SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ks9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 ILE A 252
SER A 291
ILE A 290
VAL A 256
ILE A 201
 None
 1.00A 2nnhA-4ks9A:
undetectable		 2nnhA-4ks9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		4 / 4 GLU A 255
ARG A 231
ASN A 230
ASP A 227
 None
 1.27A 2zq9A-4ks9A:
undetectable		 2zq9A-4ks9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		3 / 3 GLU A 255
VAL A 254
CYH A 238
 None
 0.99A 3fbxA-4ks9A:
undetectable		 3fbxA-4ks9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		4 / 5 LEU A 297
GLY A 296
PHE A 187
PHE A 191
 None
 1.21A 3smtA-4ks9A:
undetectable		 3smtA-4ks9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		3 / 3 GLU A 184
GLY A 299
SER A 188
 None
 0.65A 4b53B-4ks9A:
undetectable		 4b53B-4ks9A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		3 / 3 ARG A 467
TYR A 444
ASN A 454
 None
 0.95A 4ffwB-4ks9A:
undetectable		 4ffwB-4ks9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 104
ASP A 165
ALA A  94
PHE A 158
PHE A 142
 None
 1.44A 4iaqA-4ks9A:
undetectable		 4iaqA-4ks9A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 104
ASP A 165
ALA A  94
PHE A 158
PHE A 142
 None
 1.47A 4iarA-4ks9A:
undetectable		 4iarA-4ks9A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 9 TRP A 336
SER A 373
ALA A 334
LEU A 337
GLY A 368
 None
 1.49A 4l6va-4ks9A:
undetectable
4l6vf-4ks9A:
undetectable		 4l6va-4ks9A:
20.82
4l6vf-4ks9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 GLY A 400
GLY A 403
GLY A 461
ASN A 462
ALA A 406
 None
 0.97A 4uciA-4ks9A:
undetectable		 4uciA-4ks9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 GLY A 400
GLY A 403
GLY A 461
ASN A 462
ALA A 406
 None
 0.99A 4uciB-4ks9A:
undetectable		 4uciB-4ks9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 GLY A 400
GLY A 403
GLY A 461
ASN A 462
ALA A 406
 None
 0.92A 4uckA-4ks9A:
undetectable		 4uckA-4ks9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 9 TRP A 425
LEU A 375
LEU A 349
ILE A 345
ALA A 392
 None
 1.36A 4z69A-4ks9A:
undetectable		 4z69A-4ks9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 232
ARG A 237
SER A 289
TYR A 239
LEU A 210
 None
 1.18A 5czyA-4ks9A:
2.3		 5czyA-4ks9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		4 / 5 ARG A 398
THR A 390
HIS A 394
ALA A 393
 None
 1.26A 5mfxA-4ks9A:
undetectable		 5mfxA-4ks9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		3 / 3 ARG A 398
ARG A 353
ARG A 347
 None
 0.96A 6bplA-4ks9A:
2.6
6bplB-4ks9A:
undetectable		 6bplA-4ks9A:
10.51
6bplB-4ks9A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ks9 MALONYL-COA
DECARBOXYLASE
(Cupriavidus
metallidurans) 		5 / 10 TRP A 336
ARG A 338
ALA A 334
LEU A 337
GLY A 368
 None
 1.36A 6hqbA-4ks9A:
undetectable
6hqbJ-4ks9A:
undetectable		 6hqbA-4ks9A:
10.05
6hqbJ-4ks9A:
7.59