SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FML_A_RTLA401_0 (RETINOL DEHYDRATASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 12	TYR B 422 LEU B 337 LEU B 316 LEU B 387 ILE B 342	None	1.28A	1fmlA-4kvgB: undetectable	1fmlA-4kvgB: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK2_A_T44A3003_1 (SERUM ALBUMIN)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	4 / 6	ILE B 371 LYS B 376 LYS B 374 ALA B 379	None	1.13A	1hk2A-4kvgB: undetectable	1hk2A-4kvgB: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_B_FUAB703_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	3 / 3	VAL B 206 ALA B 203 HIS B 240	None	0.75A	1q23C-4kvgB: undetectable	1q23C-4kvgB: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_G_FUAG708_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	3 / 3	VAL B 206 ALA B 203 HIS B 240	None	0.76A	1q23H-4kvgB: undetectable	1q23H-4kvgB: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_I_FUAI707_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	3 / 3	VAL B 206 ALA B 203 HIS B 240	None	0.73A	1q23G-4kvgB: undetectable	1q23G-4kvgB: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_K_FUAK712_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	3 / 3	VAL B 206 ALA B 203 HIS B 240	None	0.79A	1q23L-4kvgB: undetectable	1q23L-4kvgB: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_A_THHA3001_1 (AMINOMETHYLTRANSFERA SE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	3 / 3	ASP B 428 GLU B 299 TYR B 277	EDO B 501 (-2.8A) None None	0.74A	1wsvA-4kvgB: undetectable	1wsvA-4kvgB: 19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_B_BEZB1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 9	LEU B 316 LEU B 336 LEU B 337 ILE B 342 LEU B 320	None	1.08A	2f78B-4kvgB: undetectable	2f78B-4kvgB: 24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F7A_A_BEZA1003_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 9	LEU B 316 LEU B 336 LEU B 337 ILE B 342 LEU B 320	None	1.11A	2f7aA-4kvgB: undetectable	2f7aA-4kvgB: 24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F7A_B_BEZB1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 9	LEU B 316 LEU B 336 LEU B 337 ILE B 342 LEU B 320	None	1.06A	2f7aB-4kvgB: undetectable	2f7aB-4kvgB: 24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A84_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 12	PHE B 306 PRO B 273 PRO B 314 LEU B 316 ALA B 268	None	1.50A	4a84A-4kvgB: undetectable	4a84A-4kvgB: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I1R_A_LZUA801_1 (MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 12	LEU B 210 VAL B 206 PHE B 260 LEU B 259 LEU B 247	None	0.97A	4i1rA-4kvgB: undetectable	4i1rA-4kvgB: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVD_A_SAMA502_0 (D-MYCAROSE 3-C-METHYLTRANSFERAS E)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 12	ILE B 233 GLY B 370 ALA B 379 VAL B 386 ILE B 399	None	0.87A	4rvdA-4kvgB: undetectable	4rvdA-4kvgB: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVG_A_SAMA503_0 (D-MYCAROSE 3-C-METHYLTRANSFERAS E)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	5 / 12	ILE B 233 GLY B 370 ALA B 379 VAL B 386 ILE B 399	None	0.87A	4rvgA-4kvgB: undetectable	4rvgA-4kvgB: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C71_B_NCTB501_1 (AMINE OXIDASE)	4kvg	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN (Mus musculus)	4 / 8	LEU B 426 TYR B 422 GLU B 241 ASN B 366	None	1.06A	6c71B-4kvgB: undetectable	6c71B-4kvgB: 12.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FML_A_RTLA401_0","RETINOL DEHYDRATASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"TYR B 422;LEU B 337;LEU B 316;LEU B 387;ILE B 342","None","1.28A","1fmlA-4kvgB:undetectable","1fmlA-4kvgB:20.45"],["1HK2_A_T44A3003_1","SERUM ALBUMIN","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",4,"ILE B 371;LYS B 376;LYS B 374;ALA B 379","None","1.13A","1hk2A-4kvgB:undetectable","1hk2A-4kvgB:19.15"],["1Q23_B_FUAB703_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",3,"VAL B 206;ALA B 203;HIS B 240","None","0.75A","1q23C-4kvgB:undetectable","1q23C-4kvgB:22.30"],["1Q23_G_FUAG708_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",3,"VAL B 206;ALA B 203;HIS B 240","None","0.76A","1q23H-4kvgB:undetectable","1q23H-4kvgB:22.30"],["1Q23_I_FUAI707_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",3,"VAL B 206;ALA B 203;HIS B 240","None","0.73A","1q23G-4kvgB:undetectable","1q23G-4kvgB:22.30"],["1Q23_K_FUAK712_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",3,"VAL B 206;ALA B 203;HIS B 240","None","0.79A","1q23L-4kvgB:undetectable","1q23L-4kvgB:22.30"],["1WSV_A_THHA3001_1","AMINOMETHYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",3,"ASP B 428;GLU B 299;TYR B 277","EDO B 501 (-2.8A);None;None","0.74A","1wsvA-4kvgB:undetectable","1wsvA-4kvgB:19.06"],["2F78_B_BEZB1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"LEU B 316;LEU B 336;LEU B 337;ILE B 342;LEU B 320","None","1.08A","2f78B-4kvgB:undetectable","2f78B-4kvgB:24.56"],["2F7A_A_BEZA1003_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"LEU B 316;LEU B 336;LEU B 337;ILE B 342;LEU B 320","None","1.11A","2f7aA-4kvgB:undetectable","2f7aA-4kvgB:24.56"],["2F7A_B_BEZB1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"LEU B 316;LEU B 336;LEU B 337;ILE B 342;LEU B 320","None","1.06A","2f7aB-4kvgB:undetectable","2f7aB-4kvgB:24.56"],["4A84_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"PHE B 306;PRO B 273;PRO B 314;LEU B 316;ALA B 268","None","1.50A","4a84A-4kvgB:undetectable","4a84A-4kvgB:21.93"],["4I1R_A_LZUA801_1","MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"LEU B 210;VAL B 206;PHE B 260;LEU B 259;LEU B 247","None","0.97A","4i1rA-4kvgB:undetectable","4i1rA-4kvgB:22.70"],["4RVD_A_SAMA502_0","D-MYCAROSE 3-C-METHYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"ILE B 233;GLY B 370;ALA B 379;VAL B 386;ILE B 399","None","0.87A","4rvdA-4kvgB:undetectable","4rvdA-4kvgB:20.64"],["4RVG_A_SAMA503_0","D-MYCAROSE 3-C-METHYLTRANSFERASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",5,"ILE B 233;GLY B 370;ALA B 379;VAL B 386;ILE B 399","None","0.87A","4rvgA-4kvgB:undetectable","4rvgA-4kvgB:20.64"],["6C71_B_NCTB501_1","AMINE OXIDASE","4kvg","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN","Mus musculus",4,"LEU B 426;TYR B 422;GLU B 241;ASN B 366","None","1.06A","6c71B-4kvgB:undetectable","6c71B-4kvgB:12.69"]]