SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 306
GLY A  82
GLY A  80
ASP A 149
ASN A 301
 None
 1.00A 1xdsA-4kvfA:
2.4		 1xdsA-4kvfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 306
GLY A  82
GLY A  80
ASP A 149
ASN A 301
 None
 1.01A 1xdsB-4kvfA:
2.9		 1xdsB-4kvfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 313
SER A 318
VAL A 122
ALA A 159
ALA A 312
 None
 1.18A 2avdA-4kvfA:
undetectable		 2avdA-4kvfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 10 ASP A 304
GLY A  81
GLY A  82
VAL A 146
ILE A 161
 None
 1.02A 3em4V-4kvfA:
undetectable		 3em4V-4kvfA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		3 / 3 PRO A  56
LEU A  57
GLN A 320
 None
 0.54A 3hznG-4kvfA:
undetectable
3hznH-4kvfA:
undetectable		 3hznG-4kvfA:
23.14
3hznH-4kvfA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 9 VAL A 289
PHE A 361
ILE A 358
ALA A 298
THR A 351
 None
 1.24A 3me6D-4kvfA:
undetectable		 3me6D-4kvfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 ILE A  63
GLY A 343
PHE A 329
LEU A 308
THR A 147
 None
 0.99A 3pwwA-4kvfA:
undetectable		 3pwwA-4kvfA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 5 GLN A 116
TYR A 109
LEU A  61
LYS A  62
 None
 1.41A 3sugA-4kvfA:
undetectable		 3sugA-4kvfA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 5 ARG A 157
LEU A 135
VAL A 145
ASP A 151
 None
 1.15A 3ufnA-4kvfA:
undetectable
3ufnB-4kvfA:
undetectable		 3ufnA-4kvfA:
15.58
3ufnB-4kvfA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 6 THR A 254
GLY A 278
ARG A 263
ILE A 276
 GOL  A 402 (-4.6A)
None
None
None
 1.06A 4acbC-4kvfA:
undetectable		 4acbC-4kvfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 4 LEU A 316
ILE A 345
GLY A 313
PHE A 329
 None
 0.97A 4dc3A-4kvfA:
undetectable		 4dc3A-4kvfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 5 LEU A 299
GLY A 280
ILE A 169
GLN A 163
 None
 1.19A 4ma8C-4kvfA:
undetectable		 4ma8C-4kvfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 LEU A 210
ALA A 177
ILE A 203
GLY A 170
VAL A 189
 None
 1.09A 4nkvA-4kvfA:
undetectable		 4nkvA-4kvfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 LEU A 210
ALA A 177
ILE A 203
GLY A 170
VAL A 189
 None
 1.10A 4nkvC-4kvfA:
undetectable		 4nkvC-4kvfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 12 LEU A 210
ALA A 177
ILE A 203
GLY A 170
VAL A 189
 None
 1.10A 4nkvD-4kvfA:
undetectable		 4nkvD-4kvfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 9 ALA A  51
ALA A  50
VAL A 339
GLY A 326
ALA A 324
 None
 1.10A 4qvnK-4kvfA:
undetectable
4qvnL-4kvfA:
undetectable		 4qvnK-4kvfA:
21.25
4qvnL-4kvfA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		5 / 9 ALA A  51
ALA A  50
VAL A 339
GLY A 326
ALA A 324
 None
 1.10A 4qvnY-4kvfA:
undetectable
4qvnZ-4kvfA:
undetectable		 4qvnY-4kvfA:
21.25
4qvnZ-4kvfA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 5 GLY A 323
THR A 322
GLY A  97
LEU A 135
 None
 0.79A 5jlcA-4kvfA:
undetectable		 5jlcA-4kvfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		3 / 3 GLN A 199
THR A 254
ASP A 228
 GOL  A 402 ( 4.9A)
GOL  A 402 (-4.6A)
GOL  A 402 ( 4.6A)
 0.86A 5k9dA-4kvfA:
undetectable		 5k9dA-4kvfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN
(Kribbella
flavida) 		4 / 7 ASP A 151
GLY A 323
GLY A 343
VAL A 339
 None
 0.83A 6ekzA-4kvfA:
undetectable		 6ekzA-4kvfA:
13.06