SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4krt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		4 / 8 TRP A 313
ASP A 312
ILE A 324
THR A 325
 None
None
None
ACT  A 405 ( 4.7A)
 0.81A 1hmyA-4krtA:
undetectable		 1hmyA-4krtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		4 / 8 LEU A 221
VAL A 258
TYR A 256
GLY A 265
 None
None
ACT  A 404 ( 4.6A)
None
 0.92A 1jlbA-4krtA:
undetectable		 1jlbA-4krtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		3 / 3 TRP A 255
TYR A 256
LEU A 221
 None
ACT  A 404 ( 4.6A)
None
 1.03A 1kxhA-4krtA:
2.1		 1kxhA-4krtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		4 / 7 LEU A 221
VAL A 258
TYR A 256
GLY A 265
 None
None
ACT  A 404 ( 4.6A)
None
 0.93A 1lweA-4krtA:
undetectable		 1lweA-4krtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 GLU A  88
ASN A  87
ILE A  83
ALA A  79
VAL A 124
 None
 1.35A 2drdA-4krtA:
undetectable		 2drdA-4krtA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
EPE  A 401 (-3.3A)
None
None
 1.48A 3fhjD-4krtA:
2.1		 3fhjD-4krtA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
EPE  A 401 (-3.3A)
None
None
 1.48A 3fhjF-4krtA:
undetectable		 3fhjF-4krtA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		4 / 5 LYS A 130
VAL A  63
ILE A 202
TYR A 152
 None
 1.48A 3gvuA-4krtA:
undetectable		 3gvuA-4krtA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 ARG A  70
ILE A 102
ALA A  71
LEU A 145
VAL A 108
 None
 1.49A 3o01A-4krtA:
undetectable
3o01B-4krtA:
undetectable		 3o01A-4krtA:
21.70
3o01B-4krtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 ILE A 102
ALA A  71
LEU A 145
ASN A 144
VAL A 108
 None
 1.43A 3o01A-4krtA:
undetectable
3o01B-4krtA:
undetectable		 3o01A-4krtA:
21.70
3o01B-4krtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 12 CYH A 117
LEU A 121
THR A 138
ALA A 141
ILE A 169
 None
 1.11A 4o2bB-4krtA:
undetectable		 4o2bB-4krtA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 12 CYH A 117
LEU A 121
THR A 138
ALA A 141
ILE A 169
 None
 1.14A 4x1iD-4krtA:
undetectable		 4x1iD-4krtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 12 CYH A 117
LEU A 121
THR A 138
ALA A 141
ILE A 169
 None
 1.09A 4x1yB-4krtA:
undetectable		 4x1yB-4krtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		4 / 7 LEU A 100
THR A 136
THR A 114
LEU A 113
 None
 0.96A 4z91F-4krtA:
undetectable
4z91G-4krtA:
undetectable
4z91H-4krtA:
undetectable
4z91I-4krtA:
undetectable
4z91J-4krtA:
undetectable		 4z91F-4krtA:
21.24
4z91G-4krtA:
21.24
4z91H-4krtA:
21.24
4z91I-4krtA:
21.24
4z91J-4krtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
 None
 1.49A 5eifA-4krtA:
undetectable		 5eifA-4krtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		3 / 3 CYH A 191
MET A 193
ASN A 194
 None
 1.10A 5qh8A-4krtA:
undetectable		 5qh8A-4krtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
EPE  A 401 (-3.3A)
None
None
 1.43A 5v0iA-4krtA:
undetectable		 5v0iA-4krtA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4krt AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101) 		5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
EPE  A 401 (-3.3A)
None
None
 1.46A 5v0iB-4krtA:
undetectable		 5v0iB-4krtA:
20.72