SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 11 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.27A 1akdA-4kvsA:
0.9		 1akdA-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.16A 1dz4A-4kvsA:
undetectable		 1dz4A-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.14A 1dz4B-4kvsA:
undetectable		 1dz4B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.23A 1dz8A-4kvsA:
undetectable		 1dz8A-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.25A 1dz8B-4kvsA:
undetectable		 1dz8B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.26A 1dz9B-4kvsA:
undetectable		 1dz9B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
LEU A  87
VAL A  89
VAL A  41
ILE A  37
 None
None
None
6NA  A 301 ( 4.2A)
None
 1.17A 1gebA-4kvsA:
undetectable		 1gebA-4kvsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 10 LEU A 223
ALA A 240
ALA A 237
MET A 236
LEU A 180
 None
 1.32A 1rlbE-4kvsA:
undetectable		 1rlbE-4kvsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 5 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.19A 1t88B-4kvsA:
undetectable		 1t88B-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 8 TYR A  30
VAL A  89
GLY A  84
VAL A  41
ILE A  37
 None
None
None
6NA  A 301 ( 4.2A)
None
 1.26A 2a1mB-4kvsA:
undetectable		 2a1mB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 11 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.20A 2a1nA-4kvsA:
undetectable		 2a1nA-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.19A 2a1oB-4kvsA:
undetectable		 2a1oB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 TYR A  30
VAL A  89
GLY A  84
VAL A  41
ILE A  37
 None
None
None
6NA  A 301 ( 4.2A)
None
 1.21A 2a1oB-4kvsA:
undetectable		 2a1oB-4kvsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 10 TYR A  30
LEU A  87
VAL A  89
GLY A  84
VAL A  41
 None
None
None
None
6NA  A 301 ( 4.2A)
 1.19A 2cp4A-4kvsA:
undetectable		 2cp4A-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 5 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.18A 2m56A-4kvsA:
undetectable		 2m56A-4kvsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 9 LEU A 126
LEU A 121
MET A 236
ALA A 237
MET A 193
 None
 1.38A 3cldA-4kvsA:
undetectable		 3cldA-4kvsA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 10 TYR A  34
ILE A  40
LYS A  85
GLY A  84
LEU A 204
 None
 1.32A 3em0A-4kvsA:
undetectable		 3em0A-4kvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.13A 3fwgA-4kvsA:
undetectable		 3fwgA-4kvsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		5 / 12 TYR A  30
LEU A 204
VAL A  41
ALA A 146
PHE A  80
 None
None
6NA  A 301 ( 4.2A)
None
None
 1.29A 3nhxA-4kvsA:
undetectable		 3nhxA-4kvsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 5 ALA A 131
GLU A  73
GLU A  45
ALA A  48
 6NA  A 301 (-3.5A)
FE  A 303 (-2.4A)
FE  A 302 ( 2.4A)
6NA  A 301 (-3.5A)
 1.24A 3r9tC-4kvsA:
undetectable		 3r9tC-4kvsA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.13A 3wrjE-4kvsA:
undetectable		 3wrjE-4kvsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 GLU A  45
TYR A 135
HIS A 136
VAL A 141
 FE  A 302 ( 2.4A)
6NA  A 301 ( 4.9A)
None
None
 0.84A 4a97E-4kvsA:
2.5		 4a97E-4kvsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 4 ASN A  38
ALA A  91
GLY A  84
THR A  81
 None
 1.17A 4bboC-4kvsA:
undetectable		 4bboC-4kvsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.15A 4g3rB-4kvsA:
undetectable		 4g3rB-4kvsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 7 GLU A  43
ASP A  50
GLN A  46
ILE A 127
 None
None
None
6NA  A 301 (-4.8A)
 1.26A 4ii8A-4kvsA:
undetectable		 4ii8A-4kvsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 6 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.16A 4kkyX-4kvsA:
undetectable		 4kkyX-4kvsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 5 TYR A  30
LEU A  87
VAL A  89
VAL A  41
 None
None
None
6NA  A 301 ( 4.2A)
 1.14A 4l49A-4kvsA:
undetectable		 4l49A-4kvsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kvs ALDEHYDE
DECARBONYLASE
(Prochlorococcus
marinus) 		4 / 8 ILE A 127
GLU A 128
GLN A 123
ILE A  55
 6NA  A 301 (-4.8A)
FE  A 303 ( 1.9A)
6NA  A 301 (-4.0A)
None
 0.92A 4mj8A-4kvsA:
undetectable		 4mj8A-4kvsA:
20.99