SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		4 / 8 LEU A  19
ARG A  34
LEU A 130
SER A  75
 None
 1.09A 1hk3A-4kpkA:
undetectable		 1hk3A-4kpkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		5 / 12 LEU A  67
LEU A 130
LEU A 101
LEU A  53
THR A 115
 None
 1.21A 1zucB-4kpkA:
undetectable		 1zucB-4kpkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		4 / 5 ILE A 138
ASN A 197
ILE A 196
ASP A 195
 None
 1.08A 2h4jA-4kpkA:
undetectable		 2h4jA-4kpkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		3 / 3 LEU A  53
MET A 107
MET A 219
 None
 0.97A 2vavF-4kpkA:
2.6		 2vavF-4kpkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		5 / 12 GLY A  77
ARG A  34
MET A  49
LEU A 104
ILE A 159
 None
 1.17A 3h52A-4kpkA:
undetectable		 3h52A-4kpkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		5 / 12 GLY A 126
GLY A 129
VAL A 158
ALA A  78
SER A 134
 None
 1.15A 3mteA-4kpkA:
undetectable		 3mteA-4kpkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		4 / 8 SER A  47
ARG A  58
ILE A  50
GLU A  48
 None
 1.18A 4cx7C-4kpkA:
undetectable
4cx7D-4kpkA:
undetectable		 4cx7C-4kpkA:
19.63
4cx7D-4kpkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		4 / 8 LEU A 130
PHE A  41
MET A  49
LEU A 101
 None
 0.92A 5mzjA-4kpkA:
undetectable		 5mzjA-4kpkA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4kpk ENOYL-COA
HYDRATASE/ISOMERASE
(Shewanella
pealeana) 		3 / 3 GLU A 180
ARG A 174
TYR A 175
 None
 0.49A 5trqB-4kpkA:
undetectable		 5trqB-4kpkA:
24.50