SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.42A 1axwB-4krfA:
undetectable		 1axwB-4krfA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 LEU A 640
PHE A  21
TYR A 702
LEU A 592
HIS A 679
 None
 1.19A 1brpA-4krfA:
undetectable		 1brpA-4krfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA181_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 THR A 711
ARG A 205
HIS A 709
HIS A 710
 None
None
None
G  R   8 ( 4.5A)
 1.46A 1gtnA-4krfA:
0.0		 1gtnA-4krfA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.38A 1ju6A-4krfA:
undetectable		 1ju6A-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.38A 1ju6C-4krfA:
undetectable		 1ju6C-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.35A 1jujA-4krfA:
undetectable		 1jujA-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.35A 1jujB-4krfA:
undetectable		 1jujB-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.35A 1jujC-4krfA:
undetectable		 1jujC-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.35A 1jujD-4krfA:
undetectable		 1jujD-4krfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.24A 1kt4A-4krfA:
undetectable		 1kt4A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.26A 1kt6A-4krfA:
undetectable		 1kt6A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.24A 1kt7A-4krfA:
undetectable		 1kt7A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 LEU A 748
ALA A  23
LEU A 777
GLN A 778
HIS A 740
 None
 1.42A 1kt7A-4krfA:
undetectable		 1kt7A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 7 PHE A 440
ALA A 479
ILE A 565
ILE A 483
 None
 0.99A 1oniD-4krfA:
1.7
1oniF-4krfA:
2.1		 1oniD-4krfA:
11.71
1oniF-4krfA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 LEU A 154
MET A 140
LEU A 141
GLN A 158
 None
 1.05A 1p93D-4krfA:
undetectable		 1p93D-4krfA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 ALA A 219
THR A 366
PHE A 222
 A  R   7 ( 3.6A)
A  R   7 ( 3.5A)
None
 0.67A 2c6nB-4krfA:
undetectable		 2c6nB-4krfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 LEU A 323
PRO A 324
LEU A 339
 None
 0.47A 2po7B-4krfA:
4.8		 2po7B-4krfA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 LEU A 323
PRO A 324
LEU A 339
ILE A 229
 None
 0.70A 2qd4A-4krfA:
4.8		 2qd4A-4krfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 TYR A 223
GLU A 259
THR A 355
 None
 1.04A 2y7hB-4krfA:
undetectable		 2y7hB-4krfA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 PRO A 741
MET A 211
LEU A 145
LEU A 154
ALA A 159
 None
 1.06A 3a50D-4krfA:
undetectable		 3a50D-4krfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 ASP A 595
PHE A 809
SER A 608
 None
 0.91A 3i5uB-4krfA:
2.2		 3i5uB-4krfA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 VAL A 204
LEU A 213
ILE A 397
ALA A 163
 None
 0.95A 3n8yB-4krfA:
undetectable		 3n8yB-4krfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 VAL A 596
HIS A 598
SER A 608
THR A 610
 None
 0.74A 3tj7A-4krfA:
undetectable
3tj7B-4krfA:
undetectable		 3tj7A-4krfA:
13.22
3tj7B-4krfA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 VAL A 596
HIS A 598
SER A 608
THR A 610
 None
 0.70A 3tj7C-4krfA:
undetectable
3tj7D-4krfA:
undetectable		 3tj7C-4krfA:
13.22
3tj7D-4krfA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 VAL A 596
HIS A 598
SER A 608
THR A 610
 None
 0.70A 3tj7C-4krfA:
undetectable
3tj7D-4krfA:
undetectable		 3tj7C-4krfA:
13.22
3tj7D-4krfA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 LEU A 213
ILE A 397
TYR A 386
ILE A 215
LEU A 160
 None
 1.29A 3vw1B-4krfA:
undetectable		 3vw1B-4krfA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 7 PRO A 729
ILE A 728
GLY A 408
VAL A 734
 None
 0.97A 4a3uB-4krfA:
2.4		 4a3uB-4krfA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 LEU A 777
LEU A 780
LEU A 784
CYH A 785
ILE A 663
 None
 0.80A 4a7aB-4krfA:
undetectable		 4a7aB-4krfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 8 PHE A  21
HIS A 679
GLU A 681
ILE A 700
 None
