SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ks8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.99A 1fm6A-4ks8A:
undetectable		 1fm6A-4ks8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.90A 1icrA-4ks8A:
undetectable
1icrB-4ks8A:
undetectable		 1icrA-4ks8A:
25.00
1icrB-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 GLU A 593
GLY A 597
SER A 529
THR A 490
 None
 0.90A 1icrA-4ks8A:
undetectable
1icrB-4ks8A:
undetectable		 1icrA-4ks8A:
25.00
1icrB-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.93A 1icuA-4ks8A:
undetectable
1icuB-4ks8A:
undetectable		 1icuA-4ks8A:
25.00
1icuB-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 GLU A 593
GLY A 597
SER A 529
THR A 490
 None
 0.93A 1icuA-4ks8A:
undetectable
1icuB-4ks8A:
undetectable		 1icuA-4ks8A:
25.00
1icuB-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.93A 1icuC-4ks8A:
undetectable
1icuD-4ks8A:
undetectable		 1icuC-4ks8A:
25.00
1icuD-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.91A 1icvC-4ks8A:
undetectable
1icvD-4ks8A:
undetectable		 1icvC-4ks8A:
25.00
1icvD-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 GLU A 593
GLY A 597
SER A 529
THR A 490
 None
 0.95A 1icvC-4ks8A:
undetectable
1icvD-4ks8A:
undetectable		 1icvC-4ks8A:
25.00
1icvD-4ks8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.91A 1kqbA-4ks8A:
undetectable
1kqbB-4ks8A:
undetectable		 1kqbA-4ks8A:
24.25
1kqbB-4ks8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 GLU A 593
GLY A 597
SER A 529
THR A 490
 None
 0.93A 1kqbA-4ks8A:
undetectable
1kqbB-4ks8A:
undetectable		 1kqbA-4ks8A:
24.25
1kqbB-4ks8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 SER A 529
THR A 490
GLU A 593
GLY A 597
 None
 0.88A 1kqbC-4ks8A:
undetectable
1kqbD-4ks8A:
undetectable		 1kqbC-4ks8A:
24.25
1kqbD-4ks8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 GLU A 593
GLY A 597
SER A 529
THR A 490
 None
 0.89A 1kqbC-4ks8A:
undetectable
1kqbD-4ks8A:
undetectable		 1kqbC-4ks8A:
24.25
1kqbD-4ks8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 9 VAL A 421
ALA A 434
MET A 481
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
B49  A 701 (-3.4A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.43A 1xbbA-4ks8A:
26.1		 1xbbA-4ks8A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 1.03A 1xdkA-4ks8A:
undetectable		 1xdkA-4ks8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 1.03A 1xdkE-4ks8A:
undetectable		 1xdkE-4ks8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.95A 1xiuA-4ks8A:
undetectable		 1xiuA-4ks8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ALA A 434
LYS A 436
MET A 456
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.59A 2gqgA-4ks8A:
26.5		 2gqgA-4ks8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 ALA A 434
LYS A 436
MET A 456
GLY A 487
ASP A 491
LEU A 533
 B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.68A 2itoA-4ks8A:
25.1		 2itoA-4ks8A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 GLY A 414
VAL A 421
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
ASP A 544
 B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.74A 2ityA-4ks8A:
25.1		 2ityA-4ks8A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 VAL A 421
ALA A 434
LYS A 436
MET A 456
GLY A 487
ASP A 491
LEU A 533
ASP A 544
 None
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.75A 2itzA-4ks8A:
25.5		 2itzA-4ks8A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 542
ALA A 513
LEU A 587
PHE A 462
 None
 1.33A 2oaxB-4ks8A:
undetectable		 2oaxB-4ks8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 542
ALA A 513
LEU A 587
PHE A 462
 None
 1.28A 2oaxD-4ks8A:
undetectable		 2oaxD-4ks8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 542
ALA A 513
LEU A 587
PHE A 462
 None
 1.28A 2oaxE-4ks8A:
undetectable		 2oaxE-4ks8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 542
ALA A 513
LEU A 587
PHE A 462
 None
 1.23A 2oaxF-4ks8A:
undetectable		 2oaxF-4ks8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 ILE A 413
VAL A 421
ALA A 434
GLY A 487
LEU A 533
ASP A 544
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.51A 2y7jA-4ks8A:
22.1		 2y7jA-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 10 ILE A 413
VAL A 421
ALA A 434
GLY A 487
LEU A 533
ASP A 544
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.46A 2y7jB-4ks8A:
30.9		 2y7jB-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 10 ILE A 413
