SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 12 GLY A 166
LEU A 173
VAL A 137
ILE A 118
SER A 114
 None
 1.14A 1zq9A-4kptA:
undetectable		 1zq9A-4kptA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		4 / 7 ALA A 214
TYR A 211
TYR A  38
PHE A  76
 None
None
MES  A 301 (-3.8A)
MES  A 301 ( 3.7A)
 0.92A 2ajvH-4kptA:
undetectable
2ajvL-4kptA:
undetectable		 2ajvH-4kptA:
23.05
2ajvL-4kptA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 10 TYR A 111
ILE A 243
ILE A  53
GLY A  94
LEU A 231
 None
None
None
MES  A 301 (-4.6A)
None
 1.15A 3elzB-4kptA:
undetectable		 3elzB-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 10 TYR A 111
ILE A 243
ILE A  53
GLY A  94
TYR A  73
 None
None
None
MES  A 301 (-4.6A)
None
 1.14A 3elzB-4kptA:
undetectable		 3elzB-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 10 TYR A 111
ILE A 243
ILE A  53
GLY A  94
LEU A 231
 None
None
None
MES  A 301 (-4.6A)
None
 1.26A 3em0A-4kptA:
undetectable		 3em0A-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 12 GLY A  90
ILE A  91
ALA A  79
ASP A  89
VAL A  88
 None
None
None
PEG  A 310 (-3.2A)
None
 1.09A 3nvkI-4kptA:
undetectable		 3nvkI-4kptA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 12 ASN A 152
THR A 147
VAL A 185
ALA A 115
LEU A 116
 None
PEG  A 309 (-4.1A)
PEG  A 311 (-4.6A)
PEG  A 307 (-3.2A)
None
 1.11A 5kocA-4kptA:
undetectable		 5kocA-4kptA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		3 / 3 LYS A 246
GLN A  44
ASN A  45
 None
P6G  A 305 (-3.5A)
None
 0.86A 5l2tA-4kptA:
undetectable		 5l2tA-4kptA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN
(Lactococcus
lactis) 		5 / 10 MET A 216
PHE A 105
GLY A  90
ALA A  79
LEU A  80
 None
None
None
None
PG4  A 303 ( 4.2A)
 1.45A 5zjiA-4kptA:
undetectable
5zjiJ-4kptA:
undetectable		 5zjiA-4kptA:
16.05
5zjiJ-4kptA:
11.45