SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 SER A  56
GLY A 127
ALA A  58
THR A 106
THR A 130
None
FMT  A 501 (-3.4A)
None
None
None
1.30A 1c9sG-4kv7A:
undetectable
1c9sH-4kv7A:
undetectable
1c9sG-4kv7A:
13.40
1c9sH-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 7 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.90A 1c9sT-4kv7A:
undetectable
1c9sU-4kv7A:
undetectable
1c9sT-4kv7A:
13.40
1c9sU-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 11 LEU A  50
LEU A  92
ILE A  95
GLY A  54
LEU A 120
None
1.10A 1g50C-4kv7A:
undetectable
1g50C-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 7 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.88A 1gtfL-4kv7A:
undetectable
1gtfM-4kv7A:
undetectable
1gtfL-4kv7A:
13.40
1gtfM-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.87A 1gtfN-4kv7A:
undetectable
1gtfO-4kv7A:
undetectable
1gtfN-4kv7A:
13.40
1gtfO-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.32A 1gtnL-4kv7A:
undetectable
1gtnM-4kv7A:
undetectable
1gtnL-4kv7A:
13.40
1gtnM-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.33A 1gtnQ-4kv7A:
undetectable
1gtnR-4kv7A:
undetectable
1gtnQ-4kv7A:
13.40
1gtnR-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 ASP A 386
LEU A 380
LEU A 382
None
0.69A 1ikeA-4kv7A:
undetectable
1ikeA-4kv7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 11 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 1utdM-4kv7A:
undetectable
1utdN-4kv7A:
undetectable
1utdM-4kv7A:
13.40
1utdN-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 1utdR-4kv7A:
undetectable
1utdS-4kv7A:
undetectable
1utdR-4kv7A:
13.40
1utdS-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 LEU A 315
LEU A 337
GLY A 343
ALA A  77
ALA A  81
None
1.13A 2bm9C-4kv7A:
4.2
2bm9C-4kv7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 LEU A 315
LEU A 337
GLY A 343
ALA A  77
ALA A  81
None
1.16A 2br4D-4kv7A:
3.4
2br4D-4kv7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 LEU A 315
LEU A 337
GLY A 343
ALA A  77
ALA A  81
None
1.15A 2br4E-4kv7A:
4.7
2br4E-4kv7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 ASN A 232
TYR A 259
SER A 234
None
0.92A 2gvcB-4kv7A:
undetectable
2gvcB-4kv7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 ASN A 232
TYR A 259
SER A 234
None
0.86A 2gvcE-4kv7A:
undetectable
2gvcE-4kv7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 ILE A 192
LEU A 182
GLY A 186
ALA A 252
VAL A 253
None
1.01A 2oc8A-4kv7A:
undetectable
2oc8A-4kv7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 ARG A 231
SER A 200
TYR A 101
None
None
FMT  A 501 (-4.6A)
0.84A 2q2hA-4kv7A:
undetectable
2q2hB-4kv7A:
undetectable
2q2hA-4kv7A:
16.62
2q2hB-4kv7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 TYR A 259
GLU A 260
SER A 234
VAL A 126
None
1.20A 3b9lA-4kv7A:
undetectable
3b9lA-4kv7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 TYR A 229
TYR A 101
GLY A 257
None
FMT  A 501 (-4.6A)
None
0.69A 3eteB-4kv7A:
4.6
3eteD-4kv7A:
5.0
3eteF-4kv7A:
4.6
3eteB-4kv7A:
24.95
3eteD-4kv7A:
24.95
3eteF-4kv7A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 GLY A 343
MET A 323
ILE A 341
VAL A 342
None
1.12A 3kvvD-4kv7A:
2.9
3kvvD-4kv7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 PRO A 103
SER A  56
ASP A  98
PRO A 129
GLY A 127
None
None
None
FMT  A 501 (-4.8A)
FMT  A 501 (-3.4A)
1.44A 3lsfB-4kv7A:
1.9
3lsfE-4kv7A:
4.0
3lsfB-4kv7A:
21.58
3lsfE-4kv7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 PRO A 129
GLY A 127
PRO A 103
SER A  56
ASP A  98
FMT  A 501 (-4.8A)
FMT  A 501 (-3.4A)
None
None
None
1.48A 3lsfB-4kv7A:
2.3
3lsfE-4kv7A:
4.0
3lsfB-4kv7A:
21.58
3lsfE-4kv7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 LEU A 412
ALA A 181
ASP A 180
ILE A 254
LEU A 411
None
1.00A 3ogqA-4kv7A:
undetectable
3ogqA-4kv7A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 GLY A 399
ALA A 302
ALA A 280
LEU A 296
LEU A 289
None
1.04A 3p2kC-4kv7A:
undetectable
3p2kC-4kv7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.48A 3p97C-4kv7A:
undetectable
3p97C-4kv7A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 GLY A 239
ASP A 242
ARG A 228
MET A 178
None
1.10A 3qx3A-4kv7A:
undetectable
3qx3A-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 GLY A 239
