SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		4 / 7 ASP B  62
VAL B  64
GLY B  50
ILE B  51
 None
 0.76A 1t7iB-4krmB:
undetectable		 1t7iB-4krmB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		4 / 8 ASP B  62
VAL B  64
GLY B  50
ILE B  51
 None
 0.76A 3nu9A-4krmB:
undetectable		 3nu9A-4krmB:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		6 / 12 ALA B  24
MET B  34
ARG B  72
ASN B  77
VAL B  79
ALA B  98
 None
 0.82A 3qxtA-4krmB:
23.3		 3qxtA-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 12 SER B  29
MET B  34
ARG B  72
VAL B  79
ALA B  98
 None
 0.47A 3qxtA-4krmB:
23.3		 3qxtA-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		7 / 12 LEU B   4
ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
 None
 0.58A 3qxtB-4krmB:
23.6		 3qxtB-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		7 / 12 LEU B   4
SER B  29
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
 None
 0.91A 3qxtB-4krmB:
23.6		 3qxtB-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		6 / 12 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 113
 None
 0.43A 3qxvA-4krmB:
23.5		 3qxvA-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 12 ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 113
 None
 0.71A 3qxvB-4krmB:
23.4		 3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 12 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
 None
 0.38A 3qxvB-4krmB:
23.4		 3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 12 SER B  29
MET B  34
VAL B  79
ALA B  98
TYR B 113
 None
 0.92A 3qxvB-4krmB:
23.4		 3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 11 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
 None
 0.70A 3qxvC-4krmB:
23.8		 3qxvC-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 11 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
 None
 0.34A 3qxvC-4krmB:
23.8		 3qxvC-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		6 / 12 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
 None
 0.71A 3qxvD-4krmB:
23.3		 3qxvD-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		5 / 12 SER B  29
MET B  34
VAL B  79
ALA B  98
TYR B 113
 None
 0.98A 3qxvD-4krmB:
23.3		 3qxvD-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		6 / 12 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
 None
 0.76A 3qxvE-4krmB:
19.7		 3qxvE-4krmB:
70.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		4 / 7 ALA B  92
THR B  91
VAL B 120
GLU B  89
 None
 0.72A 5ecmD-4krmB:
undetectable		 5ecmD-4krmB:
12.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4krm NANOBODY/VHH DOMAIN
7D12
(Lama
glama) 		3 / 3 TYR B  60
GLY B  66
THR B  69
 None
 0.17A 6cjkB-4krmB:
19.5		 6cjkB-4krmB:
31.03