SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.99A 1d4sA-4krgA:
undetectable		 1d4sA-4krgA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 1.01A 1d4yA-4krgA:
undetectable		 1d4yA-4krgA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 6 GLY A  61
ASP A  80
TYR A 127
SER A  84
 SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-4.9A)
None
 0.93A 1eswA-4krgA:
undetectable		 1eswA-4krgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  47
LEU A  69
ILE A  58
THR A 230
ILE A 150
 None
 1.30A 1i18A-4krgA:
undetectable
1i18B-4krgA:
undetectable		 1i18A-4krgA:
11.31
1i18B-4krgA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 THR A 230
ILE A 150
LEU A  47
LEU A  69
ILE A  58
 None
 1.28A 1i18A-4krgA:
undetectable
1i18B-4krgA:
undetectable		 1i18A-4krgA:
11.31
1i18B-4krgA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 4 HIS A 108
ASP A  80
SER A  84
ASP A 105
 None
SAH  A 502 (-2.5A)
None
SAH  A 502 (-3.0A)
 1.36A 1n2xA-4krgA:
14.1		 1n2xA-4krgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ILE A  58
GLY A  59
GLY A  61
THR A  79
ASN A 122
 None
SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
None
SAH  A 502 (-3.9A)
 0.74A 1nv8A-4krgA:
11.2		 1nv8A-4krgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ASP A  57
GLY A  59
LEU A 128
PHE A 120
ASN A 122
 None
SAH  A 502 (-3.6A)
None
None
SAH  A 502 (-3.9A)
 1.26A 1nw3A-4krgA:
11.7		 1nw3A-4krgA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  69
ASP A  57
ALA A  60
ASP A  80
VAL A  68
 None
None
None
SAH  A 502 (-2.5A)
None
 0.93A 1t3rA-4krgA:
undetectable		 1t3rA-4krgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		3 / 3 GLY A  59
ASP A  80
ASN A 122
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.9A)
 0.46A 1vq1A-4krgA:
10.7		 1vq1A-4krgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 5 TYR A 101
SER A  78
THR A  66
ASN A  93
 None
 1.47A 1yvpA-4krgA:
undetectable		 1yvpA-4krgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 6 TRP A 123
TYR A 127
PHE A 120
ARG A  64
 OPE  A 501 ( 3.8A)
SAH  A 502 (-4.9A)
None
SAH  A 502 (-3.9A)
 1.39A 2a3cA-4krgA:
undetectable		 2a3cA-4krgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.91A 2avvE-4krgA:
undetectable		 2avvE-4krgA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.93A 2o4kA-4krgA:
undetectable		 2o4kA-4krgA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ASP A  57
ALA A  60
ASP A  80
ILE A  62
VAL A  68
 None
None
SAH  A 502 (-2.5A)
None
None
 1.13A 2o4lA-4krgA:
undetectable		 2o4lA-4krgA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.93A 2o4lA-4krgA:
undetectable		 2o4lA-4krgA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 11 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.95A 2o4pA-4krgA:
undetectable		 2o4pA-4krgA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A 144
LEU A 138
MET A 125
LEU A 189
LEU A 152
 None
 1.45A 2oaxA-4krgA:
undetectable		 2oaxA-4krgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 VAL A  68
ALA A  73
LEU A 118
SER A  45
THR A  72
 None
 1.23A 2oipC-4krgA:
2.0		 2oipC-4krgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 7 TYR A 127
LEU A  28
ASN A  29
TYR A 180
 SAH  A 502 (-4.9A)
OPE  A 501 ( 4.1A)
None
OPE  A 501 (-4.5A)
 1.37A 2w98A-4krgA:
6.9
2w98B-4krgA:
6.8		 2w98A-4krgA:
22.29
2w98B-4krgA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ARG A 298
GLU A 323
SER A 308
VAL A 319
VAL A 294
 None
 1.31A 3bjmA-4krgA:
2.6		 3bjmA-4krgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ARG A 298
GLU A 323
SER A 308
VAL A 319
VAL A 294
 None
 1.33A 3bjmB-4krgA:
undetectable		 3bjmB-4krgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 TRP A  14
GLY A  59
PHE A  81
ASP A 105
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 0.85A 3iv6A-4krgA:
17.0		 3iv6A-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		6 / 12 TRP A  14
GLY A  59
ASP A  80
PHE A  81
ASP A 105
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 0.75A 3iv6B-4krgA:
17.2		 3iv6B-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 TRP A  14
GLY A  61
ASP A  80
PHE A  81
ASP A 105
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
 1.32A 3iv6B-4krgA:
17.2		 3iv6B-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		6 / 12 TRP A  14
GLY A  59
PHE A  81
ASP A 105
ARG A 153
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
None
 0.90A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 TRP A  14
GLY A  61
PHE A  81
