SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4krc PHO85 CYCLIN-10
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 328
VAL B 367
HIS B 379
CYH B 321
 None
 0.88A 1ekjA-4krcB:
undetectable
1ekjB-4krcB:
undetectable		 1ekjA-4krcB:
21.03
1ekjB-4krcB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4krc PHO85 CYCLIN-10
(Saccharomyces
cerevisiae) 		5 / 9 VAL B 406
LEU B 411
ILE B 335
ALA B 366
LEU B 369
 None
 1.19A 1eqgA-4krcB:
undetectable		 1eqgA-4krcB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4krc PHO85 CYCLIN-10
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 403
GLU B 399
SER B 370
LEU B 369
VAL B 367
 None
 1.25A 2c12C-4krcB:
undetectable		 2c12C-4krcB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4krc PHO85 CYCLIN-10
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 403
LEU B 374
SER B 370
LEU B 369
VAL B 367
 None
 1.14A 2c12C-4krcB:
undetectable		 2c12C-4krcB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4krc PHO85 CYCLIN-10
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 406
LEU B 338
LEU B 411
ALA B 366
LEU B 369
 None
 1.07A 3pghD-4krcB:
undetectable		 3pghD-4krcB:
16.55