SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 11 GLY A 234
ASP A 268
VAL A 263
GLY A 248
VAL A 258
 None
 0.87A 1hxwB-4kriA:
undetectable		 1hxwB-4kriA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.75A 1kiaA-4kriA:
16.0		 1kiaA-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.75A 1kiaD-4kriA:
16.6		 1kiaD-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 PHE A 195
TYR A 325
PRO A 202
 None
1SH  A 702 (-4.2A)
None
 1.15A 1mcnA-4kriA:
undetectable
1mcnB-4kriA:
undetectable
1mcnP-4kriA:
undetectable		 1mcnA-4kriA:
15.94
1mcnB-4kriA:
15.94
1mcnP-4kriA:
0.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.67A 1nbhA-4kriA:
16.4		 1nbhA-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.67A 1nbhB-4kriA:
18.5		 1nbhB-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.67A 1nbhC-4kriA:
18.3		 1nbhC-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.68A 1nbhD-4kriA:
17.9		 1nbhD-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.88A 1nbiC-4kriA:
undetectable		 1nbiC-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.87A 1nbiD-4kriA:
undetectable		 1nbiD-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 8 PHE A 362
PHE A 307
ALA A 427
ILE A 365
 None
 1.09A 1pnlA-4kriA:
undetectable
1pnlB-4kriA:
undetectable		 1pnlA-4kriA:
20.46
1pnlB-4kriA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 7 PHE A 155
PHE A 136
MET A 113
MET A 110
 None
 1.02A 1wrlE-4kriA:
undetectable		 1wrlE-4kriA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 ILE A 200
GLY A 230
LEU A 251
ASP A 277
ILE A 300
 SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.5A)
 0.94A 1zq9A-4kriA:
12.9		 1zq9A-4kriA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 ILE A 227
GLY A 228
GLY A 230
LEU A 251
HIS A 299
 None
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.2A)
 0.63A 2fk8A-4kriA:
26.4		 2fk8A-4kriA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
ASP A 250
ALA A 278
ARG A 294
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.7A)
None
SAH  A 701 (-4.2A)
 0.69A 2gluA-4kriA:
19.5		 2gluA-4kriA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
ASP A 250
ALA A 278
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.7A)
SAH  A 701 (-4.2A)
 0.57A 2gluA-4kriA:
19.5		 2gluA-4kriA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
ALA A 278
ARG A 294
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.7A)
None
SAH  A 701 (-4.2A)
 0.62A 2gluB-4kriA:
19.2		 2gluB-4kriA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 234
ASP A 268
VAL A 263
GLY A 248
VAL A 258
 None
 0.93A 2q5kB-4kriA:
undetectable		 2q5kB-4kriA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 5 ILE A 363
PHE A 425
VAL A 249
PHE A 215
 None
 1.27A 2ygnA-4kriA:
undetectable		 2ygnA-4kriA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 6 LEU A 412
GLN A 413
LEU A 378
PHE A 374
 None
 1.01A 2zxwP-4kriA:
undetectable
2zxwW-4kriA:
undetectable		 2zxwP-4kriA:
21.21
2zxwW-4kriA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 6 LEU A 412
GLN A 413
LEU A 378
PHE A 374
 None
 0.94A 3ag1C-4kriA:
undetectable
3ag1J-4kriA:
undetectable		 3ag1C-4kriA:
21.21
3ag1J-4kriA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 LEU A 350
VAL A 327
GLY A 328
ASP A 418
THR A 371
 None
 1.22A 3bf1A-4kriA:
undetectable
3bf1B-4kriA:
undetectable		 3bf1A-4kriA:
21.35
3bf1B-4kriA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 GLY A 230
ASP A 250
SER A 252
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-4.7A)
 0.70A 3brfA-4kriA:
undetectable		 3brfA-4kriA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
SER A 252
ASP A 277
ARG A 294
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
None
 0.81A 3dlcA-4kriA:
18.0		 3dlcA-4kriA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
CYH A 296
