SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4krp CETUXIMAB LIGHT
CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU C 135
THR C 172
SER C 162
THR C 164
 None
 0.67A 1ictD-4krpC:
undetectable		 1ictD-4krpC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4krp CETUXIMAB LIGHT
CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU C 104
GLU C  17
VAL C  13
LEU C  47
LEU C  73
 None
 1.35A 1mrqA-4krpC:
undetectable		 1mrqA-4krpC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4krp CETUXIMAB LIGHT
CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU C 179
VAL C 132
PHE C 209
VAL C 150
 None
 1.14A 3soaA-4krpC:
undetectable		 3soaA-4krpC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4krp CETUXIMAB LIGHT
CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 ARG C  39
PHE C  62
PRO C  59
LEU C  47
 None
 1.35A 3tgvD-4krpC:
undetectable		 3tgvD-4krpC:
23.94