SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.82A 1c6yB-4kpnA:
undetectable		 1c6yB-4kpnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		6 / 12 GLY A 199
ALA A 200
ILE A 138
ILE A 194
ILE A 166
ILE A 164
 None
 0.90A 1hshC-4kpnA:
undetectable		 1hshC-4kpnA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 9 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.94A 1hxwA-4kpnA:
undetectable		 1hxwA-4kpnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 10 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.93A 1muiA-4kpnA:
undetectable		 1muiA-4kpnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.90A 1ohrA-4kpnA:
undetectable		 1ohrA-4kpnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 7 LEU A 167
VAL A 205
GLY A 206
VAL A 317
 None
 0.80A 1p2yA-4kpnA:
undetectable		 1p2yA-4kpnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 LEU A 167
GLU A 182
GLY A 169
ILE A 209
LEU A 326
 None
 1.00A 1p91A-4kpnA:
2.7		 1p91A-4kpnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		3 / 3 VAL A 263
ALA A 260
HIS A 257
 None
 0.77A 1q23C-4kpnA:
undetectable		 1q23C-4kpnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		3 / 3 VAL A 263
ALA A 260
HIS A 257
 None
 0.76A 1q23L-4kpnA:
undetectable		 1q23L-4kpnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.86A 1sdvB-4kpnA:
undetectable		 1sdvB-4kpnA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 4 THR A 210
GLY A 142
ASP A  25
ALA A 183
 None
CA  A 400 ( 4.4A)
CA  A 400 (-2.9A)
None
 1.23A 1sg9A-4kpnA:
4.0		 1sg9A-4kpnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 4 THR A 261
GLY A 142
ASP A  25
ALA A 183
 None
CA  A 400 ( 4.4A)
CA  A 400 (-2.9A)
None
 1.27A 1sg9A-4kpnA:
4.0		 1sg9A-4kpnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A 199
ALA A 200
ILE A 138
ILE A 194
ILE A 164
 None
 0.92A 2b60A-4kpnA:
undetectable		 2b60A-4kpnA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.95A 2b60B-4kpnA:
undetectable		 2b60B-4kpnA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 7 LEU A 256
THR A 210
HIS A 211
GLY A 168
 None
 1.03A 2ddwB-4kpnA:
6.2		 2ddwB-4kpnA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 LEU A  48
VAL A  78
GLY A  81
THR A  61
ALA A  64
 None
 0.70A 2egvA-4kpnA:
4.4		 2egvA-4kpnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 LEU A  48
VAL A  78
GLY A  81
THR A  61
ALA A  64
 None
 0.70A 2egvB-4kpnA:
4.6		 2egvB-4kpnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 LEU A 144
ALA A 148
ILE A 164
ALA A 140
ASP A 188
 None
 1.24A 2ejtA-4kpnA:
2.8		 2ejtA-4kpnA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 ALA A 200
ILE A 202
VAL A 151
ALA A 150
LEU A  86
 None
 1.05A 2h42B-4kpnA:
undetectable		 2h42B-4kpnA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.79A 2hs2A-4kpnA:
undetectable		 2hs2A-4kpnA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.85A 2o4sA-4kpnA:
undetectable		 2o4sA-4kpnA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.86A 2r5pD-4kpnA:
undetectable		 2r5pD-4kpnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 10 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.95A 2r5qD-4kpnA:
undetectable		 2r5qD-4kpnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 9 ILE A 138
PHE A 157
ALA A 158
VAL A 161
 None
 0.70A 2vufA-4kpnA:
undetectable		 2vufA-4kpnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 280
CYH A 286
LEU A 289
THR A 290
ILE A 285
 None
 1.19A 3a35A-4kpnA:
undetectable		 3a35A-4kpnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 280
CYH A 286
LEU A 289
THR A 290
ILE A 285
 None
 1.18A 3a35B-4kpnA:
undetectable		 3a35B-4kpnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 280
CYH A 286
LEU A 289
THR A 290
ILE A 285
 None
 1.18A 3a3bA-4kpnA:
undetectable		 3a3bA-4kpnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.79A 3d1xA-4kpnA:
undetectable		 3d1xA-4kpnA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.88A 3ekxA-4kpnA:
undetectable		 3ekxA-4kpnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 10 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.97A 3ekyA-4kpnA:
undetectable		 3ekyA-4kpnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 5 ILE A 138
THR A 145
PHE A  82
PHE A 120
 None
 1.21A 3em0A-4kpnA:
undetectable		 3em0A-4kpnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 ILE A 202
MET A 262
VAL A  45
LEU A  48
THR A  49
 None
 1.36A 3em0B-4kpnA:
undetectable		 3em0B-4kpnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 HIS A  99
ALA A 183
GLY A 187
GLY A  53
VAL A 177
 None
 0.99A 3f8wC-4kpnA:
undetectable		 3f8wC-4kpnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 ALA A 314
LEU A 167
THR A 290
ILE A 185
LEU A 144
 None
 1.10A 3hj3A-4kpnA:
undetectable		 3hj3A-4kpnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		3 / 3 CYH A 198
PRO A 310
ASP A 201
 None
 0.96A 3hlwB-4kpnA:
