SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4kva SEPTIN
(Schistosoma
mansoni) 		5 / 11 ILE A  44
PHE A  40
PHE A  42
THR A 289
VAL A 149
 None
 1.11A 2w3aA-4kvaA:
undetectable		 2w3aA-4kvaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4kva SEPTIN
(Schistosoma
mansoni) 		4 / 8 MET A 169
ALA A 168
THR A 157
PHE A 196
 None
 0.65A 4ltwA-4kvaA:
undetectable		 4ltwA-4kvaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4kva SEPTIN
(Schistosoma
mansoni) 		5 / 12 ILE A 182
LEU A 201
ALA A 198
LEU A 161
ILE A 154
 None
 0.96A 4pssA-4kvaA:
undetectable		 4pssA-4kvaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4kva SEPTIN
(Schistosoma
mansoni) 		4 / 6 ASP A  86
LYS A  40
THR A  84
THR A  97
 None
 1.48A 4w5qA-4kvaA:
2.4		 4w5qA-4kvaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4kva SEPTIN
(Schistosoma
mansoni) 		5 / 9 ILE A 164
ALA A 168
TYR A 104
ILE A 154
LEU A 161
 None
 0.83A 5mvmA-4kvaA:
undetectable
5mvmE-4kvaA:
undetectable		 5mvmA-4kvaA:
11.60
5mvmE-4kvaA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4kva SEPTIN
(Schistosoma
mansoni) 		5 / 10 ILE A 154
LEU A 161
ILE A 164
ALA A 168
TYR A 104
 None
 0.85A 5mvmD-4kvaA:
undetectable
5mvmE-4kvaA:
undetectable		 5mvmD-4kvaA:
11.60
5mvmE-4kvaA:
11.60