SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 TRP A 159
VAL A 260
TRP A 341
 None
None
MAL  A 501 (-3.7A)
 1.30A 1c4dA-4kv3A:
undetectable
1c4dB-4kv3A:
undetectable		 1c4dA-4kv3A:
2.05
1c4dB-4kv3A:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.15A 2f16H-4kv3A:
undetectable
2f16I-4kv3A:
undetectable		 2f16H-4kv3A:
19.14
2f16I-4kv3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.14A 2f16V-4kv3A:
undetectable
2f16W-4kv3A:
undetectable		 2f16V-4kv3A:
19.14
2f16W-4kv3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.04A 2h42C-4kv3A:
undetectable		 2h42C-4kv3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 ASP A 198
THR A 194
LYS A 201
ASP A 359
 None
 1.27A 2j2pE-4kv3A:
undetectable
2j2pF-4kv3A:
undetectable		 2j2pE-4kv3A:
17.77
2j2pF-4kv3A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 ASP A 387
THR A 414
PRO A 415
 None
 0.67A 2q64B-4kv3A:
undetectable		 2q64B-4kv3A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 8 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-3.0A)
 1.04A 2zw9A-4kv3A:
undetectable		 2zw9A-4kv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
 1.22A 3a35A-4kv3A:
undetectable		 3a35A-4kv3A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 ALA A 189
LEU A 193
ALA A 347
THR A 346
 None
 0.88A 3b6hA-4kv3A:
undetectable		 3b6hA-4kv3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 ALA A 189
LEU A 193
ALA A 347
THR A 346
 None
 0.92A 3b6hB-4kv3A:
undetectable		 3b6hB-4kv3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 PHE A 259
ALA A 163
LEU A 248
PRO A 160
 None
 0.98A 3bgdA-4kv3A:
undetectable		 3bgdA-4kv3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.71A 3bjwC-4kv3A:
undetectable		 3bjwC-4kv3A:
12.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		11 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
TRP A 231
TYR A 342
 MAL  A 501 (-2.9A)
MAL  A 501 (-2.6A)
None
None
None
MAL  A 501 (-3.2A)
MAL  A 501 (-2.7A)
MAL  A 501 (-4.0A)
MAL  A 501 (-3.0A)
MAL  A 501 ( 4.7A)
None
 0.66A 3jyrA-4kv3A:
61.6		 3jyrA-4kv3A:
74.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		11 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
GLU A 112
PRO A 155
TRP A 231
TYR A 342
 MAL  A 501 (-2.9A)
MAL  A 501 (-2.6A)
None
None
None
MAL  A 501 (-3.2A)
MAL  A 501 (-2.7A)
MAL  A 501 (-3.0A)
MAL  A 501 (-3.6A)
MAL  A 501 ( 4.7A)
None
 0.47A 3jyrA-4kv3A:
61.6		 3jyrA-4kv3A:
74.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 MAL  A 501 (-4.4A)
MAL  A 501 (-4.5A)
MAL  A 501 (-3.6A)
MAL  A 501 (-3.9A)
MAL  A 501 ( 4.3A)
MAL  A 501 (-3.7A)
 0.23A 3jyrA-4kv3A:
61.6		 3jyrA-4kv3A:
74.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.01A 3n8yB-4kv3A:
undetectable		 3n8yB-4kv3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 9 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.21A 3sj4X-4kv3A:
undetectable		 3sj4X-4kv3A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.0A)
None
 0.83A 3tbgB-4kv3A:
undetectable		 3tbgB-4kv3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.0A)
None
 0.81A 3tbgD-4kv3A:
undetectable		 3tbgD-4kv3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 GLY A  57
TRP A  11
ASP A  56
THR A  54
 None
 1.23A 3vqrA-4kv3A:
undetectable		 3vqrA-4kv3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 3vwrA-4kv3A:
undetectable		 3vwrA-4kv3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4kv3A:
undetectable		 4or0B-4kv3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.40A 5w4zA-4kv3A:
undetectable		 5w4zA-4kv3A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.43A 5w4zB-4kv3A:
undetectable		 5w4zB-4kv3A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MAL  A 501 (-3.9A)
None
None
 0.82A 6b58A-4kv3A:
undetectable		 6b58A-4kv3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-4kv3A:
undetectable		 6bm5A-4kv3A:
23.28