SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4kp9 PAPAIN
(Carica
papaya) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 BU1  A 301 (-3.1A)
BU1  A 301 (-3.2A)
None
None
None
None
YXZ  A 305 (-3.4A)
 1.16A 1stfE-4kp9A:
40.7
1stfI-4kp9A:
0.6		 1stfE-4kp9A:
99.53
1stfI-4kp9A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4kp9 PAPAIN
(Carica
papaya) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 BU1  A 301 (-3.1A)
BU1  A 301 (-3.2A)
None
TXY  A  67 ( 4.3A)
None
None
BU1  A 301 (-4.1A)
None
 0.23A 1stfE-4kp9A:
40.7
1stfI-4kp9A:
0.6		 1stfE-4kp9A:
99.53
1stfI-4kp9A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.04A 2v2gA-4kp9A:
undetectable
2v2gB-4kp9A:
undetectable		 2v2gA-4kp9A:
22.35
2v2gB-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.02A 2v2gA-4kp9A:
undetectable
2v2gB-4kp9A:
undetectable		 2v2gA-4kp9A:
22.35
2v2gB-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.04A 2v2gC-4kp9A:
undetectable
2v2gD-4kp9A:
undetectable		 2v2gC-4kp9A:
22.35
2v2gD-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.04A 2v2gC-4kp9A:
undetectable
2v2gD-4kp9A:
undetectable		 2v2gC-4kp9A:
22.35
2v2gD-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 8 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 0.99A 2v32A-4kp9A:
undetectable
2v32B-4kp9A:
undetectable		 2v32A-4kp9A:
22.35
2v32B-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.03A 2v41E-4kp9A:
undetectable
2v41F-4kp9A:
undetectable		 2v41E-4kp9A:
22.35
2v41F-4kp9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.08A 2v41E-4kp9A:
undetectable
2v41F-4kp9A:
undetectable		 2v41E-4kp9A:
22.35
2v41F-4kp9A:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 177
 BU1  A 301 (-3.1A)
BU1  A 301 (-3.2A)
BU1  A 301 (-4.1A)
ACT  A 303 ( 4.8A)
 0.59A 3ai8A-4kp9A:
26.9		 3ai8A-4kp9A:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4kp9 PAPAIN
(Carica
papaya) 		3 / 3 LEU A  74
ARG A  59
ARG A  58
 None
 0.83A 4yiaB-4kp9A:
undetectable		 4yiaB-4kp9A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 8 PRO A 209
ALA A  27
THR A  33
ALA A 105
 None
 1.00A 5x2tI-4kp9A:
undetectable
5x2tJ-4kp9A:
undetectable
5x2tK-4kp9A:
undetectable
5x2tL-4kp9A:
undetectable		 5x2tI-4kp9A:
19.72
5x2tJ-4kp9A:
20.00
5x2tK-4kp9A:
19.72
5x2tL-4kp9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 5 GLY A 201
THR A 204
SER A 131
SER A 206
 None
 1.03A 6jmjA-4kp9A:
undetectable		 6jmjA-4kp9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4kp9 PAPAIN
(Carica
papaya) 		4 / 6 GLY A 201
THR A 204
SER A 131
SER A 206
 None
 1.05A 6jogA-4kp9A:
undetectable		 6jogA-4kp9A:
20.28