SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 PHE A 115
LYS A 121
ALA A 119
MET A 148
 None
 1.25A 1hk2A-4kw2A:
undetectable		 1hk2A-4kw2A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 LEU A 227
LEU A 266
SER A 262
GLU A 218
 None
 1.07A 1i7zA-4kw2A:
undetectable		 1i7zA-4kw2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 PHE A 101
LEU A  75
MET A  43
 None
 0.82A 1mx1D-4kw2A:
undetectable		 1mx1D-4kw2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 THR A  73
ALA A  59
PHE A 118
LEU A  46
 None
 1.14A 2hzqA-4kw2A:
undetectable		 2hzqA-4kw2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 ILE A  32
GLY A  31
LEU A 244
PHE A  91
 None
 0.90A 2vctB-4kw2A:
undetectable		 2vctB-4kw2A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 GLU A  58
HIS A 209
THR A 128
 None
 0.78A 3hkuA-4kw2A:
undetectable		 3hkuA-4kw2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 5 ASN A 197
ASP A 183
GLU A  58
THR A 128
 None
 1.38A 3p2kC-4kw2A:
undetectable		 3p2kC-4kw2A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 VAL A 233
GLN A 267
CYH A 269
 None
EDO  A 307 ( 4.9A)
None
 0.82A 5icxA-4kw2A:
undetectable
5icxE-4kw2A:
undetectable		 5icxA-4kw2A:
22.30
5icxE-4kw2A:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 11 VAL A 207
VAL A 127
THR A 128
ILE A  99
ALA A 124
 None
 1.17A 6h1lB-4kw2A:
undetectable		 6h1lB-4kw2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4kw2 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 HIS A 186
ASP A 215
THR A 214
LEU A 263
 None
 1.21A 6nmfA-4kw2A:
undetectable
6nmfC-4kw2A:
undetectable
6nmfP-4kw2A:
undetectable		 6nmfA-4kw2A:
20.04
6nmfC-4kw2A:
21.97
6nmfP-4kw2A:
21.97