SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		5 / 12 ILE A 189
GLY A 184
GLY A 156
SER A 155
PRO A 140
 None
 0.99A 1vq1B-4kqxA:
5.0		 1vq1B-4kqxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		5 / 9 THR A 113
VAL A 133
LEU A 108
ALA A  81
ALA A  84
 None
 1.43A 3ax7B-4kqxA:
undetectable		 3ax7B-4kqxA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		3 / 3 GLY A  50
SER A  49
TRP A 180
 None
 0.99A 4e7cD-4kqxA:
undetectable		 4e7cD-4kqxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 6 ARG A 148
ILE A  32
VAL A  53
LEU A  72
 None
 1.08A 4em2A-4kqxA:
undetectable		 4em2A-4kqxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 4 LYS A 191
LEU A  15
ALA A 161
VAL A 163
 None
 1.03A 4ik6A-4kqxA:
undetectable		 4ik6A-4kqxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 7 LYS A 191
LEU A  15
ALA A 161
VAL A 163
 None
 0.93A 4ik7A-4kqxA:
undetectable		 4ik7A-4kqxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		3 / 3 LYS A 191
LEU A  15
ALA A 161
 None
 0.54A 4ikiA-4kqxA:
undetectable		 4ikiA-4kqxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 5 VAL A  89
LEU A 114
VAL A 135
PHE A 116
 None
 0.95A 4lb0B-4kqxA:
undetectable		 4lb0B-4kqxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		5 / 12 GLY A 188
GLY A 156
GLU A 196
ASP A 159
LEU A 160
 None
 1.13A 5c0oE-4kqxA:
4.8		 5c0oE-4kqxA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 5 LYS A 191
LEU A  15
ALA A 161
VAL A 163
 None
 1.10A 5cr1A-4kqxA:
undetectable		 5cr1A-4kqxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		5 / 10 ILE A  33
GLY A  34
GLY A  39
VAL A  53
ALA A  80
 None
NAD  A 401 (-3.7A)
None
None
None
 1.04A 5o96C-4kqxA:
2.4
5o96D-4kqxA:
undetectable		 5o96C-4kqxA:
20.17
5o96D-4kqxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4kqx KETOL-ACID
REDUCTOISOMERASE
(Slackia
exigua) 		4 / 8 VAL A 246
ASN A 258
ILE A 254
GLU A 269
 None
 1.08A 6hzpA-4kqxA:
undetectable		 6hzpA-4kqxA:
20.88