ASP A 105
ARG A 153
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 1.24A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		6 / 12 TRP A  14
GLY A  59
PHE A  81
ASP A 105
ARG A 153
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
None
 0.83A 3iv6D-4krgA:
17.3		 3iv6D-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		3 / 3 ASN A 122
ASP A  39
ARG A 163
 SAH  A 502 (-3.9A)
None
None
 0.91A 3k13C-4krgA:
undetectable		 3k13C-4krgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		6 / 12 GLY A  59
GLY A  61
PHE A  81
ASP A 105
ARG A   7
TYR A 127
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
SAH  A 502 (-3.6A)
SAH  A 502 (-4.9A)
 1.26A 3o7wA-4krgA:
10.0		 3o7wA-4krgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  86
 None
None
None
SAH  A 502 (-2.5A)
None
 0.95A 3ogqA-4krgA:
undetectable		 3ogqA-4krgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 5 LEU A 229
ARG A 362
LEU A  47
PRO A  48
 None
 1.17A 3onnA-4krgA:
undetectable		 3onnA-4krgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.93A 3oxwC-4krgA:
undetectable		 3oxwC-4krgA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.90A 3oxxC-4krgA:
undetectable		 3oxxC-4krgA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		6 / 11 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
VAL A  68
 None
None
None
SAH  A 502 (-2.5A)
None
None
 1.05A 3oxxD-4krgA:
undetectable		 3oxxD-4krgA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 LEU A  44
LEU A  47
VAL A  76
ASP A  57
VAL A  55
 None
 1.25A 4c9nB-4krgA:
undetectable		 4c9nB-4krgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 11 ASP A  57
GLY A  59
GLY A  61
ASP A  80
ASN A 122
 None
SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.9A)
 0.79A 4dcmA-4krgA:
13.7		 4dcmA-4krgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ILE A  99
GLU A  36
GLY A  63
GLY A  61
 None
None
None
None
SAH  A 502 (-3.4A)
 1.25A 4hfpB-4krgA:
undetectable		 4hfpB-4krgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 GLY A  59
GLY A  61
ASP A  80
ASP A 105
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.0A)
None
 0.40A 4iv8A-4krgA:
16.4		 4iv8A-4krgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 GLY A  59
GLY A  61
ASP A  80
ASP A 105
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.0A)
None
 0.42A 4iv8B-4krgA:
16.5		 4iv8B-4krgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		3 / 3 SER A  25
MET A 169
ASP A  39
 None
 0.90A 4mm4B-4krgA:
undetectable		 4mm4B-4krgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.96A 4njuA-4krgA:
undetectable		 4njuA-4krgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.95A 4njuC-4krgA:
undetectable		 4njuC-4krgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 10 ALA A  60
VAL A  76
LEU A  50
LEU A 118
PHE A 120
 None
 1.29A 4zmeB-4krgA:
undetectable		 4zmeB-4krgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 4 ASP A  57
GLY A  61
ASP A  80
ASP A 105
 None
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.0A)
 0.74A 5e72A-4krgA:
13.7		 5e72A-4krgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 11 ILE A 389
VAL A 322
VAL A 294
MET A 369
LEU A 352
 None
 1.35A 5jkwA-4krgA:
undetectable		 5jkwA-4krgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 GLY A  59
GLY A  61
ASP A  80
LEU A 124
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
None
None
 0.53A 5wy0A-4krgA:
10.1		 5wy0A-4krgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 GLY A  59
ASP A  80
ASP A 105
ALA A 106
LEU A 124
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.0A)
SAH  A 502 (-3.4A)
None
 0.79A 6bq4A-4krgA:
10.8		 6bq4A-4krgA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 GLY A  59
ASP A  80
ASP A 105
ALA A 106
LEU A 124
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.0A)
SAH  A 502 (-3.4A)
None
 0.79A 6bq4B-4krgA:
10.8		 6bq4B-4krgA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		4 / 8 TYR A 293
THR A 296
CYH A 378
LEU A 374
 None
 1.36A 6cnjD-4krgA:
undetectable
6cnjE-4krgA:
undetectable		 6cnjD-4krgA:
12.25
6cnjE-4krgA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  62
 None
None
None
SAH  A 502 (-2.5A)
None
 0.94A 6dilA-4krgA:
undetectable		 6dilA-4krgA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Haemonchus
contortus) 		5 / 12 ASP A  57
GLY A  59
GLY A  61
ASP A 105
PHE A 120
 None
SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.0A)
None
 0.63A 6nj9K-4krgA:
9.8		 6nj9K-4krgA:
22.55