undetectable		 3hlwB-4kpnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 4 PRO A 302
THR A 303
GLY A 276
THR A 275
 None
 1.02A 3ib1A-4kpnA:
1.1		 3ib1A-4kpnA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 8 GLY A  81
PHE A  82
ILE A 126
CYH A 153
 None
 0.86A 3ko0O-4kpnA:
undetectable
3ko0Q-4kpnA:
undetectable		 3ko0O-4kpnA:
13.57
3ko0Q-4kpnA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 7 LEU A 326
LEU A 256
THR A 210
VAL A 205
 None
 1.02A 3ozkB-4kpnA:
undetectable		 3ozkB-4kpnA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 8 PHE A  70
ALA A  31
PHE A  35
ALA A 237
THR A 107
 None
 1.25A 3t3sD-4kpnA:
undetectable		 3t3sD-4kpnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 7 TYR A 241
ASP A  29
HIS A 211
HIS A  99
 None
CA  A 400 ( 4.5A)
None
None
 1.25A 3zodA-4kpnA:
undetectable		 3zodA-4kpnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		3 / 3 ASP A  29
VAL A 263
ASN A 184
 CA  A 400 ( 4.5A)
None
CA  A 400 ( 4.2A)
 0.78A 4lmnA-4kpnA:
undetectable		 4lmnA-4kpnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A  98
TYR A 244
TYR A 241
VAL A  55
GLY A 103
 None
 1.14A 4mm6A-4kpnA:
undetectable		 4mm6A-4kpnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 5 ASN A  63
PRO A  26
GLY A 103
ASP A 188
 None
 0.92A 4n48B-4kpnA:
undetectable		 4n48B-4kpnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 1.01A 4njvB-4kpnA:
undetectable		 4njvB-4kpnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.99A 4njvC-4kpnA:
undetectable		 4njvC-4kpnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 LEU A  38
ALA A  71
LEU A  67
THR A  50
ALA A  37
 None
 0.90A 4o2bD-4kpnA:
6.2		 4o2bD-4kpnA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 6 ARG A  73
ALA A  71
ASP A  75
SER A  40
 None
 1.15A 4ot2A-4kpnA:
undetectable		 4ot2A-4kpnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 7 GLN A 127
THR A 119
ILE A 117
ASP A 118
 None
 0.98A 4pcuA-4kpnA:
undetectable		 4pcuA-4kpnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 ALA A  60
GLY A  27
ASP A  29
ILE A  51
ILE A  34
 None
None
CA  A 400 ( 4.5A)
None
None
 0.94A 4q5mA-4kpnA:
undetectable		 4q5mA-4kpnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 5 TYR A 241
HIS A 245
ASP A  30
ASP A  23
 None
None
CA  A 400 (-2.3A)
None
 1.40A 4qdjA-4kpnA:
2.7		 4qdjA-4kpnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 9 THR A 290
ALA A 192
ALA A 191
GLY A 169
GLY A 168
 None
 1.17A 4qwuY-4kpnA:
undetectable
4qwuZ-4kpnA:
undetectable		 4qwuY-4kpnA:
22.60
4qwuZ-4kpnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		3 / 3 THR A  49
THR A  50
PHE A  82
 None
 0.91A 5cxvA-4kpnA:
undetectable		 5cxvA-4kpnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.86A 5e5kB-4kpnA:
undetectable		 5e5kB-4kpnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 11 ILE A  34
ASP A  25
ALA A  64
LEU A  68
VAL A  78
 None
CA  A 400 (-2.9A)
None
None
None
 1.32A 5hw4B-4kpnA:
1.4		 5hw4B-4kpnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		4 / 6 GLY A 175
ASP A 258
ILE A 254
TYR A 244
 None
CA  A 400 (-2.8A)
None
None
 1.02A 5iwuA-4kpnA:
undetectable		 5iwuA-4kpnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.75A 5kqxA-4kpnA:
undetectable		 5kqxA-4kpnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
TYR A  52
ALA A 237
ASP A  30
ALA A  31
 None
None
None
CA  A 400 (-2.3A)
None
 1.07A 5kvaA-4kpnA:
4.0		 5kvaA-4kpnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
TYR A  52
ALA A 237
ASP A  30
ALA A  31
 None
None
None
CA  A 400 (-2.3A)
None
 1.07A 5kvaB-4kpnA:
4.0		 5kvaB-4kpnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 10 ILE A 194
PHE A 196
VAL A 151
ASP A  23
ILE A 164
 None
 1.21A 5lg3H-4kpnA:
undetectable		 5lg3H-4kpnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 PHE A 132
ILE A  46
ALA A 121
ILE A  21
PRO A  77
 None
 1.47A 5mlmA-4kpnA:
undetectable		 5mlmA-4kpnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 LEU A  38
ALA A  71
LEU A  67
THR A  50
ALA A  37
 None
 0.88A 5xiwB-4kpnA:
5.4		 5xiwB-4kpnA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 GLY A  27
ASP A  29
GLY A 142
ILE A  51
ILE A  34
 None
CA  A 400 ( 4.5A)
CA  A 400 ( 4.4A)
None
None
 0.89A 6dj1A-4kpnA:
undetectable		 6dj1A-4kpnA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 266
LEU A 234
LEU A 223
ALA A  37
LEU A 141
 None
 1.07A 6ew0B-4kpnA:
4.8		 6ew0B-4kpnA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 266
LEU A 234
LEU A 223
ALA A  37
LEU A 141
 None
 1.07A 6ew0D-4kpnA:
5.0		 6ew0D-4kpnA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 266
LEU A 234
LEU A 223
ALA A  37
LEU A 141
 None
 1.07A 6ew0H-4kpnA:
5.2		 6ew0H-4kpnA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1
(Physcomitrella
patens) 		5 / 12 VAL A 266
LEU A 234
LEU A 223
ALA A  37
LEU A 141
 None
 1.07A 6ew0I-4kpnA:
5.3		 6ew0I-4kpnA:
14.49