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
 0.77A 3e23A-4kriA:
19.7		 3e23A-4kriA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
ASP A 277
ALA A 278
ILE A 300
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.7A)
SAH  A 701 (-4.5A)
 0.53A 3fuuA-4kriA:
12.7		 3fuuA-4kriA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 11 GLY A 228
GLY A 230
ASP A 277
ALA A 278
ILE A 300
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.7A)
SAH  A 701 (-4.5A)
 0.73A 3grvA-4kriA:
13.5		 3grvA-4kriA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 GLU A 266
GLU A 192
ASN A 198
 None
 0.79A 3lp9B-4kriA:
undetectable
3lp9D-4kriA:
undetectable		 3lp9B-4kriA:
19.22
3lp9D-4kriA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 GLY A 230
ASP A 250
ASP A 277
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.26A 3ou7C-4kriA:
17.0		 3ou7C-4kriA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		7 / 12 TYR A 183
GLY A 230
LEU A 251
SER A 252
MET A 255
ASP A 277
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
 0.62A 3pfgA-4kriA:
16.1		 3pfgA-4kriA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
SER A 252
MET A 255
PHE A 195
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
None
 1.29A 3pfgA-4kriA:
16.1		 3pfgA-4kriA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 LYS A  17
VAL A  15
HIS A  14
 None
 1.21A 3tj7A-4kriA:
undetectable		 3tj7A-4kriA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 LEU A 178
GLY A 230
ILE A 188
ARG A 294
ASP A 295
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
None
None
None
SAH  A 701 (-4.2A)
 1.28A 3uj6A-4kriA:
38.6		 3uj6A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		7 / 12 LEU A 178
TYR A 183
ILE A 200
GLY A 228
ARG A 294
ASP A 295
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-4.2A)
 0.81A 3uj6A-4kriA:
38.6		 3uj6A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 LEU A 178
TYR A 183
GLY A 228
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.62A 3uj7A-4kriA:
38.4		 3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 LEU A 178
TYR A 183
ILE A 200
GLY A 228
ASP A 295
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.62A 3uj7A-4kriA:
38.4		 3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 LEU A 178
GLY A 228
GLY A 230
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.54A 3uj7B-4kriA:
38.7		 3uj7B-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 LEU A 178
ILE A 200
GLY A 228
GLY A 230
ASP A 295
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.66A 3uj7B-4kriA:
38.7		 3uj7B-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 LEU A 314
GLY A 361
ILE A 310
ASP A 364
ALA A 427
 None
 0.86A 3uj7B-4kriA:
38.7		 3uj7B-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 5 TYR A 183
SER A 201
ASP A 250
ASP A 277
 SAH  A 701 ( 4.2A)
SAH  A 701 (-2.7A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.42A 3uj7B-4kriA:
38.7		 3uj7B-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 232
GLY A 234
ASP A 250
ASP A 277
 SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 1.03A 4b17A-4kriA:
11.6		 4b17A-4kriA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 LEU A 178
ASP A 226
GLY A 230
GLY A 233
LEU A 251
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.6A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.4A)
 0.79A 4blvA-4kriA:
10.2		 4blvA-4kriA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 7 GLU A 338
TYR A 339
GLY A 407
LYS A 411
 None
1SH  A 702 (-4.6A)
None
1SH  A 702 (-2.6A)
 1.08A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 7 TYR A 339
ARG A 343
GLY A 407
LYS A 411
 1SH  A 702 (-4.6A)
1SH  A 702 (-4.0A)
None
1SH  A 702 (-2.6A)
 0.58A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 8 TYR A 339
ARG A 343
GLY A 407
LYS A 411
 1SH  A 702 (-4.6A)
