SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ksf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 8 SER A  46
ALA A  57
LEU A 124
ASP A  36
 None
 1.11A 2bxkA-4ksfA:
undetectable		 2bxkA-4ksfA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		3 / 3 ARG A 397
ASP A 244
ASP A 251
 None
 0.54A 2ejtA-4ksfA:
undetectable		 2ejtA-4ksfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 12 LEU A  44
LEU A 134
LEU A 121
GLY A 130
LEU A  61
 None
 0.94A 2ouzA-4ksfA:
undetectable		 2ouzA-4ksfA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 6 ARG A  66
PHE A  67
ILE A  37
PHE A  75
 None
 1.25A 2qeiA-4ksfA:
undetectable		 2qeiA-4ksfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 7 LEU A 282
PHE A 281
PHE A 217
LEU A 173
 None
 1.07A 3asoP-4ksfA:
undetectable
3asoW-4ksfA:
undetectable		 3asoP-4ksfA:
19.47
3asoW-4ksfA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 6 THR A 235
TYR A 264
ASP A 244
THR A 260
 None
 0.95A 3q70A-4ksfA:
undetectable		 3q70A-4ksfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 10 VAL A 232
PHE A 263
GLY A 279
PHE A 380
ASN A 384
 None
 1.38A 3r6wA-4ksfA:
undetectable
3r6wB-4ksfA:
undetectable		 3r6wA-4ksfA:
21.14
3r6wB-4ksfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 11 SER A 237
ILE A 238
VAL A 262
PHE A 300
VAL A 301
 None
 1.37A 3rf4A-4ksfA:
undetectable
3rf4C-4ksfA:
undetectable		 3rf4A-4ksfA:
15.33
3rf4C-4ksfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 11 SER A 237
ILE A 238
VAL A 262
PHE A 300
VAL A 301
 None
 1.35A 3rf4A-4ksfA:
undetectable
3rf4B-4ksfA:
undetectable		 3rf4A-4ksfA:
15.33
3rf4B-4ksfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 11 SER A 237
ILE A 238
VAL A 262
PHE A 300
VAL A 301
 None
 1.33A 3rf4B-4ksfA:
undetectable
3rf4C-4ksfA:
undetectable		 3rf4B-4ksfA:
15.33
3rf4C-4ksfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 4 PRO A 357
LEU A 358
ILE A 313
ARG A 317
 None
 1.40A 3w1wA-4ksfA:
undetectable		 3w1wA-4ksfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 7 ILE A 197
VAL A 286
ILE A 266
PHE A 215
 None
 0.97A 5hieC-4ksfA:
undetectable		 5hieC-4ksfA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		4 / 5 LEU A 282
PHE A 281
PHE A 217
LEU A 173
 None
 1.07A 5x1bP-4ksfA:
undetectable		 5x1bP-4ksfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		5 / 10 TYR A 362
ALA A 359
LEU A 391
LEU A 388
VAL A 410
 None
 1.29A 6g2pB-4ksfA:
undetectable		 6g2pB-4ksfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ksf MALONYL-COA
DECARBOXYLASE
(Agrobacterium
vitis) 		3 / 3 ARG A 387
LEU A 413
PHE A 300
 None
 0.70A 6nknP-4ksfA:
undetectable		 6nknP-4ksfA:
19.47