SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		4 / 5 ASN A 234
ALA A 236
ASP A 272
GLU A 235
 None
 1.38A 1lqtA-4kqcA:
3.3
1lqtB-4kqcA:
3.1		 1lqtA-4kqcA:
25.86
1lqtB-4kqcA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		4 / 5 ASN A 234
ALA A 236
ASP A 272
GLU A 235
 None
 1.36A 1lquA-4kqcA:
3.2
1lquB-4kqcA:
4.7		 1lquA-4kqcA:
25.86
1lquB-4kqcA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 9 GLY A 229
GLY A 264
GLY A 263
ASP A 262
ARG A 152
 None
 1.03A 1mxdA-4kqcA:
undetectable		 1mxdA-4kqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 11 GLY A 229
GLY A 264
GLY A 263
ASP A 262
ARG A 152
 None
 1.04A 1mxgA-4kqcA:
undetectable		 1mxgA-4kqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 12 GLY A 112
ILE A 297
ALA A  47
ILE A  87
PHE A  60
 None
 1.16A 1ve3B-4kqcA:
undetectable		 1ve3B-4kqcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 12 PHE A  39
ALA A 138
ALA A 321
GLY A 177
GLY A 181
 None
None
NO3  A 504 (-3.7A)
None
None
 1.12A 2igtA-4kqcA:
2.2		 2igtA-4kqcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 12 PHE A  39
ALA A 138
ALA A 321
GLY A 177
GLY A 181
 None
None
NO3  A 504 (-3.7A)
None
None
 1.09A 2igtB-4kqcA:
undetectable		 2igtB-4kqcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		3 / 3 TYR A 339
TYR A 324
GLY A 274
 None
 0.74A 3eteB-4kqcA:
1.9
3eteD-4kqcA:
5.0
3eteF-4kqcA:
2.2		 3eteB-4kqcA:
20.65
3eteD-4kqcA:
20.65
3eteF-4kqcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		5 / 12 THR A 319
TYR A 339
LEU A 278
SER A 273
ILE A 329
 None
 1.27A 3frqA-4kqcA:
0.8		 3frqA-4kqcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		3 / 3 SER A 172
GLY A 175
SER A 115
 None
 0.62A 3loqA-4kqcA:
2.3		 3loqA-4kqcA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		3 / 3 GLY A 270
SER A 289
TRP A 323
 None
 0.95A 4e7cD-4kqcA:
undetectable		 4e7cD-4kqcA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		4 / 8 ALA A 305
ALA A 301
ALA A  47
ALA A  51
 None
 0.78A 4twdF-4kqcA:
undetectable
4twdG-4kqcA:
undetectable
4twdH-4kqcA:
undetectable
4twdI-4kqcA:
undetectable
4twdJ-4kqcA:
undetectable		 4twdF-4kqcA:
23.16
4twdG-4kqcA:
23.16
4twdH-4kqcA:
23.16
4twdI-4kqcA:
23.16
4twdJ-4kqcA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Brachyspira
murdochii) 		4 / 5 ILE A 297
PHE A  60
SER A  32
ALA A 301
 None
 1.25A 5msdA-4kqcA:
4.4		 5msdA-4kqcA:
15.09