ASP A 242
ARG A 228
MET A 178
None
1.06A 3qx3B-4kv7A:
undetectable
3qx3B-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 ASP A 373
ILE A 374
GLY A 375
VAL A 342
ARG A 156
None
1.17A 4acaB-4kv7A:
6.0
4acaC-4kv7A:
6.0
4acaB-4kv7A:
20.72
4acaC-4kv7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 TYR A 229
PHE A 206
GLY A 227
ALA A 269
ILE A 266
None
1.11A 4krhB-4kv7A:
5.0
4krhB-4kv7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 LEU A 265
ALA A 269
GLN A 277
PHE A 278
LEU A 243
None
1.25A 4ltwA-4kv7A:
undetectable
4ltwA-4kv7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 11 THR A 128
GLU A 173
ASP A 203
ASP A 204
GLY A 151
FMT  A 501 (-3.6A)
None
None
None
None
1.32A 4qb9F-4kv7A:
undetectable
4qb9F-4kv7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 7 ALA A 131
SER A 282
GLY A 151
ALA A 152
None
0.80A 4r1zB-4kv7A:
undetectable
4r1zB-4kv7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 TYR A 229
ASN A 232
TYR A 201
PHE A 283
None
None
FMT  A 501 (-3.3A)
FMT  A 501 (-3.1A)
1.23A 4twdB-4kv7A:
undetectable
4twdC-4kv7A:
undetectable
4twdB-4kv7A:
21.68
4twdC-4kv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 TYR A 229
ASN A 232
TYR A 201
PHE A 283
None
None
FMT  A 501 (-3.3A)
FMT  A 501 (-3.1A)
1.27A 4twdC-4kv7A:
undetectable
4twdD-4kv7A:
undetectable
4twdC-4kv7A:
21.68
4twdD-4kv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 TYR A 229
ASN A 232
TYR A 201
PHE A 283
None
None
FMT  A 501 (-3.3A)
FMT  A 501 (-3.1A)
1.20A 4twdD-4kv7A:
undetectable
4twdE-4kv7A:
undetectable
4twdD-4kv7A:
21.68
4twdE-4kv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 TYR A 229
ASN A 232
TYR A 201
PHE A 283
None
None
FMT  A 501 (-3.3A)
FMT  A 501 (-3.1A)
1.23A 4twdG-4kv7A:
undetectable
4twdH-4kv7A:
undetectable
4twdG-4kv7A:
21.68
4twdH-4kv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 TYR A 229
ASN A 232
TYR A 201
PHE A 283
None
None
FMT  A 501 (-3.3A)
FMT  A 501 (-3.1A)
1.25A 4twdI-4kv7A:
undetectable
4twdJ-4kv7A:
undetectable
4twdI-4kv7A:
21.68
4twdJ-4kv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 ALA A 131
PRO A 129
SER A 200
TYR A 171
LEU A 155
None
FMT  A 501 (-4.8A)
None
FMT  A 501 (-4.6A)
None
1.33A 4xqeA-4kv7A:
5.1
4xqeA-4kv7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 ALA A 131
PRO A 129
SER A 200
TYR A 171
LEU A 155
None
FMT  A 501 (-4.8A)
None
FMT  A 501 (-4.6A)
None
1.37A 4xqeB-4kv7A:
4.0
4xqeB-4kv7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 ALA A 131
PRO A 129
SER A 200
TYR A 171
LEU A 155
None
FMT  A 501 (-4.8A)
None
FMT  A 501 (-4.6A)
None
1.36A 4xrgB-4kv7A:
5.2
4xrgB-4kv7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 LEU A 376
GLY A 375
GLU A  80
TYR A 340
LEU A 337
None
1.33A 5czyA-4kv7A:
undetectable
5czyA-4kv7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 4 ILE A 300
ILE A 266
ARG A 270
LEU A 279
None
0.93A 5dzkh-4kv7A:
undetectable
5dzkn-4kv7A:
undetectable
5dzkv-4kv7A:
undetectable
5dzkh-4kv7A:
20.74
5dzkn-4kv7A:
20.74
5dzkv-4kv7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.49A 5e9qC-4kv7A:
2.6
5e9qC-4kv7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.47A 5ec8C-4kv7A:
3.1
5ec8C-4kv7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 SER A  56
GLY A 127
ALA A  58
THR A 106
THR A 130
None
FMT  A 501 (-3.4A)
None
None
None
1.28A 5eeuA-4kv7A:
undetectable
5eeuB-4kv7A:
undetectable
5eeuA-4kv7A:
13.40
5eeuB-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 SER A  56
GLY A 127
ALA A  58
THR A 106
THR A 130
None
FMT  A 501 (-3.4A)
None
None
None
1.28A 5eeuB-4kv7A:
undetectable
5eeuC-4kv7A:
undetectable
5eeuB-4kv7A:
13.40
5eeuC-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 SER A  56
GLY A 127
ALA A  58
THR A 106
THR A 130
None
FMT  A 501 (-3.4A)
None
None
None
1.27A 5eeuH-4kv7A:
undetectable
5eeuI-4kv7A:
undetectable
5eeuH-4kv7A:
13.40
5eeuI-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eeuR-4kv7A:
undetectable
5eeuS-4kv7A:
undetectable
5eeuR-4kv7A:
13.40
5eeuS-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.85A 5eevL-4kv7A:
undetectable
5eevV-4kv7A:
undetectable
5eevL-4kv7A:
13.40
5eevV-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eevR-4kv7A:
