SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4kw3 NS1
(Human
bocavirus) 		4 / 5 LEU A  33
GLU A 159
ALA A  36
LEU A  34
 None
 1.13A 1eta1-4kw3A:
undetectable		 1eta1-4kw3A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4kw3 NS1
(Human
bocavirus) 		4 / 5 LEU A  33
GLU A 159
ALA A  36
LEU A  34
 None
 1.14A 1eta2-4kw3A:
undetectable		 1eta2-4kw3A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4kw3 NS1
(Human
bocavirus) 		4 / 6 LEU A  33
GLU A 159
ALA A  36
LEU A  34
 None
 1.15A 1etb1-4kw3A:
undetectable		 1etb1-4kw3A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4kw3 NS1
(Human
bocavirus) 		4 / 5 LEU A  89
VAL A 120
TYR A  18
THR A  86
 None
 1.49A 1nw3A-4kw3A:
undetectable		 1nw3A-4kw3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4kw3 NS1
(Human
bocavirus) 		3 / 3 LEU A  89
HIS A  92
LYS A  93
 None
 0.79A 1y7iA-4kw3A:
undetectable		 1y7iA-4kw3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4kw3 NS1
(Human
bocavirus) 		5 / 11 ASN A 248
GLY A 121
THR A  86
ILE A 118
THR A  17
 None
 1.43A 2f9wA-4kw3A:
undetectable
2f9wB-4kw3A:
undetectable		 2f9wA-4kw3A:
19.74
2f9wB-4kw3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4kw3 NS1
(Human
bocavirus) 		3 / 3 ARG A 217
SER A 230
TYR A 242
 None
 1.02A 2q2hA-4kw3A:
undetectable
2q2hB-4kw3A:
undetectable		 2q2hA-4kw3A:
18.45
2q2hB-4kw3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4kw3 NS1
(Human
bocavirus) 		3 / 3 ARG A 217
ARG A 257
ILE A 219
 None
 0.89A 4b7qA-4kw3A:
undetectable		 4b7qA-4kw3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4kw3 NS1
(Human
bocavirus) 		5 / 12 PHE A 207
PRO A 204
ASN A 248
LEU A 246
TYR A  83
 None
 1.46A 4oadA-4kw3A:
undetectable		 4oadA-4kw3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4kw3 NS1
(Human
bocavirus) 		5 / 12 PHE A  22
GLY A 110
ILE A 141
PRO A  23
LEU A 169
 None
 0.96A 5e72A-4kw3A:
undetectable		 5e72A-4kw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4kw3 NS1
(Human
bocavirus) 		5 / 12 HIS A  73
GLY A  75
ASP A  71
HIS A 244
LEU A 246
 None
 1.44A 5eeiA-4kw3A:
undetectable		 5eeiA-4kw3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kw3 NS1
(Human
bocavirus) 		3 / 3 LEU A 125
TYR A  18
SER A 133
 None
 0.89A 5iktA-4kw3A:
undetectable		 5iktA-4kw3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4kw3 NS1
(Human
bocavirus) 		3 / 3 ARG A 148
LYS A  80
ARG A 257
 None
 1.33A 6c06D-4kw3A:
undetectable		 6c06D-4kw3A:
undetectable