SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A 306
ALA A 333
ASP A 309
GLY A 300
 None
 0.80A 1e7bA-4kp2A:
undetectable		 1e7bA-4kp2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A 306
ALA A 333
ASP A 309
GLY A 300
 None
 0.72A 1e7cA-4kp2A:
undetectable		 1e7cA-4kp2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 380
LEU A 373
HIS A 278
LEU A 173
 None
 0.86A 1errA-4kp2A:
undetectable		 1errA-4kp2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A 249
THR A 251
LEU A   3
ALA A 223
 None
 1.43A 2e1qD-4kp2A:
undetectable		 2e1qD-4kp2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 TRP A  51
GLU A 146
ALA A  29
ALA A 114
 None
 1.08A 2ejfA-4kp2A:
undetectable		 2ejfA-4kp2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  15
GLU A   5
VAL A  24
ASP A  20
ILE A  22
 None
 1.20A 3jayA-4kp2A:
undetectable		 3jayA-4kp2A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A 152
GLY A 183
ILE A 212
CYH A 121
PHE A 129
 None
 1.35A 3ko0H-4kp2A:
undetectable
3ko0I-4kp2A:
0.0		 3ko0H-4kp2A:
12.53
3ko0I-4kp2A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 294
ILE A 415
VAL A 297
ILE A 405
 None
 0.84A 3p4wC-4kp2A:
undetectable		 3p4wC-4kp2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 184
GLY A 219
ALA A 211
VAL A 175
VAL A 172
 None
 1.03A 3rukB-4kp2A:
undetectable		 3rukB-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 132
ASP A 117
GLY A 116
HIS A  62
 None
 0.87A 4c5nA-4kp2A:
undetectable		 4c5nA-4kp2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 157
ILE A 155
GLY A 216
ILE A 212
VAL A 172
 None
 0.94A 4dqfA-4kp2A:
undetectable		 4dqfA-4kp2A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 217
THR A 131
ILE A 141
 None
 0.49A 4e0fB-4kp2A:
undetectable		 4e0fB-4kp2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 220
THR A 206
ILE A 179
VAL A 157
ILE A 159
 None
 1.10A 4eb6B-4kp2A:
undetectable
4eb6C-4kp2A:
undetectable		 4eb6B-4kp2A:
20.48
4eb6C-4kp2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 301
GLY A 305
THR A 122
ASP A 309
 None
 0.95A 4eohA-4kp2A:
undetectable		 4eohA-4kp2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ASN A  52
ARG A  84
ASP A  48
GLY A  86
ASP A  54
 None
 1.35A 4evyA-4kp2A:
undetectable
4evyB-4kp2A:
undetectable		 4evyA-4kp2A:
20.22
4evyB-4kp2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 184
GLY A 219
ALA A 211
VAL A 175
VAL A 172
 None
 0.98A 4nkvA-4kp2A:
undetectable		 4nkvA-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 184
GLY A 219
ALA A 211
VAL A 175
VAL A 172
 None
 0.98A 4nkvB-4kp2A:
undetectable		 4nkvB-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 184
GLY A 219
ALA A 211
VAL A 175
VAL A 172
 None
 0.98A 4nkvC-4kp2A:
undetectable		 4nkvC-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 410
ILE A 357
GLY A 354
ALA A 353
VAL A 330
 None
 1.09A 4nkvC-4kp2A:
undetectable		 4nkvC-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 184
GLY A 219
ALA A 211
VAL A 175
VAL A 172
 None
 0.99A 4nkvD-4kp2A:
undetectable		 4nkvD-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 410
ILE A 357
GLY A 354
ALA A 353
VAL A 330
 None
 1.10A 4nkvD-4kp2A:
undetectable		 4nkvD-4kp2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 221
ASP A 224
ARG A 156
THR A 227
 None
 1.17A 4nx6A-4kp2A:
undetectable		 4nx6A-4kp2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 221
ASP A 224
ARG A 156
THR A 227
 None
 1.18A 4nx7A-4kp2A:
undetectable		 4nx7A-4kp2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A 407
VAL A 330
GLY A 300
THR A 382
 None
 1.14A 4ubeA-4kp2A:
undetectable		 4ubeA-4kp2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A 192
ASP A 158
ARG A 254
MET A 187
 None
 0.89A 5gwkA-4kp2A:
undetectable		 5gwkA-4kp2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  30
HIS A  99
GLY A 132
 None
 0.63A 5gwzB-4kp2A:
undetectable		 5gwzB-4kp2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 TRP A  51
PHE A 112
GLU A 146
THR A  35
 None
 1.38A 5hqaA-4kp2A:
undetectable		 5hqaA-4kp2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  32
ASP A  61
HIS A  62
 None
 0.77A 5n1tW-4kp2A:
undetectable		 5n1tW-4kp2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  30
ASP A  61
ARG A 385
 None
 0.87A 5z6jA-4kp2A:
undetectable		 5z6jA-4kp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  30
ASP A  61
ARG A 385
 None
 1.02A 5z6kA-4kp2A:
undetectable		 5z6kA-4kp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A   2
THR A 218
PHE A 129
ILE A  22
VAL A 151
 None
 1.09A 6hcoA-4kp2A:
undetectable
6hcoB-4kp2A:
undetectable		 6hcoA-4kp2A:
20.67
6hcoB-4kp2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4kp2 HOMOACONITASE LARGE
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 171
ILE A 265
GLU A 164
VAL A 195
ILE A 159
 None
 1.32A 6hloA-4kp2A:
2.4		 6hloA-4kp2A:
22.67