LEU A 167 MET A 94 LEU A 115 GLU A 119	None	0.88A	1linA-4kopA: undetectable	1linA-4kopA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRK_A_TFPA204_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4kop	SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL (Arabidopsis thaliana)	5 / 9	LEU A 115 PHE A 189 MET A 126 SER A 125 LEU A 152	None	1.36A	1wrkA-4kopA: undetectable 1wrkB-4kopA: undetectable	1wrkA-4kopA: 21.47 1wrkB-4kopA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTB_A_SAMA501_0 (HYDG PROTEIN)	4kop	SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL (Arabidopsis thaliana)	5 / 12	TYR A 58 VAL A 154 PHE A 96 ALA A 195 PHE A 196	None	1.39A	4rtbA-4kopA: undetectable	4rtbA-4kopA: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXC_A_ZITA306_1 (PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	4kop	SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL (Arabidopsis thaliana)	4 / 7	THR A 95 PHE A 113 LEU A 115 SER A 132	None MPO A 301 (-4.2A) None None	1.17A	5uxcA-4kopA: undetectable	5uxcA-4kopA: 19.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A29_A_TFPA154_1","CALMODULIN","4kop","SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL","Arabidopsis thaliana",5,"GLU A 133;LEU A 167;MET A  94;LEU A 115;GLU A 119","None","1.40A","1a29A-4kopA:undetectable","1a29A-4kopA:24.57"],["1LIN_A_TFPA154_1","CALMODULIN","4kop","SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL","Arabidopsis thaliana",4,"LEU A 167;MET A  94;LEU A 115;GLU A 119","None","0.88A","1linA-4kopA:undetectable","1linA-4kopA:24.57"],["1WRK_A_TFPA204_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4kop","SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL","Arabidopsis thaliana",5,"LEU A 115;PHE A 189;MET A 126;SER A 125;LEU A 152","None","1.36A","1wrkA-4kopA:undetectable;1wrkB-4kopA:undetectable","1wrkA-4kopA:21.47;1wrkB-4kopA:21.47"],["4RTB_A_SAMA501_0","HYDG PROTEIN","4kop","SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL","Arabidopsis thaliana",5,"TYR A  58;VAL A 154;PHE A  96;ALA A 195;PHE A 196","None","1.39A","4rtbA-4kopA:undetectable","4rtbA-4kopA:15.24"],["5UXC_A_ZITA306_1","PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE","4kop","SINGLE-STRANDED DNA-BINDING PROTEIN WHY2, MITOCHONDRIAL","Arabidopsis thaliana",4,"THR A  95;PHE A 113;LEU A 115;SER A 132","None;MPO A 301 (-4.2A);None;None","1.17A","5uxcA-4kopA:undetectable","5uxcA-4kopA:19.33"]]