SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ksa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 5 THR A 346
GLU A 342
THR A 339
LEU A 359
 None
 1.22A 1d4fC-4ksaA:
undetectable		 1d4fC-4ksaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 7 GLU A 239
GLU A 200
ILE A 205
LEU A 254
 None
 1.27A 1q0yH-4ksaA:
undetectable
1q0yL-4ksaA:
undetectable		 1q0yH-4ksaA:
17.35
1q0yL-4ksaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.04A 1rxcC-4ksaA:
undetectable		 1rxcC-4ksaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.07A 1rxcD-4ksaA:
undetectable		 1rxcD-4ksaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.06A 1rxcF-4ksaA:
undetectable		 1rxcF-4ksaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 369
ALA A 368
GLN A 365
LEU A 449
LEU A 396
 None
 1.02A 1xiuB-4ksaA:
undetectable		 1xiuB-4ksaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 236
SER A 275
ILE A 274
VAL A 240
ILE A 184
 None
 1.01A 2nnhA-4ksaA:
undetectable		 2nnhA-4ksaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 6 LEU A 142
THR A 139
PHE A 170
LEU A 281
 None
 1.14A 2wm3A-4ksaA:
undetectable		 2wm3A-4ksaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 4 TYR A 272
LEU A 311
LEU A 253
HIS A 203
 None
 1.48A 2x7hB-4ksaA:
undetectable		 2x7hB-4ksaA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 281
GLY A 280
PHE A 170
PHE A 174
 None
 1.14A 3smtA-4ksaA:
undetectable		 3smtA-4ksaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 8 LEU A 215
ARG A 214
TYR A 223
GLU A 239
 None
 1.38A 3zmdA-4ksaA:
undetectable
3zmdB-4ksaA:
undetectable		 3zmdA-4ksaA:
18.93
3zmdB-4ksaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.02A 4e1vB-4ksaA:
undetectable		 4e1vB-4ksaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 438
ARG A 380
ILE A 440
PRO A 381
 None
 1.00A 4e1vH-4ksaA:
undetectable		 4e1vH-4ksaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		3 / 3 MET A  40
GLU A  44
LEU A  48
 None
 0.67A 4v2oB-4ksaA:
undetectable		 4v2oB-4ksaA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		3 / 4 ARG A 119
GLY A 115
GLU A 116
 None
 0.66A 4z2dB-4ksaA:
undetectable
4z2dC-4ksaA:
undetectable		 4z2dB-4ksaA:
23.98
4z2dC-4ksaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 6 ILE A 196
PHE A 237
ARG A 214
ILE A 205
 None
 1.40A 4zzcA-4ksaA:
undetectable
4zzcB-4ksaA:
undetectable		 4zzcA-4ksaA:
20.00
4zzcB-4ksaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 6 ILE A 196
PHE A 237
ARG A 214
ILE A 205
 None
 1.41A 4zzcB-4ksaA:
undetectable
4zzcC-4ksaA:
undetectable		 4zzcB-4ksaA:
20.00
4zzcC-4ksaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		3 / 3 HIS A 168
SER A 172
ARG A 130
 MG  A 501 (-3.6A)
None
None
 0.85A 5u63A-4ksaA:
undetectable		 5u63A-4ksaA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		5 / 10 TYR A 370
ALA A 367
LEU A 399
LEU A 396
VAL A 418
 None
 1.25A 6g2pB-4ksaA:
undetectable		 6g2pB-4ksaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 422
ASN A 392
PHE A 225
TYR A 223
 None
 1.20A 6huoC-4ksaA:
undetectable
6huoD-4ksaA:
undetectable		 6huoC-4ksaA:
10.18
6huoD-4ksaA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4ksa MALONYL-COA
DECARBOXYLASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 422
ASN A 392
VAL A 238
TYR A 223
 None
 1.10A 6huoC-4ksaA:
undetectable
6huoD-4ksaA:
undetectable		 6huoC-4ksaA:
10.18
6huoD-4ksaA:
11.35