SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 8 LEU A 370
VAL A 387
GLY A 386
LEU A 358
 None
 0.88A 1jlbA-4kssA:
undetectable		 1jlbA-4kssA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 8 LEU A 370
VAL A 387
GLY A 386
LEU A 358
 None
 0.88A 1s1xA-4kssA:
undetectable		 1s1xA-4kssA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		5 / 9 GLY A 258
SER A 348
LEU A 349
SER A 383
LEU A 379
 None
 1.49A 2j2pB-4kssA:
undetectable
2j2pC-4kssA:
undetectable		 2j2pB-4kssA:
15.91
2j2pC-4kssA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		5 / 9 VAL A 354
GLY A 258
LEU A 349
SER A 383
LEU A 379
 None
 1.45A 2j2pB-4kssA:
undetectable
2j2pC-4kssA:
undetectable		 2j2pB-4kssA:
15.91
2j2pC-4kssA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		3 / 3 SER A 525
GLU A 605
ASP A 644
 None
 0.58A 2zulA-4kssA:
2.4		 2zulA-4kssA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		3 / 3 MET A 355
GLU A 292
ASP A 298
 None
 1.03A 3a25A-4kssA:
undetectable		 3a25A-4kssA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 6 LEU A 611
GLN A 590
LEU A 636
PHE A 567
 None
 1.01A 3ag1C-4kssA:
undetectable
3ag1J-4kssA:
undetectable		 3ag1C-4kssA:
16.64
3ag1J-4kssA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		3 / 3 SER A 525
GLU A 605
ASP A 644
 None
 0.59A 3dmhA-4kssA:
2.2		 3dmhA-4kssA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 8 HIS A 459
LEU A 261
LEU A 370
SER A 381
 None
 0.96A 3lm8B-4kssA:
1.4
3lm8D-4kssA:
2.0		 3lm8B-4kssA:
17.70
3lm8D-4kssA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		3 / 3 VAL A 616
VAL A 521
SER A 574
 None
 0.74A 3n8xB-4kssA:
undetectable		 3n8xB-4kssA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		5 / 12 LEU A 227
ASP A 208
VAL A 209
SER A 199
ALA A 183
 None
 1.29A 4nc3A-4kssA:
undetectable		 4nc3A-4kssA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		5 / 12 THR A 357
LEU A 447
ILE A 253
GLY A 277
LEU A 274
 None
 1.17A 5gs4A-4kssA:
undetectable		 5gs4A-4kssA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 5 ILE A 458
LYS A 469
ILE A 471
VAL A 364
 None
 0.95A 5jmnA-4kssA:
undetectable		 5jmnA-4kssA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 5 GLU A 446
GLY A 365
ARG A 391
GLY A 264
 None
 1.14A 5kprA-4kssA:
undetectable		 5kprA-4kssA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 8 HIS A 352
VAL A 354
VAL A 330
LEU A 319
 None
 0.84A 5tt3F-4kssA:
undetectable		 5tt3F-4kssA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN
(Pseudomonas
aeruginosa;
Vibrio
cholerae) 		4 / 9 ILE A 135
ILE A 142
ILE A 153
LEU A 165
 None
 0.79A 5vkqB-4kssA:
undetectable
5vkqC-4kssA:
undetectable		 5vkqB-4kssA:
15.84
5vkqC-4kssA:
15.84