SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		5 / 11 VAL A  26
LEU A  71
THR A  15
HIS A  81
TYR A  41
 None
 1.21A 1mmtA-4kw6A:
undetectable		 1mmtA-4kw6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.81A 1p7lC-4kw6A:
undetectable		 1p7lC-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.83A 1p7lD-4kw6A:
undetectable		 1p7lD-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.81A 1rg9A-4kw6A:
undetectable		 1rg9A-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.82A 1rg9B-4kw6A:
undetectable		 1rg9B-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.81A 1rg9C-4kw6A:
undetectable		 1rg9C-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.82A 1rg9D-4kw6A:
undetectable		 1rg9D-4kw6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 7 ILE A 130
TYR A  35
PHE A 160
ASP A 164
 None
 1.11A 2qebA-4kw6A:
undetectable		 2qebA-4kw6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 7 ILE A 130
TYR A  35
PHE A 160
ASP A 164
 None
 1.06A 2qebB-4kw6A:
undetectable		 2qebB-4kw6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 6 ASP A 104
PHE A  40
ASP A 112
TYR A 113
 None
 1.25A 2todA-4kw6A:
undetectable
2todB-4kw6A:
undetectable		 2todA-4kw6A:
18.70
2todB-4kw6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		5 / 9 THR A 140
ILE A 139
PHE A 160
ARG A 137
ILE A 129
 None
 1.47A 2y7wA-4kw6A:
undetectable		 2y7wA-4kw6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 4 LEU A  66
ASP A 131
VAL A  37
THR A 153
 None
 1.20A 3cyxB-4kw6A:
undetectable		 3cyxB-4kw6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		5 / 12 TYR A  41
PHE A  45
SER A  80
VAL A  18
PHE A  23
 None
 1.35A 3nbrA-4kw6A:
undetectable		 3nbrA-4kw6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		5 / 12 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
 None
 1.02A 5l0zA-4kw6A:
3.2		 5l0zA-4kw6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		5 / 10 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
 None
 1.00A 5l0zB-4kw6A:
3.1		 5l0zB-4kw6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4kw6 PEROXIREDOXIN-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.93A 5t8sB-4kw6A:
undetectable		 5t8sB-4kw6A:
20.00