1SH  A 702 (-4.0A)
None
1SH  A 702 (-2.6A)
 0.60A 4fgzA-4kriA:
38.6
4fgzB-4kriA:
38.5		 4fgzA-4kriA:
23.80
4fgzB-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 232
GLY A 233
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.47A 4fp9D-4kriA:
11.3		 4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 232
GLY A 234
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.97A 4fp9D-4kriA:
11.3		 4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 232
GLY A 233
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.36A 4fzvA-4kriA:
11.2		 4fzvA-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 232
GLY A 234
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.90A 4fzvA-4kriA:
11.2		 4fzvA-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
LEU A 251
SER A 252
ALA A 278
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.7A)
 0.64A 4htfA-4kriA:
17.5		 4htfA-4kriA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
LEU A 251
SER A 252
ALA A 278
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.7A)
 0.60A 4htfB-4kriA:
16.8		 4htfB-4kriA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 TYR A 183
ILE A 200
GLY A 228
GLY A 230
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.71A 4iv0A-4kriA:
38.1		 4iv0A-4kriA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 4 SER A 201
ASP A 250
MET A 255
ASP A 277
 SAH  A 701 (-2.7A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
 0.79A 4iv0A-4kriA:
38.1		 4iv0A-4kriA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
MET A 255
ILE A 227
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.9A)
None
SAH  A 701 (-4.2A)
 1.05A 4iv0B-4kriA:
36.7		 4iv0B-4kriA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		8 / 12 TYR A 183
ILE A 200
GLY A 228
GLY A 230
MET A 255
ASP A 277
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
None
SAH  A 701 (-4.2A)
 0.81A 4iv0B-4kriA:
36.7		 4iv0B-4kriA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 GLY A 228
GLY A 230
ASP A 250
ASP A 277
ARG A 294
LEU A 306
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
None
None
 1.26A 4iv8A-4kriA:
33.3		 4iv8A-4kriA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		7 / 12 GLY A 228
GLY A 230
ASP A 250
MET A 255
ASP A 277
ARG A 294
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
None
SAH  A 701 (-4.2A)
 0.69A 4iv8A-4kriA:
33.3		 4iv8A-4kriA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 GLY A 228
GLY A 230
ASP A 250
ASP A 277
ARG A 294
LEU A 306
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
None
None
 1.22A 4iv8B-4kriA:
33.2		 4iv8B-4kriA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		7 / 12 GLY A 228
GLY A 230
ASP A 250
MET A 255
ASP A 277
ARG A 294
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
None
SAH  A 701 (-4.2A)
 0.73A 4iv8B-4kriA:
33.2		 4iv8B-4kriA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		12 / 12 PHE A 174
TYR A 183
GLY A 228
GLY A 230
LEU A 251
SER A 252
ASP A 277
ALA A 278
ARG A 294
CYH A 296
HIS A 299
ILE A 300
 SAH  A 701 ( 4.8A)
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.7A)
None
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
SAH  A 701 (-4.5A)
 0.24A 4krhA-4kriA:
63.5		 4krhA-4kriA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		12 / 12 PHE A 174
TYR A 183
PHE A 199
GLY A 228
GLY A 230
LEU A 251
SER A 252
ALA A 278
ARG A 294
CYH A 296
HIS A 299
ILE A 300
 SAH  A 701 ( 4.8A)
SAH  A 701 ( 4.2A)
None
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.7A)
None
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
SAH  A 701 (-4.5A)
 0.19A 4krhB-4kriA:
64.4		 4krhB-4kriA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 4 ILE A 200
SER A 201
ASP A 250
ASP A 277
 SAH  A 701 ( 4.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.14A 4krhB-4kriA:
