SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		5 / 12 PHE A 392
LEU A 447
LEU A 438
ALA A 220
ILE A 462
 None
 1.08A 1crbA-4kqbA:
undetectable		 1crbA-4kqbA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		5 / 11 TYR A 332
GLU A 468
TRP A 326
ASP A 366
HIS A 465
 None
None
None
MN  A 606 (-4.5A)
None
 1.33A 1u65A-4kqbA:
undetectable		 1u65A-4kqbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 7 TYR A 343
TYR A 332
TYR A 313
ILE A 411
 None
 1.26A 2ph9A-4kqbA:
undetectable
2ph9B-4kqbA:
undetectable		 2ph9A-4kqbA:
19.71
2ph9B-4kqbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 8 TYR A 343
SER A 415
THR A 416
LEU A 406
 None
 1.17A 2v0zO-4kqbA:
undetectable		 2v0zO-4kqbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		5 / 10 ALA A 189
LEU A 160
ILE A 234
ILE A 153
PHE A 137
 None
None
ADP  A 608 ( 4.6A)
None
None
 1.17A 2w9sC-4kqbA:
undetectable		 2w9sC-4kqbA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 MET A 171
GLU A 213
ASN A 364
 None
MN  A 606 ( 3.0A)
None
 1.08A 3a27A-4kqbA:
undetectable		 3a27A-4kqbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 TYR A 275
ASP A 366
HIS A 206
 None
MN  A 606 (-4.5A)
None
 0.84A 3e23A-4kqbA:
undetectable		 3e23A-4kqbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		5 / 12 ALA A 460
LEU A  90
ASP A 398
SER A  85
GLU A 456
 None
 1.05A 3g2oB-4kqbA:
undetectable		 3g2oB-4kqbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 7 ASP A 387
ASP A 366
GLN A 365
GLU A 213
 MN  A 606 (-2.5A)
MN  A 606 (-4.5A)
None
MN  A 606 ( 3.0A)
 1.25A 3l2vA-4kqbA:
undetectable		 3l2vA-4kqbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 TYR A 208
ASP A 399
ASP A 359
 None
 0.78A 3ou7B-4kqbA:
undetectable		 3ou7B-4kqbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 7 LEU A 358
ARG A 367
THR A 221
GLY A 363
 None
 0.94A 4eqlA-4kqbA:
undetectable		 4eqlA-4kqbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 7 LEU A 358
ARG A 367
THR A 221
GLY A 363
 None
 0.96A 4eqlB-4kqbA:
undetectable		 4eqlB-4kqbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 PRO A 453
MET A 455
TYR A 452
 None
 1.04A 4qa2B-4kqbA:
undetectable		 4qa2B-4kqbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 5 TYR A 147
PHE A 373
HIS A 385
LEU A 386
 None
None
None
ADP  A 608 ( 4.6A)
 1.39A 5csyB-4kqbA:
undetectable		 5csyB-4kqbA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		4 / 7 HIS A 368
THR A 175
TYR A 275
HIS A 369
 None
ADP  A 608 (-4.6A)
None
None
 1.31A 5iy5A-4kqbA:
undetectable
5iy5C-4kqbA:
undetectable		 5iy5A-4kqbA:
17.85
5iy5C-4kqbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 SER A 439
HIS A 435
TYR A 449
 None
 1.03A 5y2tA-4kqbA:
undetectable		 5y2tA-4kqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4kqb PROTEIN H03A11.1
(Caenorhabditis
elegans) 		3 / 3 ASP A 359
LEU A 358
ARG A 232
 None
 0.89A 7dfrA-4kqbA:
undetectable		 7dfrA-4kqbA:
15.79