SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		3 / 3 GLY A 382
GLU A 219
ASN A 387
 None
 0.70A 1zq9A-4kt6A:
undetectable		 1zq9A-4kt6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		4 / 7 ASP A 308
LYS A 329
GLU A 326
ASP A 332
 None
 1.33A 3bc9A-4kt6A:
undetectable		 3bc9A-4kt6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		3 / 3 ARG A 295
VAL A 280
THR A 275
 None
 0.86A 3cyxA-4kt6A:
undetectable		 3cyxA-4kt6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 402
ILE A 411
ILE A 419
ILE A 440
ILE A 420
 None
 0.98A 3uj6A-4kt6A:
undetectable		 3uj6A-4kt6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		4 / 5 HIS A 431
SER A 398
SER A 291
VAL A 399
 None
 1.41A 4a99D-4kt6A:
undetectable		 4a99D-4kt6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		4 / 5 LEU A 349
ILE A 359
ALA A 271
PHE A 394
 None
 1.08A 4dc3B-4kt6A:
undetectable		 4dc3B-4kt6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		4 / 6 GLY A 357
ASP A 430
PRO A 427
ARG A 360
 None
 1.17A 4lajA-4kt6A:
undetectable
4lajB-4kt6A:
undetectable		 4lajA-4kt6A:
20.00
4lajB-4kt6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 284
ALA A 409
LEU A 408
PHE A 305
 None
 1.02A 4rkuA-4kt6A:
undetectable
4rkuJ-4kt6A:
undetectable		 4rkuA-4kt6A:
15.95
4rkuJ-4kt6A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 399
THR A 292
ILE A 293
ARG A 289
PHE A 284
 None
 1.17A 5mxbA-4kt6A:
undetectable		 5mxbA-4kt6A:
16.87