SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 5 ASP A 381
HIS A 111
HIS A 105
HIS A 109
 None
PO4  A 603 (-4.0A)
None
PO4  A 603 (-3.6A)
 1.10A 1ei6A-4kq8A:
undetectable		 1ei6A-4kq8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 7 LEU A 372
THR A  94
SER A  98
VAL A  87
 None
 0.74A 1tyrB-4kq8A:
undetectable		 1tyrB-4kq8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ILE A 132
ASN A 135
LEU A 122
CYH A 299
ARG A 115
 HEM  A 601 (-3.8A)
None
None
None
HEM  A 601 ( 2.6A)
 1.31A 2bxfB-4kq8A:
undetectable		 2bxfB-4kq8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ALA A 254
ASP A 253
ASP A 250
ILE A 300
LEU A 196
 None
 1.00A 2o4nA-4kq8A:
undetectable		 2o4nA-4kq8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 6 ASP A 384
ILE A  97
LEU A 396
GLU A 405
 None
 1.08A 2ya7B-4kq8A:
undetectable		 2ya7B-4kq8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ALA A 254
ASP A 253
ASP A 250
ILE A 300
ILE A 213
 None
 0.93A 3cywA-4kq8A:
undetectable		 3cywA-4kq8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		3 / 3 ALA A 306
THR A 310
CYH A 437
 HEM  A 601 ( 3.6A)
ASD  A 602 (-3.9A)
HEM  A 601 (-2.3A)
 0.69A 3e4eB-4kq8A:
37.0		 3e4eB-4kq8A:
28.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		10 / 10 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.23A 3eqmA-4kq8A:
64.6		 3eqmA-4kq8A:
92.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		3 / 3 MET A 444
CYH A 437
PRO A 429
 None
HEM  A 601 (-2.3A)
None
 1.14A 3h52C-4kq8A:
0.9		 3h52C-4kq8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ALA A 254
ASP A 253
ASP A 250
ILE A 300
ILE A 213
 None
 0.94A 3jvyA-4kq8A:
undetectable		 3jvyA-4kq8A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 7 SER A 478
VAL A 370
ARG A 115
PHE A 134
 None
HEM  A 601 (-4.4A)
HEM  A 601 ( 2.6A)
None
 1.23A 3n5tA-4kq8A:
undetectable
3n5tB-4kq8A:
undetectable		 3n5tA-4kq8A:
20.77
3n5tB-4kq8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 5 PHE A 317
ILE A 471
PHE A 320
PHE A 316
 None
 1.00A 3owxB-4kq8A:
undetectable		 3owxB-4kq8A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		12 / 12 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 370
LEU A 372
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
None
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.20A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 369
 ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
None
 1.27A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ALA A 306
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.24A 3s7sA-4kq8A:
64.3		 3s7sA-4kq8A:
92.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 SER A 211
ASP A 209
ASP A 197
GLU A 177
GLU A 176
 None
 1.43A 4dfuB-4kq8A:
undetectable		 4dfuB-4kq8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 6 ARG A 457
ILE A 450
VAL A 194
LEU A 190
 None
 1.10A 4em2A-4kq8A:
1.2		 4em2A-4kq8A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 VAL A 185
PHE A 316
LEU A 315
LEU A 319
LEU A 172
 None
 1.13A 4i1rA-4kq8A:
undetectable		 4i1rA-4kq8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 6 MET A 160
MET A 446
ILE A 132
ILE A 133
 None
None
HEM  A 601 (-3.8A)
ASD  A 602 (-4.0A)
 0.91A 4olmA-4kq8A:
1.7		 4olmA-4kq8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 5 GLU A 416
GLU A 362
TYR A 366
GLU A 412
 None
 1.31A 4r87E-4kq8A:
undetectable		 4r87E-4kq8A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 7 GLU A 416
GLU A 362
TYR A 366
GLU A 412
 None
 1.35A 4r87I-4kq8A:
undetectable		 4r87I-4kq8A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 LEU A 319
ILE A 333
ARG A 495
VAL A 194
LEU A 191
 None
 1.01A 4y8wC-4kq8A:
37.9		 4y8wC-4kq8A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JKV_A_ASDA602_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		12 / 12 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 370
LEU A 372
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
None
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.24A 5jkvA-4kq8A:
64.4		 5jkvA-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JKW_A_TESA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		11 / 11 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
VAL A 373
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.0A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.22A 5jkwA-4kq8A:
64.4		 5jkwA-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL6_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.25A 5jl6A-4kq8A:
64.5		 5jl6A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL7_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		10 / 10 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.23A 5jl7A-4kq8A:
64.5		 5jl7A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL9_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.22A 5jl9A-4kq8A:
64.4		 5jl9A-4kq8A:
92.05