SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kuj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 PHE A 125
ALA A 110
LEU A 123
ILE A 258
ALA A 192
 None
 0.99A 1ha2A-4kujA:
undetectable		 1ha2A-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 THR A 239
GLU A  98
HIS A 228
 None
 0.88A 1xwfC-4kujA:
undetectable		 1xwfC-4kujA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 ILE A  46
PHE A 234
LEU A 226
LEU A 205
LEU A  40
 None
 1.23A 2bxfA-4kujA:
undetectable		 2bxfA-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 5 ARG A  69
LEU A 126
ARG A 102
ILE A 210
 None
 1.24A 3ln1D-4kujA:
undetectable		 3ln1D-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 SER A 247
ILE A 246
TRP A 198
GLU A 269
 None
 1.27A 4cx7A-4kujA:
undetectable
4cx7B-4kujA:
undetectable		 4cx7A-4kujA:
20.97
4cx7B-4kujA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 SER A 247
ILE A 246
TRP A 198
GLU A 269
 None
 1.17A 4cx7C-4kujA:
undetectable
4cx7D-4kujA:
undetectable		 4cx7C-4kujA:
20.97
4cx7D-4kujA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 GLY A  66
LEU A 126
GLU A 164
PHE A 171
THR A 222
 PEG  A 302 (-4.7A)
None
PEG  A 302 (-4.3A)
None
None
 1.03A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 GLY A  67
LEU A 126
GLU A 164
PHE A 171
THR A 222
 None
None
PEG  A 302 (-4.3A)
None
None
 1.12A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		7 / 11 GLY A  67
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 1.23A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		9 / 11 PHE A  63
ALA A  64
GLY A  66
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
PEG  A 302 ( 3.9A)
PEG  A 302 (-4.7A)
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 0.79A 4zmeA-4kujA:
22.9		 4zmeA-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 10 LYS A  85
LEU A 126
GLU A 164
PHE A 171
THR A 222
 PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 1.06A 4zmeB-4kujA:
22.8		 4zmeB-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		8 / 10 PHE A  63
ALA A  64
VAL A  83
LYS A  85
LEU A 126
GLU A 164
LEU A 167
THR A 222
 None
PEG  A 302 ( 3.9A)
None
PEG  A 302 (-3.2A)
None
PEG  A 302 (-4.3A)
None
None
 0.81A 4zmeB-4kujA:
22.8		 4zmeB-4kujA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ASP A 138
SER A 134
TYR A  25
 None
 0.81A 5glmA-4kujA:
undetectable		 5glmA-4kujA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 5 PHE A 250
THR A 252
ASP A 176
ASN A 240
 None
 1.13A 5ybbA-4kujA:
undetectable		 5ybbA-4kujA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4kuj PROTEIN KINASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 PHE A  51
ALA A 154
THR A  94
LEU A 146
ILE A  46
 None
 1.14A 6aybA-4kujA:
undetectable		 6aybA-4kujA:
19.31