SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ksy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.95A 1c6yA-4ksyA:
undetectable		 1c6yA-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 296
LEU A 202
ALA A 262
LEU A 265
 None
 1.01A 1hwiB-4ksyA:
undetectable		 1hwiB-4ksyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 296
LEU A 202
ALA A 262
LEU A 265
 None
 1.00A 1hwiC-4ksyA:
undetectable		 1hwiC-4ksyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 299
TYR A 163
TYR A 167
LEU A 172
 None
None
1SY  A 500 (-3.9A)
None
 1.06A 3v81A-4ksyA:
undetectable		 3v81A-4ksyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 239
GLY A 230
LYS A 236
 None
 0.70A 4k50A-4ksyA:
undetectable		 4k50A-4ksyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.93A 4njtC-4ksyA:
undetectable		 4njtC-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.99A 4njuB-4ksyA:
undetectable		 4njuB-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.99A 4njuD-4ksyA:
undetectable		 4njuD-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.96A 4rvjA-4ksyA:
undetectable		 4rvjA-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 222
ASP A 223
VAL A 258
THR A 256
ILE A 244
 None
 0.96A 4rvjC-4ksyA:
undetectable		 4rvjC-4ksyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 240
LEU A 172
GLU A 260
LEU A 198
 1SY  A 500 (-4.7A)
None
1SY  A 500 (-4.2A)
None
 1.32A 5xooA-4ksyA:
undetectable		 5xooA-4ksyA:
13.15