SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 GLU A  88
ASN A  87
ILE A  83
ALA A  79
VAL A 124
None
1.33A 2drdA-4kruA:
undetectable
2drdA-4kruA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.41A 2pxcA-4kruA:
undetectable
2pxcA-4kruA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 10 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.36A 3fhjA-4kruA:
undetectable
3fhjA-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 10 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.37A 3fhjB-4kruA:
undetectable
3fhjB-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 10 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.36A 3fhjC-4kruA:
undetectable
3fhjC-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.37A 3fhjD-4kruA:
2.0
3fhjD-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 10 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.36A 3fhjE-4kruA:
undetectable
3fhjE-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.37A 3fhjF-4kruA:
undetectable
3fhjF-4kruA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 5 LYS A 130
VAL A  63
ILE A 202
TYR A 152
None
1.29A 3gvuA-4kruA:
undetectable
3gvuA-4kruA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 8 ASP A  77
PHE A 120
LEU A  86
ASP A  84
None
1.02A 3m0wE-4kruA:
undetectable
3m0wF-4kruA:
undetectable
3m0wG-4kruA:
undetectable
3m0wH-4kruA:
undetectable
3m0wE-4kruA:
18.94
3m0wF-4kruA:
18.94
3m0wG-4kruA:
18.94
3m0wH-4kruA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 11 VAL A 124
VAL A 133
TYR A  66
LEU A  86
TYR A  94
None
None
NDG  A 501 (-3.9A)
None
None
1.29A 3m8pA-4kruA:
undetectable
3m8pB-4kruA:
1.7
3m8pA-4kruA:
17.22
3m8pB-4kruA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 8 GLU A 106
TYR A 137
ARG A  70
PHE A  68
None
1.08A 3mjrD-4kruA:
undetectable
3mjrD-4kruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 ILE A 102
ASN A  72
LEU A 145
ASN A 144
VAL A 108
None
1.40A 3o01A-4kruA:
undetectable
3o01B-4kruA:
undetectable
3o01A-4kruA:
21.12
3o01B-4kruA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.39A 3p97A-4kruA:
undetectable
3p97A-4kruA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.47A 3p97C-4kruA:
undetectable
3p97C-4kruA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.40A 4ctjA-4kruA:
undetectable
4ctjA-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.39A 4ctkA-4kruA:
undetectable
4ctkA-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 7 LEU A 100
THR A 136
THR A 114
LEU A 113
None
0.92A 4z91F-4kruA:
undetectable
4z91G-4kruA:
undetectable
4z91H-4kruA:
undetectable
4z91I-4kruA:
undetectable
4z91J-4kruA:
undetectable
4z91F-4kruA:
20.71
4z91G-4kruA:
20.71
4z91H-4kruA:
20.71
4z91I-4kruA:
20.71
4z91J-4kruA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.41A 5e9qA-4kruA:
undetectable
5e9qA-4kruA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.50A 5e9qC-4kruA:
undetectable
5e9qC-4kruA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.45A 5ec8C-4kruA:
undetectable
5ec8C-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.44A 5ec8C-4kruA:
undetectable
5ec8C-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.41A 5eifA-4kruA:
undetectable
5eifA-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.41A 5eifA-4kruA:
undetectable
5eifA-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.49A 5eifC-4kruA:
undetectable
5eifC-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.41A 5eiwC-4kruA:
undetectable
5eiwC-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
TRP A 155
ASP A  29
VAL A  31
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.38A 5eiwC-4kruA:
undetectable
5eiwC-4kruA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
6 / 12 GLY A  11
GLY A 175
TRP A 155
ASP A  29
ASP A  13
ILE A  12
None
None
None
None
NDG  A 501 (-3.6A)
None
1.47A 5kqsA-4kruA:
undetectable
5kqsA-4kruA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
3 / 3 CYH A 191
MET A 193
ASN A 194
None
1.10A 5qh8A-4kruA:
undetectable
5qh8A-4kruA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.32A 5v0iA-4kruA:
undetectable
5v0iA-4kruA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 9 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
None
None
NDG  A 501 (-4.0A)
None
None
1.35A 5v0iB-4kruA:
undetectable
5v0iB-4kruA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 7 GLY A 189
TRP A  17
ASP A  13
MET A 193
None
None
NDG  A 501 (-3.6A)
None
1.36A 6ag0A-4kruA:
5.6
6ag0A-4kruA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 7 GLY A 189
TRP A  17
ASP A  13
MET A 193
None
None
NDG  A 501 (-3.6A)
None
1.39A 6ag0C-4kruA:
6.7
6ag0C-4kruA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
4 / 7 ASN A   6
ASN A   8
GLU A 195
ARG A   4
None
1.28A 6b8kA-4kruA:
undetectable
6b8kA-4kruA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
4kru AUTOLYTIC LYSOZYME
(Clostridium
phage
phiSM101)
5 / 10 VAL A 124
VAL A 133
TYR A  66
LEU A  86
TYR A  94
None
None
NDG  A 501 (-3.9A)
None
None
1.39A 6bsiA-4kruA:
undetectable
6bsiA-4kruA:
16.57