SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 ASN A 150
VAL A  67
GLY A  68
TRP A 153
LEU A 252
 None
None
None
SIA  A 801 (-3.6A)
None
 1.22A 1fkoA-4kpsA:
undetectable		 1fkoA-4kpsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 LEU A 106
LEU A 100
VAL A 178
GLY A 257
ARG A 118
 None
 1.48A 1y4lB-4kpsA:
undetectable		 1y4lB-4kpsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 106
LEU A 109
ARG A 114
TYR A 258
 None
 0.92A 2hc4A-4kpsA:
undetectable		 2hc4A-4kpsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 VAL A 186
GLY A 250
GLY A 249
ASN A 248
ILE A 182
 None
 1.45A 3owxA-4kpsA:
undetectable
3owxB-4kpsA:
undetectable		 3owxA-4kpsA:
22.70
3owxB-4kpsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 TYR A 195
TYR A 161
ALA A 253
ILE A 182
 None
 1.12A 4uymB-4kpsA:
undetectable		 4uymB-4kpsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 THR A 217
VAL A 188
PRO A 200
THR A 191
 None
 1.35A 5mthA-4kpsA:
undetectable
5mthH-4kpsA:
undetectable		 5mthA-4kpsA:
19.63
5mthH-4kpsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4kps HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 GLU A 120
ARG A 255
TYR A 256
 None
 0.63A 5trqB-4kpsA:
undetectable		 5trqB-4kpsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4kps HEMAGGLUTININ
HEMAGGLUTININ
(Influenza
A
virus;
Influenza
A
virus) 		5 / 10 LEU A  37
ASP A  36
ILE B  48
SER A  34
GLY A 320
 None
 1.17A 6dm0B-4kpsA:
undetectable
6dm0C-4kpsA:
undetectable		 6dm0B-4kpsA:
13.06
6dm0C-4kpsA:
13.06