SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 ILE A 294
GLY A 293
GLY A  69
ILE A  66
ALA A  74
 None
 0.90A 1vq1B-4kq9A:
undetectable		 1vq1B-4kq9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 11 GLY A 278
ILE A 320
MET A 329
LEU A 272
ALA A 274
 None
 1.03A 1x7pA-4kq9A:
3.5
1x7pB-4kq9A:
4.3		 1x7pA-4kq9A:
24.65
1x7pB-4kq9A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		3 / 3 SER A  54
VAL A 132
LEU A 108
 None
 0.69A 1yajG-4kq9A:
undetectable		 1yajG-4kq9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 ALA A 243
ASP A 240
GLY A 239
GLY A 264
ALA A 271
 None
 1.15A 2c49A-4kq9A:
6.0		 2c49A-4kq9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 ALA A 295
ASP A 137
PHE A 148
GLY A 292
ILE A  66
 None
GOL  A 502 (-2.8A)
GOL  A 503 ( 4.8A)
None
None
 1.29A 2dcfA-4kq9A:
undetectable		 2dcfA-4kq9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_H_RBFH201_1
(IMMUNOGLOBULIN IGG1
HEAVY CHAIN
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 9 GLU A 187
ARG A 194
GLU A 191
VAL A 174
TYR A 236
 None
 1.39A 2fl5D-4kq9A:
0.0
2fl5H-4kq9A:
0.0
2fl5L-4kq9A:
0.0		 2fl5D-4kq9A:
21.26
2fl5H-4kq9A:
21.26
2fl5L-4kq9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 8 THR A 265
VAL A 284
ALA A 161
GLN A 189
 None
 1.06A 2ij7C-4kq9A:
undetectable		 2ij7C-4kq9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 7 GLY A 150
THR A 315
GLN A 286
PHE A  62
PHE A  63
 None
None
GOL  A 502 (-3.4A)
GOL  A 502 ( 4.5A)
None
 1.19A 2qx4A-4kq9A:
4.9
2qx4B-4kq9A:
4.9		 2qx4A-4kq9A:
21.55
2qx4B-4kq9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 11 ALA A 295
ASP A 137
PHE A 148
GLY A 292
ILE A  66
 None
GOL  A 502 (-2.8A)
GOL  A 503 ( 4.8A)
None
None
 1.28A 2zmaA-4kq9A:
undetectable		 2zmaA-4kq9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 5 LEU A 135
ILE A 313
ILE A 109
GLY A 292
 None
 0.94A 3bufA-4kq9A:
undetectable		 3bufA-4kq9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 9 GLY A 124
ALA A 125
ASP A 128
ILE A  94
VAL A 132
 None
 1.02A 3u7sB-4kq9A:
undetectable		 3u7sB-4kq9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 5 LEU A 244
GLY A 245
THR A 222
VAL A 177
 None
 1.04A 3wrkD-4kq9A:
undetectable		 3wrkD-4kq9A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 GLY A 150
SER A 151
ILE A 294
ALA A 295
VAL A 298
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.03A 4dx5B-4kq9A:
undetectable		 4dx5B-4kq9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		6 / 12 VAL A 232
GLY A 246
GLY A 242
ILE A 235
ILE A 250
LEU A 226
 None
 1.45A 4iv0A-4kq9A:
undetectable		 4iv0A-4kq9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 GLY A 246
GLY A 242
ILE A 235
ILE A 250
LEU A 226
 None
 0.94A 4mwzB-4kq9A:
undetectable		 4mwzB-4kq9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		3 / 3 SER A 111
ASP A 137
GLN A 286
 None
GOL  A 502 (-2.8A)
GOL  A 502 (-3.4A)
 0.85A 4oltA-4kq9A:
undetectable
4oltB-4kq9A:
undetectable		 4oltA-4kq9A:
27.24
4oltB-4kq9A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 7 PHE A 153
GLN A 189
THR A 265
ASP A 266
 GOL  A 502 ( 4.7A)
None
None
GOL  A 502 ( 4.3A)
 1.04A 4pcuA-4kq9A:
2.6		 4pcuA-4kq9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 6 GLY A 264
GLN A 189
PHE A 185
ILE A 156
 None
None
GOL  A 502 (-3.9A)
None
 1.07A 4qogA-4kq9A:
6.1
4qogB-4kq9A:
6.0		 4qogA-4kq9A:
21.19
4qogB-4kq9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		3 / 3 GLN A 286
SER A 111
ASP A 137
 GOL  A 502 (-3.4A)
None
GOL  A 502 (-2.8A)
 0.81A 4qwpA-4kq9A:
undetectable
4qwpB-4kq9A:
undetectable		 4qwpA-4kq9A:
27.24
4qwpB-4kq9A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 GLY A 150
SER A 151
ILE A 294
ALA A 295
VAL A 298
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.04A 4u8vB-4kq9A:
undetectable		 4u8vB-4kq9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 GLY A 150
SER A 151
ILE A 294
ALA A 295
VAL A 298
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.05A 4u8yB-4kq9A:
undetectable		 4u8yB-4kq9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 12 GLY A 150
SER A 151
ILE A 294
ALA A 295
VAL A 298
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.02A 4u95B-4kq9A:
undetectable		 4u95B-4kq9A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 9 ALA A 295
ILE A  66
GLY A  69
VAL A  52
ILE A 109
 None
 1.12A 5kr0A-4kq9A:
undetectable		 5kr0A-4kq9A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(Conexibacter
woesei) 		5 / 10 ALA A 212
ASP A 266
SER A 285
VAL A 186
ASP A 137
 None
GOL  A 502 ( 4.3A)
None
None
GOL  A 502 (-2.8A)
 1.29A 6clxB-4kq9A:
3.4		 6clxB-4kq9A:
22.51