SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NYA_A_JTZA1203_1 (BETA-2 ADRENERGIC RECEPTOR, LYSOZYME)	4kvc	IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN (Mus musculus)	5 / 12	VAL H 170 VAL H 188 SER H 186 ASN H 203 ASN H 162	None	1.43A	3nyaA-4kvcH: undetectable	3nyaA-4kvcH: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA501_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4kvc	IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN (Mus musculus)	4 / 5	TYR H 94 LEU H 81 LEU H 86 ARG H 67	None	1.20A	4em2A-4kvcH: undetectable	4em2A-4kvcH: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JWA_A_ACTA609_0 (NADH DEHYDROGENASE, PUTATIVE)	4kvc	IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN (Mus musculus)	3 / 3	VAL H 190 SER H 192 TRP H 195	None	1.04A	5jwaA-4kvcH: undetectable	5jwaA-4kvcH: 17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	4kvc	IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN (Mus musculus)	5 / 5	SER H 119 ALA H 121 PHE H 153 LEU H 177 ASP H 180	None	0.89A	5mthA-4kvcH: 26.3	5mthA-4kvcH: 65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	4kvc	IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN (Mus musculus)	3 / 3	TYR H 60 GLY H 66 THR H 69	None	0.15A	6cjkB-4kvcH: 25.0	6cjkB-4kvcH: 61.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3NYA_A_JTZA1203_1","BETA-2 ADRENERGIC RECEPTOR, LYSOZYME","4kvc","IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN","Mus musculus",5,"VAL H 170;VAL H 188;SER H 186;ASN H 203;ASN H 162","None","1.43A","3nyaA-4kvcH:undetectable","3nyaA-4kvcH:17.41"],["4EM2_A_SALA501_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4kvc","IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN","Mus musculus",4,"TYR H  94;LEU H  81;LEU H  86;ARG H  67","None","1.20A","4em2A-4kvcH:undetectable","4em2A-4kvcH:20.60"],["5JWA_A_ACTA609_0","NADH DEHYDROGENASE, PUTATIVE","4kvc","IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN","Mus musculus",3,"VAL H 190;SER H 192;TRP H 195","None","1.04A","5jwaA-4kvcH:undetectable","5jwaA-4kvcH:17.33"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","4kvc","IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN","Mus musculus",5,"SER H 119;ALA H 121;PHE H 153;LEU H 177;ASP H 180","None","0.89A","5mthA-4kvcH:26.3","5mthA-4kvcH:65.00"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","4kvc","IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN","Mus musculus",3,"TYR H  60;GLY H  66;THR H  69","None","0.15A","6cjkB-4kvcH:25.0","6cjkB-4kvcH:61.26"]]