SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ku4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		4 / 4 VAL A 140
ALA A 182
LEU A  31
PHE A 183
 None
 1.26A 1q97B-4ku4A:
undetectable		 1q97B-4ku4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		3 / 3 LEU A 136
LEU A  17
MET A  16
 None
 0.76A 2itzA-4ku4A:
undetectable		 2itzA-4ku4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 12 VAL A 169
SER A 172
LEU A  27
VAL A 140
THR A 154
 None
GDP  A 301 (-3.2A)
None
None
None
 1.49A 4kyaD-4ku4A:
undetectable		 4kyaD-4ku4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 12 VAL A 169
SER A 172
LEU A  27
VAL A 140
THR A 154
 None
GDP  A 301 (-3.2A)
None
None
None
 1.48A 4kyaF-4ku4A:
undetectable		 4kyaF-4ku4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 9 ASN A 142
VAL A 140
GLY A  23
THR A  28
VAL A  87
 GDP  A 301 (-3.2A)
None
GDP  A 301 (-3.1A)
None
None
 1.26A 4r20B-4ku4A:
undetectable		 4r20B-4ku4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		4 / 8 GLU A 170
GLY A 176
THR A  25
PHE A  90
 None
None
MG  A 302 ( 3.2A)
None
 0.97A 5flcB-4ku4A:
undetectable		 5flcB-4ku4A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		4 / 8 GLU A 170
GLY A 176
THR A  25
PHE A  90
 None
None
MG  A 302 ( 3.2A)
None
 0.97A 5flcF-4ku4A:
undetectable		 5flcF-4ku4A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 12 PHE A 183
VAL A 138
ILE A  63
LEU A  27
VAL A  89
 None
 1.26A 5im2A-4ku4A:
undetectable		 5im2A-4ku4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 10 VAL A 140
GLY A 141
GLU A 170
ALA A 182
LEU A  27
 None
 1.06A 5x6yB-4ku4A:
undetectable		 5x6yB-4ku4A:
14.40