VAL A 421
ALA A 434
GLY A 487
ASP A 491
LEU A 533
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.57A 2y7jC-4ks8A:
30.8		 2y7jC-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 10 ILE A 413
VAL A 421
ALA A 434
GLY A 487
ASP A 491
LEU A 533
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.45A 2y7jD-4ks8A:
30.6		 2y7jD-4ks8A:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 GLY A 414
ALA A 434
LYS A 436
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 ( 4.3A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.73A 3c7qA-4ks8A:
22.2		 3c7qA-4ks8A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.96A 3dzyA-4ks8A:
undetectable		 3dzyA-4ks8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 GLY A 414
GLY A 416
GLY A 419
VAL A 421
ALA A 434
LYS A 436
MET A 481
LEU A 533
 B49  A 701 ( 4.3A)
None
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.4A)
B49  A 701 (-4.5A)
 0.60A 3eygA-4ks8A:
26.7		 3eygA-4ks8A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 GLY A 414
GLY A 416
GLY A 419
VAL A 421
ALA A 434
LYS A 436
MET A 481
LEU A 533
 B49  A 701 ( 4.3A)
None
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.4A)
B49  A 701 (-4.5A)
 0.65A 3fupA-4ks8A:
26.7		 3fupA-4ks8A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 GLY A 414
ALA A 434
LYS A 436
VAL A 465
MET A 481
LEU A 484
LEU A 533
 B49  A 701 ( 4.3A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.5A)
 0.54A 3fupB-4ks8A:
26.6		 3fupB-4ks8A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 11 ILE A 413
ALA A 434
LYS A 436
VAL A 465
PHE A 483
GLY A 487
LEU A 533
SER A 543
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.65A 3miyA-4ks8A:
24.9		 3miyA-4ks8A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 11 ILE A 413
ALA A 434
VAL A 465
PHE A 483
GLY A 487
LEU A 533
SER A 543
ASP A 544
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.73A 3miyA-4ks8A:
24.9		 3miyA-4ks8A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 9 ILE A 413
ALA A 434
LYS A 436
PHE A 483
GLY A 487
LEU A 533
SER A 543
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.63A 3miyB-4ks8A:
24.6		 3miyB-4ks8A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 ALA A 434
GLU A 452
ILE A 455
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.88A 3mssD-4ks8A:
23.1		 3mssD-4ks8A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.97A 3oapA-4ks8A:
undetectable		 3oapA-4ks8A:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 9 ILE A 413
ALA A 434
VAL A 465
PHE A 483
LEU A 533
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 (-4.5A)
 0.61A 3ti1A-4ks8A:
25.5		 3ti1A-4ks8A:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ALA A 434
LYS A 436
GLU A 452
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.61A 3ue4A-4ks8A:
26.6		 3ue4A-4ks8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 VAL A 421
ALA A 434
GLU A 452
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.64A 3ue4B-4ks8A:
26.0		 3ue4B-4ks8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 GLY A 416
GLY A 419
VAL A 421
ALA A 434
VAL A 465
LEU A 533
SER A 543
ASP A 544
 None
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.95A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 GLY A 416
VAL A 421
ALA A 434
LYS A 436
VAL A 465
LEU A 533
SER A 543
 None
None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.92A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ILE A 413
GLY A 416
GLY A 419
VAL A 421
ALA A 434
SER A 543
ASP A 544
 B49  A 701 (-4.2A)
None
None
None
B49  A 701 (-3.2A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.83A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 ILE A 413
GLY A 416
VAL A 421
ALA A 434
LYS A 436
SER A 543
 B49  A 701 (-4.2A)
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.0A)
 0.84A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 LYS A 436
ILE A 455
VAL A 465
LEU A 533
 None
None
None
B49  A 701 (-4.5A)
 0.91A 3wzdA-4ks8A:
23.1		 3wzdA-4ks8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 LYS A 436
VAL A 465
LEU A 533
ASP A 544
 None
None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.76A 3wzdA-4ks8A:
23.1		 3wzdA-4ks8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 6 THR A 535
GLY A 486
ILE A 492
LEU A 533
 None
None
None
B49  A 701 (-4.5A)
 0.95A 4acbC-4ks8A:
undetectable		 4acbC-4ks8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 VAL A 421
