SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 308
SER A 310
GLY A 315
PHE A 335
 None
 0.88A 1fapB-4kpgA:
undetectable		 1fapB-4kpgA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 1.03A 1hwiB-4kpgA:
undetectable		 1hwiB-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 0.95A 1hwkA-4kpgA:
undetectable		 1hwkA-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 0.92A 1hwkC-4kpgA:
undetectable		 1hwkC-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
SER A 118
ASP A 111
 None
 1.25A 1hwkC-4kpgA:
undetectable		 1hwkC-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 0.94A 1hwkD-4kpgA:
undetectable		 1hwkD-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
SER A 118
ASP A 111
 None
 1.26A 1hwkD-4kpgA:
undetectable		 1hwkD-4kpgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.71A 1mz9A-4kpgA:
undetectable		 1mz9A-4kpgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.67A 1mz9C-4kpgA:
undetectable		 1mz9C-4kpgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 384
TRP A 391
GLY A 372
ALA A 367
ALA A 380
 None
 1.03A 1nw5A-4kpgA:
undetectable		 1nw5A-4kpgA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 384
TRP A 391
GLY A 373
ALA A 367
ALA A 380
 None
 1.23A 1nw5A-4kpgA:
undetectable		 1nw5A-4kpgA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
THR A 366
ASP A 384
LEU A 346
LEU A 389
 None
 1.10A 1rjdA-4kpgA:
undetectable		 1rjdA-4kpgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
THR A 366
ASP A 384
LEU A 346
LEU A 389
 None
 1.08A 1rjdB-4kpgA:
2.2		 1rjdB-4kpgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
THR A 366
ASP A 384
LEU A 346
LEU A 389
 None
 1.08A 1rjdC-4kpgA:
undetectable		 1rjdC-4kpgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.96A 1rs7A-4kpgA:
undetectable		 1rs7A-4kpgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.93A 1rs7B-4kpgA:
undetectable		 1rs7B-4kpgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 2avvD-4kpgA:
undetectable		 2avvD-4kpgA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.88A 2avvE-4kpgA:
undetectable		 2avvE-4kpgA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 357
ILE A 360
VAL A 226
ALA A 225
ILE A 199
 None
 0.95A 2h42B-4kpgA:
undetectable		 2h42B-4kpgA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
ALA A 388
ALA A  77
LEU A 346
ILE A  74
 None
 1.03A 2h77A-4kpgA:
undetectable		 2h77A-4kpgA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.99A 2hs2B-4kpgA:
undetectable		 2hs2B-4kpgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.98A 2pymA-4kpgA:
undetectable		 2pymA-4kpgA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.96A 2pynA-4kpgA:
undetectable		 2pynA-4kpgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.94A 2q63B-4kpgA:
undetectable		 2q63B-4kpgA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 2q64A-4kpgA:
undetectable		 2q64A-4kpgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 MET A 294
VAL A 382
GLU A 306
 None
 0.81A 2x9gA-4kpgA:
3.5		 2x9gA-4kpgA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 302
SER A 295
GLY A 238
THR A 240
VAL A 235
 None
 1.21A 2zifA-4kpgA:
undetectable		 2zifA-4kpgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.97A 3d1xB-4kpgA:
undetectable		 3d1xB-4kpgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A  72
GLY A 132
ILE A 131
ALA A  68
ILE A  74
 None
 0.93A 3ekpB-4kpgA:
undetectable		 3ekpB-4kpgA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.89A 3el1A-4kpgA:
undetectable		 3el1A-4kpgA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
ALA A 388
ALA A  77
LEU A 346
ILE A  74
 None
 1.03A 3gwsX-4kpgA:
undetectable		 3gwsX-4kpgA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.95A 3k4vD-4kpgA:
undetectable		 3k4vD-4kpgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.04A 3keeA-4kpgA:
undetectable		 3keeA-4kpgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.04A 3keeD-4kpgA:
undetectable		 3keeD-4kpgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 336
GLY A 305
SER A 293
 None
