SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ktp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 5 LEU A  84
GLU A  89
ALA A 155
LEU A 157
 None
 1.08A 1eta2-4ktpA:
undetectable		 1eta2-4ktpA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ILE A 586
TYR A 611
VAL A 591
ILE A 544
ASN A 610
 None
 1.23A 1fm4A-4ktpA:
undetectable		 1fm4A-4ktpA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 9 GLY A  30
ILE A 307
GLY A  41
ILE A  58
ILE A 670
 None
 1.03A 1hpvA-4ktpA:
undetectable		 1hpvA-4ktpA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 6 HIS A 697
LEU A 689
LEU A 698
PRO A 700
 None
 1.17A 1hz4A-4ktpA:
3.1		 1hz4A-4ktpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.88A 1muiB-4ktpA:
undetectable		 1muiB-4ktpA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 ASN A 301
ALA A 305
ASN A 339
 None
 0.63A 1n4fA-4ktpA:
undetectable		 1n4fA-4ktpA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 6 TYR A 643
ASP A 294
ASN A 291
GLU A 763
 None
 1.15A 1rjdC-4ktpA:
undetectable		 1rjdC-4ktpA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 SER A  31
ARG A  43
ASN A  32
ASP A 653
 None
 1.36A 1rs6A-4ktpA:
undetectable		 1rs6A-4ktpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.77A 1sduB-4ktpA:
undetectable		 1sduB-4ktpA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 ASP A 590
PHE A 595
ASN A 487
 None
 0.85A 1sg9B-4ktpA:
undetectable		 1sg9B-4ktpA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.93A 1sguB-4ktpA:
undetectable		 1sguB-4ktpA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.21A 1v55C-4ktpA:
3.3
1v55N-4ktpA:
undetectable
1v55P-4ktpA:
3.3		 1v55C-4ktpA:
14.87
1v55N-4ktpA:
19.54
1v55P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 ASN A 169
TRP A  70
GLN A 325
 None
 1.30A 1xoqA-4ktpA:
undetectable		 1xoqA-4ktpA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 PHE A 332
GLY A 318
GLY A 321
LEU A  73
SER A  74
 BGC  A 801 (-3.7A)
None
None
None
None
 0.97A 1ya4A-4ktpA:
undetectable		 1ya4A-4ktpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 GLU A 475
GLN A 413
TYR A 378
GLU A 389
 BGC  A 801 (-3.3A)
None
None
None
 1.36A 2aowA-4ktpA:
undetectable		 2aowA-4ktpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2avvA-4ktpA:
undetectable		 2avvA-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.83A 2b7zA-4ktpA:
undetectable		 2b7zA-4ktpA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 PHE A  46
ASP A  49
ALA A  26
ARG A 102
 None
 1.17A 2e5dA-4ktpA:
undetectable
2e5dB-4ktpA:
undetectable		 2e5dA-4ktpA:
21.01
2e5dB-4ktpA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 PHE A  46
ASP A  49
ALA A  26
ARG A 102
 None
 1.18A 2e5dA-4ktpA:
undetectable
2e5dB-4ktpA:
undetectable		 2e5dA-4ktpA:
21.01
2e5dB-4ktpA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.79A 2hs1A-4ktpA:
undetectable		 2hs1A-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.90A 2hs1B-4ktpA:
undetectable		 2hs1B-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ILE A 516
GLU A 522
LEU A 501
ARG A 450
ALA A 453
 None
 1.27A 2jj8C-4ktpA:
undetectable		 2jj8C-4ktpA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ILE A 670
GLY A 669
GLY A 668
ILE A 667
ILE A 652
 None
 0.93A 2o4kA-4ktpA:
undetectable		 2o4kA-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.82A 2pymB-4ktpA:
undetectable		 2pymB-4ktpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2pynB-4ktpA:
undetectable		 2pynB-4ktpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2q63B-4ktpA:
undetectable		 2q63B-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2qakB-4ktpA:
undetectable		 2qakB-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.77A 2r5pD-4ktpA:
undetectable		 2r5pD-4ktpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 6 ARG A 644
ILE A 592
GLN A 593
TYR A 338
 None
 1.40A 2ya7C-4ktpA:
undetectable		 2ya7C-4ktpA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.17A 3ablC-4ktpA:
3.4
3ablN-4ktpA:
1.4
3ablP-4ktpA:
3.3		 3ablC-4ktpA:
14.87
3ablN-4ktpA:
19.54
3ablP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 LEU A 494
PHE A 492
HIS A 488
LEU A 601
TYR A 602
 None
 1.36A 3adsA-4ktpA:
undetectable		 3adsA-4ktpA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.87A 3d1zA-4ktpA:
undetectable		 3d1zA-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 5 TYR A 629
ALA A 642
TYR A 643
MET A 681
 None
 1.05A 3d91A-4ktpA:
undetectable		 3d91A-4ktpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 6 ILE A 586
TYR A 573
LYS A 560
ILE A 556
 None
 1.12A 3eteA-4ktpA:
undetectable
3eteE-4ktpA:
undetectable		 3eteA-4ktpA:
21.72
3eteE-4ktpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 LYS A 560
ILE A 556
ILE A 586
TYR A 573
 None
 1.13A 3eteD-4ktpA:
undetectable
3eteF-4ktpA:
undetectable		 3eteD-4ktpA:
21.72
3eteF-4ktpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 SER A 383
LEU A 355
PHE A 451
GLU A 336
ASP A 419
 None
 1.39A 3ko0A-4ktpA:
undetectable
3ko0B-4ktpA:
undetectable
3ko0C-4ktpA:
undetectable
3ko0D-4ktpA:
undetectable		 3ko0A-4ktpA:
7.74
3ko0B-4ktpA:
7.74
3ko0C-4ktpA:
7.74
3ko0D-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 GLU A 336
ASP A 419
LEU A 355
PHE A 451
SER A 383
 None
 1.39A 3ko0C-4ktpA:
undetectable
3ko0D-4ktpA:
undetectable
3ko0E-4ktpA:
undetectable
3ko0F-4ktpA:
undetectable		 3ko0C-4ktpA:
7.74
3ko0D-4ktpA:
7.74
3ko0E-4ktpA:
7.74
3ko0F-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 GLU A 336
ASP A 419
LEU A 355
PHE A 451
SER A 383
 None
 1.43A 3ko0E-4ktpA:
undetectable
3ko0F-4ktpA:
undetectable
3ko0G-4ktpA:
undetectable
3ko0H-4ktpA:
undetectable		 3ko0E-4ktpA:
7.74
3ko0F-4ktpA:
7.74
3ko0G-4ktpA:
7.74
3ko0H-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 GLU A 336
ASP A 419
LEU A 355
PHE A 451
SER A 383
 None
 1.41A 3ko0G-4ktpA:
undetectable
3ko0H-4ktpA:
undetectable
3ko0I-4ktpA:
undetectable
3ko0J-4ktpA:
undetectable		 3ko0G-4ktpA:
7.74
3ko0H-4ktpA:
7.74
3ko0I-4ktpA:
7.74
3ko0J-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 LEU A 355
PHE A 451
GLU A 336
ASP A 419
SER A 383
 None
 1.41A 3ko0O-4ktpA:
undetectable
3ko0P-4ktpA:
undetectable
3ko0Q-4ktpA:
undetectable
3ko0R-4ktpA:
undetectable		 3ko0O-4ktpA:
7.74
3ko0P-4ktpA:
7.74
3ko0Q-4ktpA:
7.74
3ko0R-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 SER A 383
LEU A 355
PHE A 451
GLU A 336
ASP A 419
 None
 1.44A 3ko0O-4ktpA:
undetectable
3ko0P-4ktpA:
undetectable
3ko0Q-4ktpA:
undetectable
3ko0R-4ktpA:
undetectable		 3ko0O-4ktpA:
7.74
3ko0P-4ktpA:
7.74
3ko0Q-4ktpA:
7.74
3ko0R-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 SER A 383
GLU A 336
ASP A 419
LEU A 355
PHE A 451
 None
 1.41A 3ko0Q-4ktpA:
undetectable
3ko0R-4ktpA:
undetectable
3ko0S-4ktpA:
undetectable
3ko0T-4ktpA:
undetectable		 3ko0Q-4ktpA:
7.74
3ko0R-4ktpA:
7.74
3ko0S-4ktpA:
7.74
3ko0T-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 GLU A 101
LYS A  18
ASN A  19
ILE A  16
 None
 1.25A 3kp6A-4ktpA:
undetectable
3kp6B-4ktpA:
undetectable		 3kp6A-4ktpA:
11.55
3kp6B-4ktpA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.93A 3nu3A-4ktpA:
undetectable		 3nu3A-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 HIS A   7
ARG A  20
GLU A  22
 None
 1.17A 3qf1A-4ktpA:
undetectable		 3qf1A-4ktpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 358
GLY A 318
GLN A 335
SER A 323
ALA A 319
 None
None
None
None
BGC  A 801 ( 3.7A)
 1.28A 3t7sA-4ktpA:
undetectable		 3t7sA-4ktpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 358
GLY A 318
GLN A 335
SER A 323
ALA A 319
 None
None
None
None
BGC  A 801 ( 3.7A)
 1.33A 3t7sB-4ktpA:
undetectable		 3t7sB-4ktpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 358
GLY A 318
GLN A 335
SER A 323
ALA A 319
 None
None
None
None
BGC  A 801 ( 3.7A)
 1.28A 3t7sC-4ktpA:
undetectable		 3t7sC-4ktpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.22A 3wg7C-4ktpA:
undetectable
3wg7N-4ktpA:
2.2
3wg7P-4ktpA:
undetectable		 3wg7C-4ktpA:
14.87
3wg7N-4ktpA:
19.54
3wg7P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.20A 3x2qC-4ktpA:
3.4
3x2qN-4ktpA:
2.1
3x2qP-4ktpA:
3.3		 3x2qC-4ktpA:
14.87
3x2qN-4ktpA:
19.54
3x2qP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 VAL A 430
PRO A 348
TYR A 345
ILE A 437
VAL A 424
 None
 1.30A 4eb6B-4ktpA:
2.1
4eb6C-4ktpA:
undetectable		 4eb6B-4ktpA:
20.39
4eb6C-4ktpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 ARG A 320
HIS A 671
TYR A 327
 BGC  A 801 ( 4.3A)
None
BGC  A 801 (-4.5A)
 0.75A 4fu8A-4ktpA:
undetectable		 4fu8A-4ktpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 ARG A 320
HIS A 671
TYR A 327
 BGC  A 801 ( 4.3A)
None
BGC  A 801 (-4.5A)
 0.65A 4fu9A-4ktpA:
undetectable		 4fu9A-4ktpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 4 VAL A 110
THR A 111
GLU A 130
GLU A 129
 None
 1.10A 4l78A-4ktpA:
undetectable		 4l78A-4ktpA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 GLU A 640
VAL A 724
THR A 725
ARG A 761
 None
 1.13A 4lnwA-4ktpA:
undetectable		 4lnwA-4ktpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 6 GLU A 640
VAL A 724
THR A 725
ARG A 761
 None
 1.11A 4lnxA-4ktpA:
undetectable		 4lnxA-4ktpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ALA A 633
ILE A 631
GLY A 685
ARG A 644
ASN A 645
 None
 1.20A 4obwD-4ktpA:
undetectable		 4obwD-4ktpA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 GLU A 268
GLU A 267
TYR A 266
GLU A 269
 None
 1.28A 4r87I-4ktpA:
undetectable		 4r87I-4ktpA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 LEU A 257
ALA A 260
THR A 159
ALA A  79
ILE A 161
 None
 1.16A 4x1yB-4ktpA:
undetectable		 4x1yB-4ktpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 LEU A  84
LEU A 157
LEU A 227
THR A 153
LEU A 229
 None
 0.97A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 LEU A  84
LEU A 157
LEU A 227
THR A 153
LEU A 229
 None
 1.01A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 LEU A 157
LEU A 227
THR A 153
LEU A 229
LEU A  84
 None
 0.94A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 THR A 153
LEU A 229
LEU A  84
LEU A 157
LEU A 227
 None
 1.03A 4z91A-4ktpA:
2.8
4z91B-4ktpA:
2.8
4z91C-4ktpA:
2.2
4z91D-4ktpA:
2.7
4z91E-4ktpA:
2.9		 4z91A-4ktpA:
18.19
4z91B-4ktpA:
18.19
4z91C-4ktpA:
18.19
4z91D-4ktpA:
18.19
4z91E-4ktpA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 GLY A 160
SER A 221
GLY A 220
ALA A  79
 None
 0.79A 5e26A-4ktpA:
undetectable
5e26B-4ktpA:
undetectable		 5e26A-4ktpA:
18.25
5e26B-4ktpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 ALA A  79
GLY A 160
SER A 221
GLY A 220
 None
 0.79A 5e26A-4ktpA:
undetectable
5e26B-4ktpA:
undetectable		 5e26A-4ktpA:
18.25
5e26B-4ktpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 GLY A 160
SER A 221
GLY A 220
ALA A  79
 None
 0.81A 5e26C-4ktpA:
undetectable
5e26D-4ktpA:
undetectable		 5e26C-4ktpA:
18.25
5e26D-4ktpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 ALA A  79
GLY A 160
SER A 221
GLY A 220
 None
 0.81A 5e26C-4ktpA:
undetectable
5e26D-4ktpA:
undetectable		 5e26C-4ktpA:
18.25
5e26D-4ktpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 SER A 245
HIS A 139
HIS A 312
PHE A  39
LEU A 315
 None
 1.50A 5eenB-4ktpA:
undetectable		 5eenB-4ktpA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 SER A 245
HIS A 139
HIS A 312
PHE A  39
LEU A 315
 None
 1.50A 5ef8B-4ktpA:
undetectable		 5ef8B-4ktpA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.15A 5iy5C-4ktpA:
3.3
5iy5N-4ktpA:
undetectable
5iy5P-4ktpA:
3.4		 5iy5C-4ktpA:
14.85
5iy5N-4ktpA:
19.54
5iy5P-4ktpA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 ILE A 448
LEU A 452
ALA A 453
VAL A 424
LEU A 362
 None
 1.21A 5ji0A-4ktpA:
undetectable		 5ji0A-4ktpA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 TRP A  14
THR A  12
TRP A 281
LEU A 106
 None
 1.39A 5kxiA-4ktpA:
2.6
5kxiB-4ktpA:
2.6		 5kxiA-4ktpA:
19.23
5kxiB-4ktpA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 TRP A  14
THR A  12
TRP A 281
LEU A 106
 None
 1.35A 5kxiD-4ktpA:
undetectable
5kxiE-4ktpA:
2.4		 5kxiD-4ktpA:
19.23
5kxiE-4ktpA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 PHE A 666
THR A  45
ILE A  27
GLY A  30
 None
 0.93A 5nzxA-4ktpA:
undetectable		 5nzxA-4ktpA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 PHE A 666
THR A  45
ILE A  27
GLY A  30
 None
 0.96A 5nzyA-4ktpA:
undetectable		 5nzyA-4ktpA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.19A 5w97C-4ktpA:
3.3
5w97a-4ktpA:
undetectable
5w97c-4ktpA:
3.3		 5w97C-4ktpA:
14.87
5w97a-4ktpA:
19.54
5w97c-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 11 GLY A 329
GLN A 325
THR A  62
ARG A  43
GLY A  41
 None
 1.40A 5x19A-4ktpA:
1.3
5x19B-4ktpA:
undetectable
5x19T-4ktpA:
undetectable		 5x19A-4ktpA:
19.54
5x19B-4ktpA:
14.83
5x19T-4ktpA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 ASP A 570
TYR A 572
HIS A 671
LEU A 566
 None
 1.17A 5x19A-4ktpA:
undetectable
5x19C-4ktpA:
3.3
5x19P-4ktpA:
undetectable		 5x19A-4ktpA:
19.54
5x19C-4ktpA:
14.87
5x19P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 ASP A 570
TYR A 572
HIS A 671
LEU A 566
 None
 1.16A 5x1fA-4ktpA:
undetectable
5x1fC-4ktpA:
3.4
5x1fP-4ktpA:
undetectable		 5x1fA-4ktpA:
19.54
5x1fC-4ktpA:
14.87
5x1fP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.19A 5xdqC-4ktpA:
3.4
5xdqN-4ktpA:
undetectable
5xdqP-4ktpA:
3.4		 5xdqC-4ktpA:
14.87
5xdqN-4ktpA:
19.54
5xdqP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.17A 5xdxC-4ktpA:
undetectable
5xdxN-4ktpA:
undetectable
5xdxP-4ktpA:
3.3		 5xdxC-4ktpA:
14.87
5xdxN-4ktpA:
19.54
5xdxP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 THR A 503
GLU A 499
HIS A 428
 None
 0.67A 5xioA-4ktpA:
undetectable		 5xioA-4ktpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 THR A 503
GLU A 499
HIS A 428
 None
 0.65A 5xiqB-4ktpA:
undetectable		 5xiqB-4ktpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 THR A 503
GLU A 499
HIS A 428
 None
 0.70A 5xiqD-4ktpA:
undetectable		 5xiqD-4ktpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.18A 5z84C-4ktpA:
3.3
5z84N-4ktpA:
undetectable
5z84P-4ktpA:
3.3		 5z84C-4ktpA:
14.87
5z84N-4ktpA:
19.54
5z84P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.22A 5z85C-4ktpA:
3.4
5z85N-4ktpA:
undetectable
5z85P-4ktpA:
3.4		 5z85C-4ktpA:
14.87
5z85N-4ktpA:
19.54
5z85P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 ASP A 570
TYR A 572
HIS A 671
LEU A 566
 None
 1.22A 5z86A-4ktpA:
2.3
5z86C-4ktpA:
3.4
5z86P-4ktpA:
3.4		 5z86A-4ktpA:
19.54
5z86C-4ktpA:
14.87
5z86P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.21A 5z86C-4ktpA:
3.4
5z86N-4ktpA:
undetectable
5z86P-4ktpA:
3.4		 5z86C-4ktpA:
14.87
5z86N-4ktpA:
19.54
5z86P-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 8 LEU A 566
ASP A 570
TYR A 572
HIS A 671
 None
 1.22A 5zcpC-4ktpA:
3.3
5zcpN-4ktpA:
undetectable
5zcpP-4ktpA:
3.3		 5zcpC-4ktpA:
14.87
5zcpN-4ktpA:
19.54
5zcpP-4ktpA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		3 / 3 SER A 323
SER A  31
ALA A 660
 None
 0.71A 6dwnC-4ktpA:
undetectable		 6dwnC-4ktpA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 SER A 625
ARG A 617
ILE A 557
ALA A 559
 None
 1.00A 6ma7A-4ktpA:
undetectable		 6ma7A-4ktpA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 10 ASP A 481
ASN A 483
THR A 486
HIS A 455
ASP A 411
 None
 1.41A 6mb7A-4ktpA:
undetectable		 6mb7A-4ktpA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		4 / 7 GLY A 708
TYR A 709
HIS A 764
GLY A 687
 None
 0.98A 6n7fA-4ktpA:
2.0		 6n7fA-4ktpA:
7.79