undetectable
5eevS-4kv7A:
undetectable
5eevR-4kv7A:
13.40
5eevS-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.85A 5eewL-4kv7A:
undetectable
5eewV-4kv7A:
undetectable
5eewL-4kv7A:
13.40
5eewV-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eewR-4kv7A:
undetectable
5eewS-4kv7A:
undetectable
5eewR-4kv7A:
13.40
5eewS-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eexQ-4kv7A:
undetectable
5eexR-4kv7A:
undetectable
5eexQ-4kv7A:
13.40
5eexR-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 10 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eexR-4kv7A:
undetectable
5eexS-4kv7A:
undetectable
5eexR-4kv7A:
13.40
5eexS-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eeyQ-4kv7A:
undetectable
5eeyR-4kv7A:
undetectable
5eeyQ-4kv7A:
13.40
5eeyR-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.84A 5eezL-4kv7A:
undetectable
5eezV-4kv7A:
undetectable
5eezL-4kv7A:
13.40
5eezV-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5eezQ-4kv7A:
undetectable
5eezR-4kv7A:
undetectable
5eezQ-4kv7A:
13.40
5eezR-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5ef0Q-4kv7A:
undetectable
5ef0R-4kv7A:
undetectable
5ef0Q-4kv7A:
13.40
5ef0R-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.85A 5ef1L-4kv7A:
undetectable
5ef1V-4kv7A:
undetectable
5ef1L-4kv7A:
13.40
5ef1V-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5ef1Q-4kv7A:
undetectable
5ef1R-4kv7A:
undetectable
5ef1Q-4kv7A:
13.40
5ef1R-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.85A 5ef2L-4kv7A:
undetectable
5ef2V-4kv7A:
undetectable
5ef2L-4kv7A:
13.40
5ef2V-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 9 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
FMT  A 501 (-3.4A)
None
None
None
None
1.28A 5ef2Q-4kv7A:
undetectable
5ef2R-4kv7A:
undetectable
5ef2Q-4kv7A:
13.40
5ef2R-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 8 GLY A 127
ALA A  58
THR A 106
THR A 130
FMT  A 501 (-3.4A)
None
None
None
0.85A 5ef3L-4kv7A:
undetectable
5ef3V-4kv7A:
undetectable
5ef3L-4kv7A:
13.40
5ef3V-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
None
1.04A 5ehiC-4kv7A:
undetectable
5ehiC-4kv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.48A 5eifC-4kv7A:
undetectable
5eifC-4kv7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.47A 5kqrA-4kv7A:
2.9
5kqrA-4kv7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.44A 5kqsA-4kv7A:
2.6
5kqsA-4kv7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.46A 5m5bA-4kv7A:
2.9
5m5bA-4kv7A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 GLY A 151
VAL A 281
SER A 170
ALA A 169
VAL A 306
None
0.99A 5n0oB-4kv7A:
2.5
5n0oB-4kv7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
6 / 12 GLY A 209
GLY A 202
THR A 175
ASP A 180
VAL A 179
ILE A 213
None
1.49A 5njvB-4kv7A:
3.1
5njvB-4kv7A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
3 / 3 THR A 114
THR A 141
ARG A 359
None
1.04A 5wm2A-4kv7A:
2.7
5wm2A-4kv7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 4 THR A 114
THR A 141
ALA A 138
ARG A 359
None
1.11A 5wm7A-4kv7A:
undetectable
5wm7A-4kv7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 LEU A  92
LEU A  94
LEU A 346
ALA A 121
ILE A 362
None
0.98A 5xiwB-4kv7A:
undetectable
5xiwB-4kv7A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 TYR A 319
ARG A 320
MET A 323
LEU A 330
None
1.09A 5z86J-4kv7A:
undetectable
5z86J-4kv7A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 GLY A 239
ASP A 242
ARG A 228
MET A 178
None
1.11A 5zrfB-4kv7A:
2.4
5zrfB-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 4 GLY A 239
ASP A 242
ARG A 228
MET A 178
None
1.08A 5zrfA-4kv7A:
1.9
5zrfA-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
5 / 12 ILE A  68
ALA A  58
ALA A 134
ALA A 148
PHE A 145
None
0.89A 5zw4A-4kv7A:
4.7
5zw4A-4kv7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 5 ASP A  99
ILE A 135
PHE A 145
ASN A  69
None
1.24A 6a93B-4kv7A:
undetectable
6a93B-4kv7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica)
4 / 6 ALA A 169
SER A 391
ALA A 172
SER A 170
None
1.03A 6bocA-4kv7A:
undetectable
6bocB-4kv7A:
undetectable
6bocC-4kv7A:
undetectable
6bocD-4kv7A:
undetectable
6bocA-4kv7A:
19.75
6bocB-4kv7A:
19.75
6bocC-4kv7A:
19.75
6bocD-4kv7A:
19.75