 0.67A 3loqA-4kpgA:
undetectable		 3loqA-4kpgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A 280
LEU A 278
TYR A 339
VAL A 382
GLY A 379
 None
 1.19A 3ls4H-4kpgA:
undetectable		 3ls4H-4kpgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.94A 3ndtC-4kpgA:
undetectable		 3ndtC-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.96A 3ndtD-4kpgA:
undetectable		 3ndtD-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.88A 3nduA-4kpgA:
undetectable		 3nduA-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 3nduB-4kpgA:
undetectable		 3nduB-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 3nduC-4kpgA:
undetectable		 3nduC-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.92A 3nduD-4kpgA:
undetectable		 3nduD-4kpgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 181
GLU A 203
ALA A 178
ASP A 243
GLN A 176
 None
 1.19A 3nmuB-4kpgA:
undetectable
3nmuJ-4kpgA:
undetectable		 3nmuB-4kpgA:
22.94
3nmuJ-4kpgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.95A 3pwrA-4kpgA:
undetectable		 3pwrA-4kpgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.07A 3sueA-4kpgA:
undetectable		 3sueA-4kpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.07A 3sueB-4kpgA:
undetectable		 3sueB-4kpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.98A 3sufA-4kpgA:
undetectable		 3sufA-4kpgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.08A 3sufC-4kpgA:
undetectable		 3sufC-4kpgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.94A 3tkgA-4kpgA:
undetectable		 3tkgA-4kpgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.95A 3tkgB-4kpgA:
undetectable		 3tkgB-4kpgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.95A 4kcnA-4kpgA:
undetectable		 4kcnA-4kpgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  90
ALA A  89
GLY A 133
ASP A  92
THR A 127
 None
 1.23A 4mm8A-4kpgA:
undetectable		 4mm8A-4kpgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 339
ALA A 129
GLY A 133
GLY A 143
GLY A 312
 None
 1.02A 4obwB-4kpgA:
undetectable		 4obwB-4kpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 124
ASP A 121
ILE A 131
ASN A 200
GLY A 133
 None
 1.16A 4obwC-4kpgA:
undetectable		 4obwC-4kpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 233
VAL A 226
ALA A 225
VAL A  34
ALA A  31
 None
 1.22A 4oqrA-4kpgA:
undetectable		 4oqrA-4kpgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 119
SER A  98
GLY A 124
PHE A 141
GLY A 315
 None
 1.41A 4pevB-4kpgA:
4.8		 4pevB-4kpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 338
VAL A  95
GLY A 133
SER A 310
GLY A 312
 None
 1.26A 4xp4A-4kpgA:
0.4		 4xp4A-4kpgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.18A 5eypB-4kpgA:
3.0		 5eypB-4kpgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.47A 5igjA-4kpgA:
undetectable		 5igjA-4kpgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 299
SER A 295
TRP A 298
 None
 1.04A 5jwaA-4kpgA:
undetectable		 5jwaA-4kpgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 195
ALA A 231
GLY A 230
ALA A 225
ILE A 199
 None
 0.91A 5kb6B-4kpgA:
3.8		 5kb6B-4kpgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 SER A 118
ALA A 159
ASP A 121
SER A 157
 None
 1.11A 5l5fY-4kpgA:
undetectable
5l5fZ-4kpgA:
undetectable		 5l5fY-4kpgA:
20.72
5l5fZ-4kpgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.96A 5lf3K-4kpgA:
undetectable
5lf3L-4kpgA:
undetectable		 5lf3K-4kpgA:
22.11
5lf3L-4kpgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.97A 5lf3Y-4kpgA:
undetectable
5lf3Z-4kpgA:
undetectable		 5lf3Y-4kpgA:
22.11
5lf3Z-4kpgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.27A 5nm5B-4kpgA:
2.6		 5nm5B-4kpgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  56
VAL A 318
GLN A 316
 None
 0.67A 5qhaA-4kpgA:
undetectable		 5qhaA-4kpgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.05A 6c2mC-4kpgA:
undetectable		 6c2mC-4kpgA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 393
ALA A 365
GLY A 300
ASN A 361
ARG A 362
 None
 1.30A 6nm4B-4kpgA:
undetectable		 6nm4B-4kpgA:
16.79