ALA A 434
LYS A 436
GLU A 452
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.73A 4ag8A-4ks8A:
22.8		 4ag8A-4ks8A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 VAL A 421
ALA A 434
LYS A 436
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.65A 4ag8A-4ks8A:
22.8		 4ag8A-4ks8A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 11 ALA A 434
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.43A 4agdA-4ks8A:
21.9		 4agdA-4ks8A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		8 / 12 GLY A 414
VAL A 421
ALA A 434
LYS A 436
MET A 481
GLY A 487
ASP A 491
LEU A 533
 B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.4A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.59A 4i22A-4ks8A:
23.1		 4i22A-4ks8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 GLU A 571
SER A 576
ARG A 646
SER A 574
 None
 1.47A 4k17B-4ks8A:
undetectable		 4k17B-4ks8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 11 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.85A 4nqaA-4ks8A:
undetectable		 4nqaA-4ks8A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 11 ILE A 413
ALA A 434
LYS A 436
GLU A 452
MET A 481
LEU A 484
ASP A 544
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.6A)
 1.18A 4qmsA-4ks8A:
37.2		 4qmsA-4ks8A:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ILE A 413
GLY A 414
VAL A 421
ALA A 434
MET A 481
LEU A 484
LEU A 533
 B49  A 701 (-4.2A)
B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.5A)
 0.38A 4qmzA-4ks8A:
38.1		 4qmzA-4ks8A:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 ILE A 413
GLY A 414
VAL A 421
LEU A 484
GLY A 486
LEU A 533
 B49  A 701 (-4.2A)
B49  A 701 ( 4.3A)
None
B49  A 701 (-4.4A)
None
B49  A 701 (-4.5A)
 0.97A 4qmzA-4ks8A:
38.1		 4qmzA-4ks8A:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		4 / 5 LEU A 653
GLU A 651
MET A 638
LEU A 587
 None
 1.29A 4xi3B-4ks8A:
undetectable		 4xi3B-4ks8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 GLY A 588
MET A 638
GLU A 593
ILE A 592
ILE A 503
 None
 1.24A 4zvmA-4ks8A:
undetectable
4zvmB-4ks8A:
undetectable		 4zvmA-4ks8A:
21.12
4zvmB-4ks8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ILE A 413
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
SER A 543
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.74A 5i9yA-4ks8A:
23.8		 5i9yA-4ks8A:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 7 GLY A 414
GLY A 416
SER A 417
GLY A 419
VAL A 421
 B49  A 701 ( 4.3A)
None
None
None
None
 0.71A 5izjB-4ks8A:
28.1		 5izjB-4ks8A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 11 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.99A 5ji0A-4ks8A:
undetectable		 5ji0A-4ks8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 434
GLU A 452
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.73A 5te0A-4ks8A:
26.0		 5te0A-4ks8A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 434
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.54A 5te0A-4ks8A:
26.0		 5te0A-4ks8A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.93A 5uanA-4ks8A:
undetectable		 5uanA-4ks8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 GLU A 508
LEU A 498
LEU A 667
LEU A 534
ILE A 532
 None
 1.13A 5v0vA-4ks8A:
undetectable		 5v0vA-4ks8A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 PRO A 565
THR A 564
TRP A 567
THR A 490
SER A 531
 None
 1.28A 5xiqC-4ks8A:
undetectable		 5xiqC-4ks8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		6 / 12 GLY A 414
VAL A 421
ALA A 434
ASP A 491
LEU A 533
ASP A 544
 B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.72A 5yu9B-4ks8A:
23.2		 5yu9B-4ks8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 VAL A 421
ALA A 434
GLY A 487
ASP A 491
ASP A 544
 None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.6A)
 0.70A 5yu9C-4ks8A:
23.0		 5yu9C-4ks8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		5 / 12 VAL A 421
ALA A 434
GLY A 487
ASP A 491
LEU A 533
 None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
 0.48A 5yu9D-4ks8A:
23.6		 5yu9D-4ks8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		3 / 3 LYS A 436
LEU A 533
ASP A 544
 None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.80A 5zv2A-4ks8A:
23.0		 5zv2A-4ks8A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens) 		7 / 12 ILE A 413
VAL A 421
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.78A 6fnmA-4ks8A:
24.4		 6fnmA-4ks8A:
32.18