SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ktd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4ktd GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		4 / 8 VAL L 106
ARG L  61
ALA L  19
GLU L  83
 None
None
None
GOL  L 303 (-2.7A)
 0.84A 1dmiA-4ktdL:
undetectable
1dmiB-4ktdL:
undetectable		 1dmiA-4ktdL:
21.97
1dmiB-4ktdL:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4ktd GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ARG L 103
VAL L 146
THR L 161
 None
 0.64A 2nmzA-4ktdL:
undetectable		 2nmzA-4ktdL:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 2y03A-4ktdH:
undetectable		 2y03A-4ktdH:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.47A 2y03B-4ktdH:
undetectable		 2y03B-4ktdH:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		5 / 7 VAL H  93
VAL H 102
GLY H 104
PRO L  43
ARG H  94
 None
 1.24A 3bjwC-4ktdH:
undetectable		 3bjwC-4ktdH:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		5 / 8 VAL H  93
VAL H 102
GLY H 104
PRO L  43
ARG H  94
 None
 1.22A 3bjwA-4ktdH:
undetectable		 3bjwA-4ktdH:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.49A 3huoA-4ktdH:
undetectable		 3huoA-4ktdH:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4ktd GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ARG L 103
VAL L 146
THR L 161
 None
 0.82A 3k4vD-4ktdL:
undetectable		 3k4vD-4ktdL:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ASP H  33
ASN H 100
SER H  53
 None
 0.98A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ASP H  33
ASN H 100
SER H  54
 None
 0.89A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		3 / 3 SER H  53
ASP H  33
ASN H 100
 None
 0.98A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		3 / 3 SER H  54
ASP H  33
ASN H 100
 None
 0.94A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		5 / 12 PHE H 166
VAL L 195
VAL L 144
PRO L 113
PHE L 139
 None
 1.38A 3nbrA-4ktdH:
undetectable		 3nbrA-4ktdH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4ktd GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ARG L 103
VAL L 146
THR L 161
 None
 0.77A 3ndtA-4ktdL:
undetectable		 3ndtA-4ktdL:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		4 / 7 VAL H 169
SER L 179
GLN H 171
LEU H 141
 None
 1.23A 4hxyB-4ktdH:
undetectable		 4hxyB-4ktdH:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		5 / 10 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.49A 4ldoA-4ktdH:
undetectable		 4ldoA-4ktdH:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4ktd GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		3 / 3 ALA L  89
TRP L  96
VAL L  97
 None
 0.22A 4w9nC-4ktdL:
undetectable		 4w9nC-4ktdL:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		4 / 7 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.97A 4xumA-4ktdH:
undetectable		 4xumA-4ktdH:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ktd GE136 HEAVY CHAIN
FAB
GE136 LIGHT CHAIN
FAB
(Macaca
mulatta) 		4 / 5 VAL H 107
ILE L  33
PRO L  44
THR L 102
 None
 1.24A 4ze1A-4ktdH:
undetectable		 4ze1A-4ktdH:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4ktd GE136 HEAVY CHAIN
FAB
(Macaca
mulatta) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-4ktdH:
undetectable		 6h7mB-4ktdH:
20.51