 1.25A 4cx7A-4krfA:
undetectable
4cx7B-4krfA:
undetectable		 4cx7A-4krfA:
18.82
4cx7B-4krfA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.21A 4f3tA-4krfA:
64.3		 4f3tA-4krfA:
82.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 LEU A 648
TYR A 652
LEU A 692
TYR A 696
 None
 0.37A 4f3tA-4krfA:
64.3		 4f3tA-4krfA:
82.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 LEU A 323
PRO A 324
LEU A 339
ILE A 229
 None
 0.68A 4f4dB-4krfA:
5.2		 4f4dB-4krfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.32A 4foxE-4krfA:
undetectable		 4foxE-4krfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.29A 4foxF-4krfA:
undetectable		 4foxF-4krfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 11 ILE A 516
ASP A 535
GLY A 534
PHE A 503
TYR A 855
 None
 1.30A 4foxH-4krfA:
undetectable		 4foxH-4krfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 LEU A 323
PRO A 324
LEU A 339
ILE A 229
 None
 0.72A 4klrA-4krfA:
4.9		 4klrA-4krfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 MET A 164
LEU A 160
ARG A 205
SER A 169
 None
 1.29A 4kmmB-4krfA:
4.0		 4kmmB-4krfA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 ARG A  88
GLU A 394
PHE A 395
 None
 0.87A 4kszA-4krfA:
undetectable		 4kszA-4krfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 CYH A 562
PRO A 555
ASP A 478
 None
 1.02A 4pm5A-4krfA:
undetectable		 4pm5A-4krfA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 LEU A 648
ILE A 649
LEU A 692
TYR A 696
 None
 0.40A 4w5nA-4krfA:
59.7		 4w5nA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		7 / 7 ARG A 686
CYH A 689
ILE A 690
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.25A 4w5oA-4krfA:
59.7		 4w5oA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
 None
 0.21A 4w5oA-4krfA:
59.7		 4w5oA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
U  R   1 ( 3.2A)
None
None
None
 0.16A 4w5oA-4krfA:
59.7		 4w5oA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.30A 4w5qA-4krfA:
53.7		 4w5qA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.42A 4w5qA-4krfA:
53.7		 4w5qA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.20A 4w5qA-4krfA:
53.7		 4w5qA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.16A 4w5qA-4krfA:
53.8		 4w5qA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.28A 4w5rA-4krfA:
62.5		 4w5rA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.13A 4w5rA-4krfA:
62.5		 4w5rA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.46A 4w5tA-4krfA:
49.4		 4w5tA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.30A 4w5tA-4krfA:
49.4		 4w5tA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.16A 4w5tA-4krfA:
49.4		 4w5tA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 LYS A 352
ARG A 278
VAL A 279
 None
 0.97A 4x3uA-4krfA:
undetectable
4x3uB-4krfA:
undetectable		 4x3uA-4krfA:
5.64
4x3uB-4krfA:
5.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.34A 4z4cA-4krfA:
59.6		 4z4cA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.40A 4z4cA-4krfA:
59.6		 4z4cA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
 None
 0.22A 4z4cA-4krfA:
59.6		 4z4cA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.15A 4z4cA-4krfA:
59.6		 4z4cA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.23A 4z4dA-4krfA:
59.9		 4z4dA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
 None
 0.24A 4z4dA-4krfA:
59.9		 4z4dA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
U  R   1 ( 3.2A)
None
None
None
 0.16A 4z4dA-4krfA:
59.9		 4z4dA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		7 / 7 ARG A 686
CYH A 689
ILE A 690
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.26A 4z4eA-4krfA:
59.9		 4z4eA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
 None
 0.23A 4z4eA-4krfA:
59.9		 4z4eA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
U  R   1 ( 3.2A)
None
None
None
 0.14A 4z4eA-4krfA:
59.9		 4z4eA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 7 LEU A 648
TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.35A 4z4fA-4krfA:
61.7		 4z4fA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 VAL A 589
ALA A 618
PHE A 651
THR A 655
 None
 0.26A 4z4fA-4krfA:
61.7		 4z4fA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.17A 4z4fA-4krfA:
61.7		 4z4fA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		7 / 7 ARG A 686
CYH A 689
ILE A 690
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.23A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 6 LEU A 648
TYR A 652
PRO A 659
TYR A 696
 None
 0.33A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.24A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ASP A 535
ALA A 541
THR A 850
THR A 853
TYR A 855
 None
 0.12A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 VAL A 589
ALA A 618
PHE A 651
THR A 655
 None
 0.24A 4z4hA-4krfA:
60.0		 4z4hA-4krfA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ARG A 686
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.30A 4z4hA-4krfA:
60.0		 4z4hA-4krfA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ASP A 535
ALA A 541
LYS A 568
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
 0.14A 4z4hA-4krfA:
60.0		 4z4hA-4krfA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 VAL A 589
ALA A 618
PHE A 651
 None
 0.16A 4z4iA-4krfA:
55.1		 4z4iA-4krfA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.20A 4z4iA-4krfA:
55.1		 4z4iA-4krfA:
82.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 10 ARG A 171
PHE A 200
LEU A 213
ILE A 215
ALA A 384
 None
 1.36A 4z69I-4krfA:
undetectable		 4z69I-4krfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 7 GLU A 681
TYR A 702
ASP A 595
ALA A 594
 None
 1.00A 4zz8A-4krfA:
undetectable		 4zz8A-4krfA:
9.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		3 / 3 VAL A 589
ALA A 618
PHE A 651
 None
 0.22A 5js1A-4krfA:
63.5		 5js1A-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 LEU A 648
TYR A 652
LEU A 692
TYR A 696
 None
 0.20A 5ki6A-4krfA:
60.0		 5ki6A-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.21A 5ki6A-4krfA:
60.0		 5ki6A-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 5 ARG A 686
CYH A 689
GLN A 697
PRO A 698
ILE A 700
 None
 0.27A 5ki6A-4krfA:
60.0		 5ki6A-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 ALA A 688
LEU A 648
ILE A 649
GLY A 614
ILE A 685
 None
 1.07A 5m24A-4krfA:
undetectable		 5m24A-4krfA:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
THR A 655
 None
 0.18A 5t7bA-4krfA:
60.3		 5t7bA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 7 LEU A 648
TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.32A 5t7bA-4krfA:
60.3		 5t7bA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 7 GLN A 430
GLY A 431
GLN A 580
ASP A 434
 None
 1.05A 5vlmE-4krfA:
undetectable		 5vlmE-4krfA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_2
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 ASP A 667
PRO A 670
GLU A 671
TYR A 764
 None
 1.34A 5xprA-4krfA:
0.0		 5xprA-4krfA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 5 PRO A 324
VAL A 282
GLY A 193
VAL A 228
 None
 1.10A 6ak3B-4krfA:
undetectable		 6ak3B-4krfA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 9 ARG A 165
ALA A 159
VAL A 157
SER A 156
ASP A 161
 None
 1.44A 6c2mA-4krfA:
undetectable		 6c2mA-4krfA:
7.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 VAL A 589
ALA A 618
PHE A 651
PHE A 657
 None
 0.18A 6cbdA-4krfA:
61.6		 6cbdA-4krfA:
82.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		6 / 6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.36A 6cbdA-4krfA:
61.6		 6cbdA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		4 / 4 MET A 540
GLY A 539
HIS A 847
GLY A 534
 None
 1.41A 6fgdA-4krfA:
5.2		 6fgdA-4krfA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4krf PROTEIN ARGONAUTE-1
(Homo
sapiens) 		5 / 12 VAL A 279
THR A 173
VAL A 228
GLU A 266
CYH A 342
 None
 1.32A 6gngB-4krfA:
2.0		 6gngB-4krfA:
20.50