SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 6 ILE A 360
SER A 302
ASN A 299
THR A 296
 None
 1.06A 1h7xA-4kr9A:
2.6		 1h7xA-4kr9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 6 ILE A 360
SER A 302
ASN A 299
THR A 296
 None
 1.07A 1h7xB-4kr9A:
2.3		 1h7xB-4kr9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 6 ILE A 360
SER A 302
ASN A 299
THR A 296
 None
 1.05A 1h7xC-4kr9A:
undetectable		 1h7xC-4kr9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 6 ILE A 360
SER A 302
ASN A 299
THR A 296
 None
 1.04A 1h7xD-4kr9A:
2.2		 1h7xD-4kr9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LYS A  60
THR A 332
SER A 231
GLU A 202
 None
 1.43A 1xr2B-4kr9A:
undetectable		 1xr2B-4kr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 11 SER A 182
SER A 187
THR A 285
GLY A 286
GLN A 295
 None
 0.74A 2hmaA-4kr9A:
12.1		 2hmaA-4kr9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 10 ASP A 161
ILE A  67
CYH A 165
LEU A  61
ASP A  58
 None
 1.43A 3m0wC-4kr9A:
undetectable
3m0wD-4kr9A:
undetectable
3m0wE-4kr9A:
undetectable
3m0wF-4kr9A:
undetectable		 3m0wC-4kr9A:
12.24
3m0wD-4kr9A:
12.24
3m0wE-4kr9A:
12.24
3m0wF-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 9 LEU A  61
ASP A  58
ILE A  67
CYH A 165
ASP A 161
 None
 1.49A 3m0wC-4kr9A:
undetectable
3m0wD-4kr9A:
undetectable
3m0wE-4kr9A:
undetectable
3m0wF-4kr9A:
undetectable		 3m0wC-4kr9A:
12.24
3m0wD-4kr9A:
12.24
3m0wE-4kr9A:
12.24
3m0wF-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 9 ASP A 161
ILE A  67
CYH A 165
LEU A  61
ASP A  58
 None
 1.40A 3m0wG-4kr9A:
undetectable
3m0wH-4kr9A:
undetectable
3m0wI-4kr9A:
undetectable
3m0wJ-4kr9A:
undetectable		 3m0wG-4kr9A:
12.24
3m0wH-4kr9A:
12.24
3m0wI-4kr9A:
12.24
3m0wJ-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A  61
ASP A  58
ILE A  67
CYH A 165
ASP A 161
 None
 1.49A 3m0wE-4kr9A:
undetectable
3m0wF-4kr9A:
undetectable
3m0wG-4kr9A:
undetectable
3m0wH-4kr9A:
undetectable		 3m0wE-4kr9A:
12.24
3m0wF-4kr9A:
12.24
3m0wG-4kr9A:
12.24
3m0wH-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A  61
ASP A  58
ILE A  67
CYH A 165
ASP A 161
 None
 1.46A 3m0wA-4kr9A:
undetectable
3m0wB-4kr9A:
undetectable
3m0wI-4kr9A:
undetectable
3m0wJ-4kr9A:
undetectable		 3m0wA-4kr9A:
12.24
3m0wB-4kr9A:
12.24
3m0wI-4kr9A:
12.24
3m0wJ-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A  91
ILE A 129
ILE A 121
VAL A 149
VAL A 105
 None
None
None
None
A  M  39 ( 4.1A)
 0.97A 3me6A-4kr9A:
undetectable		 3me6A-4kr9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A  48
GLY A 148
VAL A 149
VAL A   6
ILE A   8
 None
 1.01A 3oxwD-4kr9A:
undetectable		 3oxwD-4kr9A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 6 VAL A   9
LEU A  61
ILE A  64
VAL A  40
 None
 0.87A 4a9kA-4kr9A:
undetectable		 4a9kA-4kr9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A  29
LYS A  41
LYS A  39
 None
 1.08A 4k50A-4kr9A:
undetectable		 4k50A-4kr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A  29
LYS A  41
LYS A  39
 None
 1.08A 4k50E-4kr9A:
undetectable		 4k50E-4kr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A  29
LYS A  41
LYS A  39
 None
 1.12A 4k50I-4kr9A:
undetectable		 4k50I-4kr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 8 ARG A 152
ARG A  46
ARG A  10
ARG A 162
 C  M  30 ( 2.8A)
None
None
C  M  31 ( 4.6A)
 1.34A 4kr4C-4kr9A:
undetectable		 4kr4C-4kr9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 5 HIS A 239
VAL A 204
GLU A 202
VAL A 384
 None
 1.42A 4p6vB-4kr9A:
undetectable
4p6vE-4kr9A:
undetectable		 4p6vB-4kr9A:
22.60
4p6vE-4kr9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 5 SER A 208
GLN A 247
LEU A 248
PHE A 347
 None
 1.48A 5evyX-4kr9A:
undetectable		 5evyX-4kr9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 265
ILE A 303
SER A 302
 None
 0.85A 5zw2A-4kr9A:
undetectable		 5zw2A-4kr9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLN A 341
ILE A 223
THR A 332
TYR A 333
 None
 0.84A 6cduG-4kr9A:
undetectable
6cduH-4kr9A:
undetectable		 6cduG-4kr9A:
19.46
6cduH-4kr9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PHE A 268
ARG A 313
ALA A 282
 None
 0.94A 6ecfB-4kr9A:
undetectable		 6ecfB-4kr9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4kr9 PROBABLE TRNA
SULFURTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LEU A 364
GLN A 367
LYS A 257
 None
 0.98A 6exiB-4kr9A:
undetectable		 6exiB-4kr9A:
11.08