64.4		 4krhB-4kriA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 230
MET A 255
ILE A 227
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.9A)
None
SAH  A 701 (-4.2A)
 1.05A 4mwzA-4kriA:
36.3		 4mwzA-4kriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		7 / 12 TYR A 183
ILE A 200
GLY A 228
GLY A 230
MET A 255
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.9A)
None
SAH  A 701 (-4.2A)
 0.84A 4mwzA-4kriA:
36.3		 4mwzA-4kriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 SER A 201
ASP A 250
ASP A 277
 SAH  A 701 (-2.7A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.52A 4mwzA-4kriA:
36.3		 4mwzA-4kriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 TYR A 183
ILE A 200
GLY A 228
GLY A 230
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.69A 4mwzB-4kriA:
38.2		 4mwzB-4kriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 4 SER A 201
ASP A 250
MET A 255
ASP A 277
 SAH  A 701 (-2.7A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
 0.78A 4mwzB-4kriA:
38.2		 4mwzB-4kriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.71A 4qdjA-4kriA:
18.8		 4qdjA-4kriA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 TYR A 183
GLY A 228
GLY A 230
SER A 252
MET A 255
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
 0.68A 4qtuB-4kriA:
19.2		 4qtuB-4kriA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 GLY A 228
GLY A 230
GLY A 232
ASN A 198
LEU A 251
ALA A 278
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-3.7A)
 1.45A 4uciA-4kriA:
7.1		 4uciA-4kriA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 GLY A 228
GLY A 230
GLY A 232
ASN A 198
LEU A 251
ALA A 278
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-3.7A)
 1.45A 4uciB-4kriA:
7.1		 4uciB-4kriA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		6 / 12 GLY A 228
GLY A 230
GLY A 232
ASN A 198
LEU A 251
ALA A 278
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-3.7A)
 1.48A 4uckA-4kriA:
7.0		 4uckA-4kriA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 4 ASP A 226
GLY A 230
ASP A 250
ASP A 277
 SAH  A 701 ( 4.6A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.52A 5e72A-4kriA:
14.6		 5e72A-4kriA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 TYR A 345
TYR A 191
GLN A 182
 1SH  A 702 (-4.8A)
1SH  A 702 (-4.1A)
1SH  A 702 (-4.0A)
 0.92A 5jsdA-4kriA:
undetectable
5jsdB-4kriA:
undetectable		 5jsdA-4kriA:
20.78
5jsdB-4kriA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 TYR A 345
TYR A 191
GLN A 182
 1SH  A 702 (-4.8A)
1SH  A 702 (-4.1A)
1SH  A 702 (-4.0A)
 0.92A 5jsdB-4kriA:
undetectable
5jsdC-4kriA:
undetectable		 5jsdB-4kriA:
20.78
5jsdC-4kriA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 SER A 201
GLY A 228
GLY A 230
SER A 252
ASP A 277
 SAH  A 701 (-2.7A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.86A 5kpcB-4kriA:
22.6		 5kpcB-4kriA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 5 HIS A  13
ILE A  16
PHE A  41
ALA A  64
 None
 1.23A 5msdA-4kriA:
3.0		 5msdA-4kriA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 8 ASN A 254
LEU A 104
LEU A 260
ALA A 257
 None
 0.78A 5y7pE-4kriA:
undetectable		 5y7pE-4kriA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 234
ASP A 250
LEU A 251
ASP A 277
 SAH  A 701 (-3.5A)
None
SAH  A 701 (-2.7A)
SAH  A 701 (-4.4A)
SAH  A 701 (-3.4A)
 0.63A 5yniA-4kriA:
8.4		 5yniA-4kriA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 GLY A 228
GLY A 234
ASP A 250
LEU A 251
ASP A 277
 SAH  A 701 (-3.5A)
None
SAH  A 701 (-2.7A)
SAH  A 701 (-4.4A)
SAH  A 701 (-3.4A)
 0.67A 5ynmA-4kriA:
8.5		 5ynmA-4kriA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		5 / 12 ASP A 226
GLY A 228
GLY A 230
ASP A 277
PHE A 292
 SAH  A 701 ( 4.6A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
None
 0.69A 6nj9K-4kriA:
8.5		 6nj9K-4kriA:
22.54