SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  67
ALA A  48
HIS A  43
 None
 0.64A 1q23C-4kvoA:
undetectable		 1q23C-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  67
ALA A  48
HIS A  43
 None
 0.72A 1q23H-4kvoA:
undetectable		 1q23H-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  67
ALA A  48
HIS A  43
 None
 0.55A 1q23G-4kvoA:
undetectable		 1q23G-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  67
ALA A  48
HIS A  43
 None
 0.67A 1q23L-4kvoA:
undetectable		 1q23L-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  67
ALA A  48
HIS A  43
 None
 0.74A 1q23J-4kvoA:
undetectable		 1q23J-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 115
LEU A 118
ALA A 119
GLN A 122
LEU A 152
 None
 0.78A 1ya3C-4kvoA:
undetectable		 1ya3C-4kvoA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A 134
LEU A 125
GLN A  96
LEU A 121
ARG A  89
 None
 1.41A 3fsuA-4kvoA:
undetectable		 3fsuA-4kvoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 4 SER A 517
ASP A 499
ASP A 462
ALA A 512
 None
 1.33A 3uj6A-4kvoA:
undetectable		 3uj6A-4kvoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A  64
ASP A  91
ARG A  89
HIS A  55
 None
 1.33A 3zodA-4kvoA:
undetectable		 3zodA-4kvoA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 546
PHE A 193
ALA A 153
LEU A 158
 None
 0.75A 4uymA-4kvoA:
0.1		 4uymA-4kvoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 546
PHE A 193
ALA A 153
LEU A 158
 None
 0.71A 4uymB-4kvoA:
undetectable		 4uymB-4kvoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 247
ARG A 228
ARG A 221
 SO4  A 812 (-4.2A)
None
SO4  A 812 (-3.5A)
 0.83A 4yiaB-4kvoA:
undetectable		 4yiaB-4kvoA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 545
ASP A 220
GLU A 226
 None
 0.79A 5fa8A-4kvoA:
undetectable		 5fa8A-4kvoA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A  85
ARG A  68
TRP A  81
ASP A  91
 None
 1.00A 5vlmB-4kvoA:
1.5		 5vlmB-4kvoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 503
ALA A 468
GLY A 482
GLY A 649
ALA A 510
 None
 0.90A 5w4zA-4kvoA:
undetectable		 5w4zA-4kvoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 503
ALA A 468
GLY A 482
GLY A 649
ALA A 510
 None
 0.95A 5w4zB-4kvoA:
undetectable		 5w4zB-4kvoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		4 / 5 THR A 545
ASP A 220
GLU A 226
ASN A 252
 None
 1.02A 5ybbA-4kvoA:
undetectable		 5ybbA-4kvoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 123
TYR A 546
PHE A 538
ALA A 119
LEU A 138
 CL  A 802 (-3.0A)
None
CL  A 802 (-4.5A)
None
None
 1.36A 5zwrB-4kvoA:
undetectable		 5zwrB-4kvoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 417
ASP A 438
LYS A 442
 None
 0.86A 6awtD-4kvoA:
undetectable		 6awtD-4kvoA:
11.66