SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
5 / 12 ALA A 244
PHE A 280
PHE A 221
THR B 262
ILE B 260
None
1.21A 1dhfB-4kpuA:
2.2
1dhfB-4kpuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
4 / 6 LEU B 138
ILE B 105
ASP B 112
PRO B 172
None
1.14A 1ditH-4kpuB:
undetectable
1ditP-4kpuB:
undetectable
1ditH-4kpuB:
23.38
1ditP-4kpuB:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
4 / 8 CYH B   6
LEU B  42
ALA B  45
LEU B  46
FAD  B 301 (-4.8A)
None
None
None
0.94A 1hwiD-4kpuB:
undetectable
1hwiD-4kpuB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 11 LEU A 241
GLY A 247
GLY A 246
ILE A 278
TYR A 279
None
1.23A 1p91A-4kpuA:
undetectable
1p91A-4kpuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.98A 1sdtB-4kpuB:
undetectable
1sdtB-4kpuB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B 218
LEU B 211
PHE B  89
SER B  98
ASN B 103
None
1.01A 1xdsB-4kpuB:
undetectable
1xdsB-4kpuB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.90A 2avsB-4kpuB:
undetectable
2avsB-4kpuB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
5 / 9 ASP A  86
GLY B 137
ALA B 133
GLN B 140
THR A  85
None
CL  A 402 (-3.6A)
None
None
None
1.34A 2dtjA-4kpuA:
undetectable
2dtjB-4kpuA:
undetectable
2dtjA-4kpuA:
22.16
2dtjB-4kpuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 11 ASN A 234
ILE A 261
ALA A 254
SER A 252
ASP A 240
None
None
FAD  A 401 (-3.3A)
FAD  A 401 (-2.5A)
None
1.32A 2iyfA-4kpuA:
5.2
2iyfA-4kpuA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
5 / 12 ALA B 143
GLN B 140
ASP A 130
GLY A 116
ASP A 114
None
1.10A 2nv4B-4kpuB:
undetectable
2nv4B-4kpuB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.94A 2q5kB-4kpuB:
undetectable
2q5kB-4kpuB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
4 / 6 ILE A 261
ARG A 265
PRO A 276
SER A 297
None
1.11A 2qd3B-4kpuA:
1.8
2qd3B-4kpuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 122
ARG A 118
PRO B 111
VAL B 174
CL  A 402 ( 4.8A)
CL  A 402 (-4.3A)
None
None
1.40A 2qd4A-4kpuA:
2.3
2qd4A-4kpuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 PRO A 164
THR A 125
GLY A 126
THR B 221
LEU A 141
None
None
None
FAD  B 301 ( 4.2A)
None
1.16A 2uvnA-4kpuA:
undetectable
2uvnA-4kpuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
3 / 3 HIS A 290
MET A 311
MET A 294
FAD  A 401 (-3.9A)
None
None
1.32A 2vj1A-4kpuA:
undetectable
2vj1A-4kpuA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 ALA A 323
GLY A 226
GLY A 225
VAL A 301
ILE A 303
FAD  A 401 (-3.6A)
FAD  A 401 (-3.1A)
None
None
None
0.83A 3cyxB-4kpuA:
undetectable
3cyxB-4kpuA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY A 226
GLY A 228
ALA A 323
ASP A 257
VAL A 256
FAD  A 401 (-3.1A)
FAD  A 401 (-3.3A)
FAD  A 401 (-3.6A)
None
None
1.04A 3dmfA-4kpuA:
3.2
3dmfA-4kpuA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 10 CYH A 282
TYR A 279
VAL A 249
GLY A 225
GLY A 251
None
1.43A 3ixlA-4kpuA:
3.1
3ixlA-4kpuA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.11A 3keeB-4kpuA:
undetectable
3keeB-4kpuA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.06A 3keeD-4kpuA:
undetectable
3keeD-4kpuA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
4 / 8 VAL A 104
TYR A  99
ILE A  96
GLN A 100
None
0.95A 3remA-4kpuA:
undetectable
3remA-4kpuA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
4 / 8 VAL A 104
TYR A  99
ILE A  96
GLN A 100
None
0.97A 3remB-4kpuA:
undetectable
3remB-4kpuA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.09A 3sudB-4kpuA:
undetectable
3sudB-4kpuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.03A 3sueD-4kpuA:
undetectable
3sueD-4kpuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
4 / 7 ASP A 111
GLU A  20
PRO A 171
VAL A  27
None
1.06A 4hvrA-4kpuA:
undetectable
4hvrA-4kpuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
