SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 ALA A 336
ALA A 361
LYS A 362
GLU A 365
 None
 0.86A 1e7cA-4ktoA:
1.8		 1e7cA-4ktoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 TYR A  92
HIS A  95
SER A  96
VAL A 100
 None
 0.75A 1jtvA-4ktoA:
undetectable		 1jtvA-4ktoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 244
TYR A 174
LEU A  98
GLN A 102
 None
 1.03A 1kt3A-4ktoA:
undetectable		 1kt3A-4ktoA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 261
GLU A  80
ARG A  22
ARG A  18
ALA A 253
 TRS  A 402 ( 3.9A)
None
None
None
None
 0.87A 1mjlA-4ktoA:
undetectable
1mjlB-4ktoA:
undetectable		 1mjlA-4ktoA:
16.52
1mjlB-4ktoA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.07A 1rs7A-4ktoA:
undetectable		 1rs7A-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.03A 1rs7B-4ktoA:
undetectable		 1rs7B-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 116
LEU A 119
ARG A  48
TRP A  47
 None
 1.21A 2hc4A-4ktoA:
undetectable		 2hc4A-4ktoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 ILE A 162
PRO A 166
VAL A  21
PHE A  42
 FAD  A 401 ( 4.4A)
None
None
None
 1.18A 2ygnA-4ktoA:
undetectable		 2ygnA-4ktoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  58
ALA A  73
ILE A  81
LEU A  17
HIS A  95
 None
 1.04A 3dzuA-4ktoA:
undetectable		 3dzuA-4ktoA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  89
GLY A 254
PHE A  24
SER A  91
GLU A  49
 None
 1.28A 3tkaA-4ktoA:
undetectable		 3tkaA-4ktoA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.10A 4d33A-4ktoA:
undetectable		 4d33A-4ktoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.09A 4d33B-4ktoA:
undetectable		 4d33B-4ktoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.07A 4d39B-4ktoA:
undetectable		 4d39B-4ktoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.05A 4fp9A-4ktoA:
undetectable		 4fp9A-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.02A 4fp9D-4ktoA:
undetectable		 4fp9D-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.00A 4fp9F-4ktoA:
undetectable		 4fp9F-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.00A 4fzvA-4ktoA:
undetectable		 4fzvA-4ktoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 323
ILE A 325
VAL A 307
SER A 252
 None
 1.02A 4kcnA-4ktoA:
undetectable		 4kcnA-4ktoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 ASN A 350
ASP A  37
ASP A 205
 None
 0.85A 4obwD-4ktoA:
undetectable		 4obwD-4ktoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 163
ALA A  94
ASN A 164
 FAD  A 401 (-4.0A)
None
None
 0.34A 5ersA-4ktoA:
undetectable		 5ersA-4ktoA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A  89
GLY A 254
PRO A 255
GLY A 257
 None
 0.67A 6ag0C-4ktoA:
undetectable		 6ag0C-4ktoA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4kto ISOVALERYL-COA
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 SER A 252
ARG A 301
ALA A 300
ALA A 260
 None
 1.10A 6ma6A-4ktoA:
undetectable		 6ma6A-4ktoA:
15.85