SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE
(Escherichia
coli;
Thermotoga
maritima) 		5 / 11 ARG A1317
ILE A1319
ASP A1373
GLY A1375
ILE A1399
 None
None
ANP  A1501 (-3.2A)
None
None
 0.94A 2fxdA-4kp4A:
undetectable		 2fxdA-4kp4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE
(Escherichia
coli;
Thermotoga
maritima) 		3 / 3 GLY A1326
TYR A1324
SER A1327
 None
 0.69A 2xatA-4kp4A:
undetectable		 2xatA-4kp4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE
(Escherichia
coli;
Thermotoga
maritima) 		4 / 6 ALA A1407
ILE A1408
HIS A 243
ASN A1343
 None
None
ANP  A1501 (-4.1A)
None
 0.77A 3nneG-4kp4A:
undetectable		 3nneG-4kp4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE
(Escherichia
coli;
Thermotoga
maritima) 		5 / 9 THR A1321
LEU A1323
LEU A1305
GLY A1306
VAL A1345
 None
 1.48A 4c9kA-4kp4A:
undetectable		 4c9kA-4kp4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE
(Escherichia
coli;
Thermotoga
maritima) 		5 / 10 ARG A1397
ALA A1396
GLY A1403
ARG A 246
SER A 242
 None
ANP  A1501 (-2.7A)
ANP  A1501 (-3.1A)
None
None
 1.42A 6clxB-4kp4A:
undetectable		 6clxB-4kp4A:
23.50