4 / 8 GLY A 151
ASN A 152
ARG B  27
ILE B 121
None
0.87A 4j4vC-4kpuA:
undetectable
4j4vC-4kpuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 11 ASP A 130
ALA B 120
TYR B  37
GLY A 151
GLY B 123
None
FAD  B 301 (-3.3A)
FAD  A 401 (-4.1A)
None
FAD  B 301 (-3.3A)
1.20A 4mm9A-4kpuA:
undetectable
4mm9A-4kpuA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
4 / 5 TYR B  37
ARG B 118
ASP A 130
VAL B 223
FAD  A 401 (-4.1A)
None
None
None
1.46A 4nkvB-4kpuB:
undetectable
4nkvB-4kpuB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 9 ASN B  35
ALA B 120
GLY A 150
ILE B  33
VAL B  10
FAD  B 301 (-4.3A)
FAD  B 301 (-3.3A)
None
None
None
1.08A 4nptA-4kpuB:
undetectable
4nptA-4kpuB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 9 PHE B 239
ALA B 247
ALA B 245
LEU B 251
VAL B 252
None
1.13A 4or0A-4kpuB:
undetectable
4or0A-4kpuB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 5 ASP A 114
LEU A 115
ARG A 122
THR B 142
None
None
CL  A 402 ( 4.8A)
None
1.44A 4p3qA-4kpuA:
undetectable
4p3qA-4kpuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 7 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.99A 4w5oA-4kpuA:
2.7
4w5oA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.97A 4w5qA-4kpuA:
2.9
4w5qA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.97A 4w5tA-4kpuA:
2.6
4w5tA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
1.01A 4z4cA-4kpuA:
2.8
4z4cA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.97A 4z4dA-4kpuA:
3.2
4z4dA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 7 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.97A 4z4eA-4kpuA:
undetectable
4z4eA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 7 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.99A 4z4gA-4kpuA:
2.5
4z4gA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 9 THR A 299
ILE A 300
GLY A 318
LEU A 330
LEU A 241
None
1.25A 4ze0A-4kpuA:
undetectable
4ze0A-4kpuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
3 / 3 VAL B   5
GLN B  39
CYH B  73
None
0.69A 5icxC-4kpuB:
undetectable
5icxF-4kpuB:
undetectable
5icxC-4kpuB:
22.69
5icxF-4kpuB:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 CYH B 116
GLY B 117
TYR B  37
TYR B  40
LEU B 113
FAD  B 301 (-4.0A)
FAD  B 301 (-3.3A)
FAD  A 401 (-4.1A)
None
None
1.38A 5kklB-4kpuB:
undetectable
5kklB-4kpuB:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
3 / 3 THR A 125
PRO B 220
ASP B  93
None
None
FAD  B 301 (-4.0A)
0.93A 5l8dB-4kpuA:
undetectable
5l8dB-4kpuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
4 / 7 TYR A  18
ILE A 106
MET A 166
ILE A  96
None
0.82A 5murB-4kpuA:
undetectable
5murB-4kpuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
3 / 3 THR A 125
PRO B 220
ASP B  93
None
None
FAD  B 301 (-4.0A)
0.93A 5mwuB-4kpuA:
undetectable
5mwuB-4kpuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
5 / 11 GLU A 262
SER B 164
ARG A 204
VAL B 155
VAL B 147
None
1.36A 5whyA-4kpuA:
2.3
5whyA-4kpuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
5 / 11 GLU A 262
SER B 164
THR B 166
VAL B 155
VAL B 147
None
1.31A 5whyA-4kpuA:
2.3
5whyA-4kpuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.11A 6c2mB-4kpuA:
undetectable
6c2mB-4kpuA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
1.06A 6c2mD-4kpuA:
undetectable
6c2mD-4kpuA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
4 / 6 ARG A 204
CYH A 202
ILE A 203
ASP B 159
None
0.95A 6cbdA-4kpuA:
2.6
6cbdA-4kpuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.93A 6dh0A-4kpuB:
undetectable
6dh0A-4kpuB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.93A 6dh6A-4kpuB:
undetectable
6dh6A-4kpuB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans)
5 / 12 GLY B  77
ALA B  78
ASP B  79
VAL B   5
ILE B   3
None
0.95A 6dj2B-4kpuB:
undetectable
6dj2B-4kpuB:
16.03